2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. D-Tagatose

D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.

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D-Tagatose

D-Tagatose Chemical Structure

CAS No. : 87-81-0

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Based on 1 publication(s) in Google Scholar

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D-Tagatose Related Antibodies

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Description

D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

D-Tagatose was synthesized from starch via an ATP-free in vitro multi-enzyme pathway, with high yield enabled by the final irreversible dephosphorylation step[1].
D-Tagatose does not increase mutation frequency in mouse L5178Y lymphoma cancer cells, with or without metabolic activation[2].
D-Tagatose is thermally stable in milk and lemonade, with minimal degradation and preserved prebiotic activity during processing and storage[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Tagatose Related Antibodies
In Vivo

D-Tagatose (4000-20000 mg/kg/day; i.g.; daily; gestational days 6 to 15) shows no developmental toxicity in Sprague-Dawley rats at doses up to 20000 mg/kg/day, with only transient gastrointestinal effects and reduced food intake at mid and high doses[2].
D-Tagatose (sole carbohydrate source in diet; dietary; ad libitum; 16 weeks), when substituted for sucrose in hypercholesterolemic mouse diets, prevents the development of obesity, hyperglycemia, hyperlipidemia, and atherosclerosis observed with sucrose feeding[2].
D-Tagatose produces antidiabetic effects in the SHR/N-cp rat model of type 2 diabetes[2].
D-Tagatose (0.9-1.8 g/(rat·d); oral; mixed with basal diet; 21-day adaptation period; 40-41-day balance period) provides effectively zero net metabolizable energy to growing male Wistar rats, with a calculated NEVs of -0.5 kJ/g that is not significantly different from zero[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, initial weight 80-100 g)[3]
Dosage: 0.9 g/(rat·d); 1.8 g/(rat·d)
Administration: oral (mixed with basal diet; 21-day adaptation period; 40- or 41-day balance period)
Result: Did not significantly alter live weight gain during the balance period.
Did not increase energy gain as protein or fat, unlike sucrose.
Yielded a calculated net metabolizable energy value (NEVs) of -0.5 kJ/g (SEM ±2.2 kJ/g), which was not significantly different from zero.
Elevated metabolizable energy for maintenance plus substrate-induced energy losses by 24 kJ/g average protein mass after adjustment for balance period duration and lean mass.
Clinical Trial
Molecular Weight

180.16

Formula

C6H12O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC([C@@H](O)[C@@H](O)[C@H](O)CO)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (555.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5506 mL 27.7531 mL 55.5062 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

SDS (396 KB)

COA (245 KB) HNMR (231 KB) RP-HPLC (273 KB) MS (79 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.5506 mL 27.7531 mL 55.5062 mL 138.7655 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL 27.7531 mL
10 mM 0.5551 mL 2.7753 mL 5.5506 mL 13.8766 mL
15 mM 0.3700 mL 1.8502 mL 3.7004 mL 9.2510 mL
20 mM 0.2775 mL 1.3877 mL 2.7753 mL 6.9383 mL
25 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
30 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6255 mL
40 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4691 mL
50 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
60 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
80 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL
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D-Tagatose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Tagatose87-81-0D-(-)-TagatoseEndogenous Metabolitetype 2 diabetesChinese hamster ovary cellshyperlipidemiaglucokinasediabetessucraseGLP-1glycogen phosphorylaseintestinal disaccharidasemaltaseInhibitorinhibitorinhibit

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