1. Cell Cycle/DNA Damage
    Apoptosis
  2. Nucleoside Antimetabolite/Analog
    Apoptosis
  3. Forodesine hydrochloride

Forodesine hydrochloride (Synonyms: BCX-1777; Immucillin-H hydrochloride)

Cat. No.: HY-16209 Purity: 99.86%
Handling Instructions

Forodesine hydrochloride (BCX-1777) is a highly potent and specific purine nucleoside phosphorylase (PNP) inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells of chronic lymphocytic leukemia patients by increasing the dGTP levels.

For research use only. We do not sell to patients.

Forodesine hydrochloride Chemical Structure

Forodesine hydrochloride Chemical Structure

CAS No. : 284490-13-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 400 In-stock
Estimated Time of Arrival: December 31
1 mg USD 216 In-stock
Estimated Time of Arrival: December 31
5 mg USD 600 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Forodesine hydrochloride:

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Description

Forodesine hydrochloride (BCX-1777) is a highly potent and specific purine nucleoside phosphorylase (PNP) inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells of chronic lymphocytic leukemia patients by increasing the dGTP levels[1].

IC50 & Target

PNP[1]

In Vitro

Forodesine (10-30 μM; 24 and 48 hours; RPMI-8226, MOLT-4 and 5T33MM cells) treatment is partially inhibition of proliferation[1].
Forodesine (10-30 μM; 24 and 48 hours; RPMI-8226, MOLT-4 and 5T33MM cells) has no effect on the MM cells at 24 hours, while it could reduce the percentage of living cells in the MOLT-4 cells with 40%[1].

Cell Proliferation Assay[1]

Cell Line: Human RPMI-8226, human MOLT-4 (T-ALL) cells, 5T33MM (Multiple myeloma, MM).
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 and 48 hours
Result: At the effects at 48 hours, a complete block in proliferation in the MOLT-4 cells and 15% reduction in the 5T33MM cells.

Apoptosis Analysis[1]

Cell Line: Human RPMI-8226, human MOLT-4 (T-ALL) cells, 5T33MM (Multiple myeloma, MM).
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 and 48 hours
Result: A limited induction of apoptosis.
Clinical Trial
Molecular Weight

302.71

Formula

C₁₁H₁₅ClN₄O₄

CAS No.

284490-13-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (55.07 mM; Need ultrasonic)

DMSO : 16.67 mg/mL (55.07 mM; Need ultrasonic)

DMF : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3035 mL 16.5175 mL 33.0349 mL
5 mM 0.6607 mL 3.3035 mL 6.6070 mL
10 mM 0.3303 mL 1.6517 mL 3.3035 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ForodesineBCX-1777Immucillin-HBCX1777BCX 1777Nucleoside Antimetabolite/AnalogApoptosisInhibitorinhibitorinhibit

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Forodesine hydrochloride
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HY-16209
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