2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. BCX-5

BCX-5 (PD 141955) is an orally active inhibitor of purine nucleoside phosphorylase (PNP) with a Ki of 0.08 μM. BCX-5 can inhibit cell proliferation and mixed lymphocyte reaction. BCX-5 can increase plasma inosine and guanosine levels. BCX-5 can be used for the research of immunology.

For research use only. We do not sell to patients.

BCX-5

BCX-5 Chemical Structure

CAS No. : 132138-76-2

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BCX-5 Related Antibodies

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Description

BCX-5 (PD 141955) is an orally active inhibitor of purine nucleoside phosphorylase (PNP) with a Ki of 0.08 μM. BCX-5 can inhibit cell proliferation and mixed lymphocyte reaction. BCX-5 can increase plasma inosine and guanosine levels. BCX-5 can be used for the research of immunology[1][2].

In Vivo

BCX-5 (150 mg/kg, p.o.) produces a elevation of plasma inosine and guanosine in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

246.29

Formula

C11H10N4OS
CAS No.
SMILES

O=C(NC(N)=N1)C2=C1C(CC3=CSC=C3)=CN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BCX-5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCX-5132138-76-2PD 141955BCX5BCX 5PD141955PD-141955Nucleoside Antimetabolite/Analogpurine nucleoside phosphorylasePNPmixed lymphocyte reactioninosineguanosineInhibitorinhibitorinhibit

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