1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. Forodesine hydrochloride

Forodesine hydrochloride (Synonyms: BCX-1777; Immucillin-H hydrochloride)

Cat. No.: HY-16209 Purity: 99.86%
Handling Instructions

Forodesine hydrochloride (BCX-1777) is a highly potent and specific purine nucleoside phosphorylase (PNP) inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells of chronic lymphocytic leukemia patients by increasing the dGTP levels.

For research use only. We do not sell to patients.

Forodesine hydrochloride Chemical Structure

Forodesine hydrochloride Chemical Structure

CAS No. : 284490-13-7

Size Price Stock Quantity
10 mM * 1 mL in Water USD 400 In-stock
Estimated Time of Arrival: December 31
1000 μg USD 216 In-stock
Estimated Time of Arrival: December 31
2500 μg USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 600 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Forodesine hydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE Forodesine hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Forodesine hydrochloride (BCX-1777) is a highly potent and specific purine nucleoside phosphorylase (PNP) inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells of chronic lymphocytic leukemia patients by increasing the dGTP levels[1].

In Vitro

Forodesine (10-30 μM; 24 and 48 hours; Human RPMI-8226 (Multiple myeloma, MM), and human MOLT-4 (T-ALL) cells) treatment is partially inhibition of proliferation[1].
Forodesine (10-30 μM; 24 and 48 hours; Human RPMI-8226 (MM), and human MOLT-4 (T-ALL) cells) treatment is a limit induction of apoptosis[1].

Cell Viability Assay[1]

Cell Line: Human RPMI-8226 (MM), and human MOLT-4 (T-ALL) cells.
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 and 48 hours
Result: Partially inhibited cell proliferation.

Apoptosis Analysis[1]

Cell Line: Human RPMI-8226 (MM), and human MOLT-4 (T-ALL) cells.
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 and 48 hours
Result: A limited induction of apoptosis.
Clinical Trial
Molecular Weight

302.71

Formula

C₁₁H₁₅ClN₄O₄

CAS No.

284490-13-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 74.1 mg/mL (244.79 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3035 mL 16.5175 mL 33.0349 mL
5 mM 0.6607 mL 3.3035 mL 6.6070 mL
10 mM 0.3303 mL 1.6517 mL 3.3035 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.86%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Forodesine hydrochloride
Cat. No.:
HY-16209
Quantity: