1. Anti-infection
  2. Bacterial

Tubercidin (Synonyms: 7-Deazaadenosine; Sparsomycin A)

Cat. No.: HY-100126 Purity: 98.68%
Handling Instructions

Tubercidin (7-Deazaadenosine) is an adenosine analog, is an antibiotic obtained from Streptomyces tubercidicus.

For research use only. We do not sell to patients.

Tubercidin Chemical Structure

Tubercidin Chemical Structure

CAS No. : 69-33-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 336 In-stock
Estimated Time of Arrival: December 31
100 mg USD 420 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Tubercidin (7-Deazaadenosine) is an adenosine analog, is an antibiotic obtained from Streptomyces tubercidicus. Target: Antibacterial Tubercidin inhibits the growth of Streptococcus faecalis by 50 % at a concentration of 20 nM. Tubercidin is not subject to cleavage by adenosine phosphorylase or to deamination by adenosine deaminase. The antibiotic served as a substrate for numerous enzymes involved in the anabolism of adenosine, as demonstrated by its incorporation into RNA and DNA, and by the formation of nicotinamide-deaza-adenine dinucleotide. Tubercidin proves to be a weak inhibitor of adenosine phosphorylase, and interfered with the phosphorylation of adenosine and AMP. The inhibition of the growth of S. faecalis by Tubercidin is prevented by purine and pyrimidine nucleosides, ribose 5-phosphate, pyruvate, and certain amino acids. In the presence of Tubercidin, growing cultures of the test organism used pyruvate instead of glucose, whereas in the absence of the antibiotic glucose served as the main source of energy. It is suggested, therefore, that the impairment of growth is due primarily to the interference of Tubercidin with the utilization of glucose.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (112.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7559 mL 18.7793 mL 37.5587 mL
5 mM 0.7512 mL 3.7559 mL 7.5117 mL
10 mM 0.3756 mL 1.8779 mL 3.7559 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

266.25

Formula

C₁₁H₁₄N₄O₄

CAS No.

69-33-0

SMILES

NC1=C2C(N([[email protected]]3[[email protected]@H]([[email protected]@H]([[email protected]@H](CO)O3)O)O)C=C2)=NC=N1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.68%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Product Name:
Tubercidin
Cat. No.:
HY-100126
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Tubercidin

Cat. No.: HY-100126