D-タガトース
Based on 1 Customer Validation
D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 87-81-0
- 分子式: C6H12O6
- 分子量:180.16
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
D-Tagatose was synthesized from starch via an ATP-free in vitro multi-enzyme pathway, with high yield enabled by the final irreversible dephosphorylation step[1].
D-Tagatose does not increase mutation frequency in mouse L5178Y lymphoma cancer cells, with or without metabolic activation[2].
D-Tagatose is thermally stable in milk and lemonade, with minimal degradation and preserved prebiotic activity during processing and storage[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
D-Tagatose (sole carbohydrate source in diet; dietary; ad libitum; 16 weeks), when substituted for sucrose in hypercholesterolemic mouse diets, prevents the development of obesity, hyperglycemia, hyperlipidemia, and atherosclerosis observed with sucrose feeding[2].
D-Tagatose produces antidiabetic effects in the SHR/N-cp rat model of type 2 diabetes[2].
D-Tagatose (0.9-1.8 g/(rat·d); oral; mixed with basal diet; 21-day adaptation period; 40-41-day balance period) provides effectively zero net metabolizable energy to growing male Wistar rats, with a calculated NEVs of -0.5 kJ/g that is not significantly different from zero[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, initial weight 80-100 g)[3]
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Dosage:0.9 g/(rat·d); 1.8 g/(rat·d)
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Administration:oral (mixed with basal diet; 21-day adaptation period; 40- or 41-day balance period)
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Result:Did not significantly alter live weight gain during the balance period.
Did not increase energy gain as protein or fat, unlike sucrose.
Yielded a calculated net metabolizable energy value (NEVs) of -0.5 kJ/g (SEM ±2.2 kJ/g), which was not significantly different from zero.
Elevated metabolizable energy for maintenance plus substrate-induced energy losses by 24 kJ/g average protein mass after adjustment for balance period duration and lean mass.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 87-81-0
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性状 Solid
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分子量 180.16
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分子式 C6H12O6
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Color White to off-white
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SMILES
OCC([C@@H](O)[C@@H](O)[C@H](O)CO)=O
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別名
D-Tagatose; D-(-)-Tagatose
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (555.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Fan L, et al. Biosynthesis of a healthy natural sugar D-tagatose: advances and opportunities. Crit Rev Biotechnol. 2025;45(7):1492-1507. [Content Brief]
[2]. Guerrero-Wyss M, et al. D-Tagatose Is a Promising Sweetener to Control Glycaemia: A New Functional Food. Biomed Res Int. 2018;2018:8718053. Published 2018 Jan 9. [Content Brief]
[3]. Livesey G, et al. D-tagatose is a bulk sweetener with zero energy determined in rats. J Nutr. 1996 Jun;126(6):1601-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.5506 mL | 27.7531 mL | 55.5062 mL | 138.7655 mL |
| 5 mM | 1.1101 mL | 5.5506 mL | 11.1012 mL | 27.7531 mL | |
| 10 mM | 0.5551 mL | 2.7753 mL | 5.5506 mL | 13.8766 mL | |
| 15 mM | 0.3700 mL | 1.8502 mL | 3.7004 mL | 9.2510 mL | |
| 20 mM | 0.2775 mL | 1.3877 mL | 2.7753 mL | 6.9383 mL | |
| 25 mM | 0.2220 mL | 1.1101 mL | 2.2202 mL | 5.5506 mL | |
| 30 mM | 0.1850 mL | 0.9251 mL | 1.8502 mL | 4.6255 mL | |
| 40 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4691 mL | |
| 50 mM | 0.1110 mL | 0.5551 mL | 1.1101 mL | 2.7753 mL | |
| 60 mM | 0.0925 mL | 0.4626 mL | 0.9251 mL | 2.3128 mL | |
| 80 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7346 mL | |
| 100 mM | 0.0555 mL | 0.2775 mL | 0.5551 mL | 1.3877 mL |
D-Tagatose 関連分類
HY-42680 関連分類
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