2-Deoxy-L-ribose
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase.
For research use only. We do not sell to patients.
- CAS No.: 18546-37-7
- Formula: C5H10O4
- Molecular Weight:134.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
2-Deoxy-L-ribose (10-100 μM; 24 h) significantly reduces the number of invading KB/TP cells under hypoxia[1].
2-Deoxy-L-ribose (10-100 μM; 48 h) decreases VEGF and IL-8 mRNA levels in KB/TP cells under hypoxia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KB/TP cells (thymidine phosphorylase (TP)-overexpressing human epidermoid carcinoma)
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Concentration:10 μM or 100 μM
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Incubation Time:24 hours
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Result:Inhibited TP-overexpressing tumor cell invasion in vitro.
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Cell Line:KB/TP cells (thymidine phosphorylase (TP)-overexpressing human epidermoid carcinoma)
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Concentration:10 μM or 100 μM
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Incubation Time:48 hours
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Result:
2-Deoxy-L-ribose (20 mg/kg; p.o.; daily; 52 days) showes superior efficacy to Tegafur (HY-17400) (100 mg/kg) in reducing abdominal metastatic nodules[1].
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice intrasplenically injected with KB/TP cells[1]
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Dosage:20 mg/kg/day or 100 mg/kg/day
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Administration:Oral (p.o.), daily for 28 days
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Result:Effectively inhibited TP-mediated liver metastasis and angiogenesis.
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Animal Model:BALB/c nude mice with subcutaneous KB/TP cell injection[1]
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Dosage:20 mg/kg/day
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Administration:Oral (p.o.), daily until day 52
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Result:Decreased the number of metastatic nodules in organs.
Chemical Information
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CAS No. 18546-37-7
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Appearance Solid
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Molecular Weight 134.13
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Formula C5H10O4
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Color White to light yellow
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SMILES
O=CC[C@H]([C@H](CO)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Deoxy-L-ribose Related Classifications
HY-W012670 Related Classifications
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