132138-76-2
132138-76-2
Chemical Structure
BCX-5
Synonym(s): PD 141955
- No. CAS: 132138-76-2
- Formula:C11H10N4OS
- Molecular Weight:246.29
IUPAC Name: 2-amino-7-(thiophen-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
InChIKey: QDPMHXUWMPNTEQ-UHFFFAOYSA-N
SMILES: O=C(NC(N)=N1)C2=C1C(CC3=CSC=C3)=CN2
Biological Activity: BCX-5 (PD 141955) is an orally active inhibitor of purine nucleoside phosphorylase (PNP) with a Ki of 0.08 μM. BCX-5 can inhibit cell proliferation and mixed lymphocyte reaction. BCX-5 can increase plasma inosine and guanosine levels. BCX-5 can be used for the research of immunology[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BCX-5 | BCX-5 (PD 141955) is an orally active inhibitor of purine nucleoside phosphorylase (PNP) with a Ki of 0.08 μM. BCX-5 can inhibit cell proliferation and mixed lymphocyte reaction. BCX-5 can increase plasma inosine and guanosine levels. BCX-5 can be used for the research of immunology. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Gilbertsen RB, et al. Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955. Biochem Pharmacol. 1992 Sep 1;44(5):996-9. [Content Brief]
- [2]. Wilburn DJ, et al. PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR). Agents Actions. 1993;39 Spec No:C96-8. [Content Brief]
Keywords
