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  3. Peldesine dihydrochloride

Peldesine dihydrochloride (Synonyms: BCX 34 dihydrochloride)

Cat. No.: HY-106934A Purity: 99.80%
Handling Instructions

Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.

For research use only. We do not sell to patients.

Peldesine dihydrochloride Chemical Structure

Peldesine dihydrochloride Chemical Structure

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 462 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 700 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research[1][2][3][4].

IC50 & Target

IC50: 36 nM (Human RBC PNP), 5 nM (Rat RBC PNP), 32 nM (Mouse RBC PNP), and 800 nM (Human T-cell proliferation)[3]
Ki: 23 nM (Human RBC PNP)[3]
HIV[4]

In Vitro

Peldesine (BCX 34; 0-50 µM; 72 hours; Jurkat cells) could inhibit the T-cell proliferation completely at a concentration of less than 10 μM, in the presence of dGuo (10 μM). In contrast, the B-cell proliferation is not affected by Peldesine[1].
Peldesine (BCX 34) suppresses T-cell immune reaction in an IL-2-independent manner, and this means that Peldesine might affect a late phase rather than an early stage in T-cell activation[1].
Peldesine also, in the presence but not in the absence of deoxyguanosine, inhibits human leukemia CCRF-CEM T-cell proliferation with an IC50 of 0.57 μM but not rat or mouse T-cell proliferation up to 30 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 0-50 µM
Incubation Time: 72 hours
Result: In the presence of 10 µM dCuo, had a complete inhibitory effect for T-cell lines.
Clinical Trial
Molecular Weight

314.17

Formula

C₁₂H₁₃Cl₂N₅O

SMILES

Cl[H].O=C1C(NC=C2CC3=CC=CN=C3)=C2N=C(N)N1.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (636.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1830 mL 15.9150 mL 31.8299 mL
5 mM 0.6366 mL 3.1830 mL 6.3660 mL
10 mM 0.3183 mL 1.5915 mL 3.1830 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

PeldesineBCX 34BCX34BCX-34Nucleoside Antimetabolite/AnalogHIVHuman immunodeficiency virusnucleosidephosphorylaseT-cellPNPimmunosuppressivedGuoIL-2inosinepsoriasislymphomaInhibitorinhibitorinhibit

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Product Name:
Peldesine dihydrochloride
Cat. No.:
HY-106934A
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