1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
    DNA/RNA Synthesis
  3. Tubercidin

Tubercidin (Synonyms: 7-Deazaadenosine)

Cat. No.: HY-100126 Purity: 98.68%
Handling Instructions

Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus, it inhibits the growth of Streptococcus faecalis (8043) by IC50 of 0.02 μM. Tubercidin (7-Deazaadenosine) inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis. Tubercidin (7-Deazaadenosine) is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP.

For research use only. We do not sell to patients.

Tubercidin Chemical Structure

Tubercidin Chemical Structure

CAS No. : 69-33-0

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10 mM * 1 mL in DMSO USD 106 In-stock
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100 mg USD 420 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus, it inhibits the growth of Streptococcus faecalis (8043) by IC50 of 0.02 μM[1]. Tubercidin (7-Deazaadenosine) inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin (7-Deazaadenosine) is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1].

In Vitro

Tubercidin (7-Deazaadenosine) (0-10 nM; 14 days) has a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells, and the IC50s of tubercidin were 3.4 nM and 3.7 nM for CFU-GM and BFU-E, respectively[2].

Cell Cytotoxicity Assay[2]

Cell Line: Human bone marrow progenitor cells
Concentration: 0-10 nM
Incubation Time: 14 days
Result: Had a dose-dependent inhibitory effect for CFU-GM and BFU-E.
In Vivo

Tubercidin (7-Deazaadenosine) (intraperitoneal injection; 5 mg/kg; 10 days) in cooperation with NBMPR-P protects the mice from the lethality of tubercidin and allowed the repetition of the regimen for a second time with 100% survival[2].

Animal Model: Female CD1 mice[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg; 10 days
Result: Protected the mice from the lethality of tubercidin.
Molecular Weight

266.25

Formula

C₁₁H₁₄N₄O₄

CAS No.

69-33-0

SMILES

NC1=C2C(N([[email protected]]3[[email protected]@H]([[email protected]@H]([[email protected]@H](CO)O3)O)O)C=C2)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (112.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7559 mL 18.7793 mL 37.5587 mL
5 mM 0.7512 mL 3.7559 mL 7.5117 mL
10 mM 0.3756 mL 1.8779 mL 3.7559 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.68%

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Tubercidin
Cat. No.:
HY-100126
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