2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
  4. Tubercidin

Tubercidin  (Synonyms: 7-Deazaadenosine)

Cat. No.: HY-100126 Purity: ≥98.0%
COA Handling Instructions

Tuberculine (7-déazadénosine) est un antibiotique obtenu à partir de Streptomyces tubercidicus. Tuberculine inhibe la croissance de Streptococcus faecalis (8043) avec un IC50 de 0,02 μM. Tuberculine inhibe les polymérases en incorporant l'ADN ou l'ARN, inhibant ainsi la réplication de l'ADN, la synthèse d'ARN et de protéines.Tuberculine est un inhibiteur faible de l'adénosine phosphorylase et interfère avec la phosphorylation de l'adénosine et de l'AMP.

Tubercidin (7-Deazaadenosin) ist ein Antibiotikum, das aus Streptomyces tubercidicus gewonnen wird. Tubercidin hemmt das Wachstum von Streptococcus faecalis 8043 mit einem IC50 von 0,02 μM. Tubercidin hemmt Polymerasen durch Einbau von DNA oder RNA, wodurch die DNA-Replikation, RNA- und Proteinsynthese gehemmt wird. Tubercidin ist ein schwacher Inhibitor der Adenosinphosphorylase und stört die Phosphorylierung von Adenosin und AMP.

Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP. Tubercidin has antiviral activity.

For research use only. We do not sell to patients.

Tubercidin Chemical Structure

Tubercidin Chemical Structure

CAS No. : 69-33-0

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Based on 2 publication(s) in Google Scholar

Tubercidin Related Antibodies

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Description

Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2].

In Vitro

Tubercidin (7-Deazaadenosine) (0-10 nM; 14 days) has a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells, and the IC50s of tubercidin are 3.4 nM and 3.7 nM for CFU-GM and BFU-E, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubercidin Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: Human bone marrow progenitor cells
Concentration: 0-10 nM
Incubation Time: 14 days
Result: Had a dose-dependent inhibitory effect for CFU-GM and BFU-E.
In Vivo

Tubercidin (7-Deazaadenosine) (intraperitoneal injection; 5 mg/kg; 10 days) in cooperation with NBMPR-P protects the mice from the lethality of tubercidin and allowed the repetition of the regimen for a second time with 100% survival[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD1 mice[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg; 10 days
Result: Protected the mice from the lethality of tubercidin.
Molecular Weight

266.25

Appearance

Solid

Formula

C11H14N4O4
CAS No.
SMILES

O[C@H]1[C@@H](O)[C@H](N2C=CC3=C2N=CN=C3N)O[C@@H]1CO
Structure Classification
Initial Source

Streptomyces tubercidicus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (112.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7559 mL 18.7793 mL 37.5587 mL
5 mM 0.7512 mL 3.7559 mL 7.5117 mL
10 mM 0.3756 mL 1.8779 mL 3.7559 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.68%

COA (255 KB) HNMR (181 KB) LCMS (399 KB)

Handling Instructions (2659 KB)
References
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Tubercidin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Tubercidin69-33-07-DeazaadenosineBacterialDNA/RNA SynthesisInfluenza VirusAntibioticInhibitorinhibitorinhibit

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