1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog

Forodesine hydrochloride (Synonyms: BCX-1777; Immucillin-H hydrochloride)

Cat. No.: HY-16209 Purity: 99.77%
Data Sheet SDS Handling Instructions

Forodesine Hcl (BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells.

For research use only. We do not sell to patients.
Forodesine hydrochloride Chemical Structure

Forodesine hydrochloride Chemical Structure

CAS No. : 284490-13-7

Size Price Stock Quantity
10 mM * 1 mL in Water $333 In-stock
1000 ug $180 In-stock
2500 ug $350 In-stock
5 mg $500 In-stock
10 mg $900 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of Forodesine hydrochloride:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Forodesine Hcl (BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells. IC50 value: Target: PNP inhibitor Forodesine and ara-G cytotoxicities were higher in T-cell acute lymphoblastic leukemia (T-ALL) samples than in B-cell precursor (BCP)-ALL and acute myeloid leukemia (AML) samples. Resistance to forodesine did not preclude ara-G sensitivity and vice versa, indicating that both drugs rely on different resistance mechanisms [1]. BCX1777 was well tolerated at doses up to 300 mg once daily and showed preliminary evidence of activity in relapsed or refractory peripheral T/natural killer-cell malignancies, warranting further investigation [2]. after 48 hours of treatment with forodesine there was a slight dGTP increase in 5T33MM and RPMI-8226 MM cells associated with partial inhibition of proliferation and a limited induction of apoptosis [3]. In the presence of 10 μM deoxyguanosine, forodesine effectively inhibited the growth of CEM cells but not that of CEM/ara-G cells [4].

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References
Molecular Weight

302.71

Formula

C₁₁H₁₅ClN₄O₄

CAS No.

284490-13-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 74.1 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.77%

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Product Name:
Forodesine hydrochloride
Cat. No.:
HY-16209
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