1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog

Forodesine (Synonyms: BCX-1777 freebase; Immucillin-H)

Cat. No.: HY-16210
Handling Instructions

Forodesine(BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells.

For research use only. We do not sell to patients.

Forodesine Chemical Structure

Forodesine Chemical Structure

CAS No. : 209799-67-7

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2500 μg USD 420 Get quote
5 mg USD 600 Get quote
10 mg USD 1080 Get quote

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Description

Forodesine(BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells. IC50 value: Target: PNP inhibitor Forodesine and ara-G cytotoxicities were higher in T-cell acute lymphoblastic leukemia (T-ALL) samples than in B-cell precursor (BCP)-ALL and acute myeloid leukemia (AML) samples. Resistance to forodesine did not preclude ara-G sensitivity and vice versa, indicating that both drugs rely on different resistance mechanisms [1]. BCX1777 was well tolerated at doses up to 300 mg once daily and showed preliminary evidence of activity in relapsed or refractory peripheral T/natural killer-cell malignancies, warranting further investigation [2]. after 48 hours of treatment with forodesine there was a slight dGTP increase in 5T33MM and RPMI-8226 MM cells associated with partial inhibition of proliferation and a limited induction of apoptosis [3]. In the presence of 10 μM deoxyguanosine, forodesine effectively inhibited the growth of CEM cells but not that of CEM/ara-G cells [4].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7559 mL 18.7793 mL 37.5587 mL
5 mM 0.7512 mL 3.7559 mL 7.5117 mL
10 mM 0.3756 mL 1.8779 mL 3.7559 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

266.25

Formula

C₁₁H₁₄N₄O₄

CAS No.

209799-67-7

SMILES

O=C1C(NC=C2[[email protected]@H]3N[[email protected]](CO)[[email protected]@H](O)[[email protected]]3O)=C2NC=N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Forodesine
Cat. No.:
HY-16210
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Forodesine

Cat. No.: HY-16210