1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog

Forodesine hydrochloride (Synonyms: BCX-1777; Immucillin-H hydrochloride)

Cat. No.: HY-16209 Purity: 99.86%
Handling Instructions

Forodesine Hcl (BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells.

For research use only. We do not sell to patients.

Forodesine hydrochloride Chemical Structure

Forodesine hydrochloride Chemical Structure

CAS No. : 284490-13-7

Size Price Stock Quantity
10 mM * 1 mL in Water USD 400 In-stock
Estimated Time of Arrival: December 31
1000 μg USD 216 In-stock
Estimated Time of Arrival: December 31
2500 μg USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 600 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of Forodesine hydrochloride:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Forodesine Hcl (BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells. IC50 value: Target: PNP inhibitor Forodesine and ara-G cytotoxicities were higher in T-cell acute lymphoblastic leukemia (T-ALL) samples than in B-cell precursor (BCP)-ALL and acute myeloid leukemia (AML) samples. Resistance to forodesine did not preclude ara-G sensitivity and vice versa, indicating that both drugs rely on different resistance mechanisms [1]. BCX1777 was well tolerated at doses up to 300 mg once daily and showed preliminary evidence of activity in relapsed or refractory peripheral T/natural killer-cell malignancies, warranting further investigation [2]. after 48 hours of treatment with forodesine there was a slight dGTP increase in 5T33MM and RPMI-8226 MM cells associated with partial inhibition of proliferation and a limited induction of apoptosis [3]. In the presence of 10 μM deoxyguanosine, forodesine effectively inhibited the growth of CEM cells but not that of CEM/ara-G cells [4].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : ≥ 74.1 mg/mL (244.79 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3035 mL 16.5175 mL 33.0349 mL
5 mM 0.6607 mL 3.3035 mL 6.6070 mL
10 mM 0.3303 mL 1.6517 mL 3.3035 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

302.71

Formula

C₁₁H₁₅ClN₄O₄

CAS No.

284490-13-7

SMILES

O=C1C(NC=C2[[email protected]@H]3N[[email protected]](CO)[[email protected]@H](O)[[email protected]]3O)=C2NC=N1.Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.86%

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Product Name:
Forodesine hydrochloride
Cat. No.:
HY-16209
Quantity:

Forodesine hydrochloride

Cat. No.: HY-16209