2-Deoxy-L-ribose
Based on 1 Customer Validation
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 18546-37-7
- 화학식: C5H10O4
- 분자량:134.13
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
2-Deoxy-L-ribose (10-100 μM; 24 h) significantly reduces the number of invading KB/TP cells under hypoxia[1].
2-Deoxy-L-ribose (10-100 μM; 48 h) decreases VEGF and IL-8 mRNA levels in KB/TP cells under hypoxia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:KB/TP cells (thymidine phosphorylase (TP)-overexpressing human epidermoid carcinoma)
-
Concentration:10 μM or 100 μM
-
Incubation Time:24 hours
-
Result:Inhibited TP-overexpressing tumor cell invasion in vitro.
-
Cell Line:KB/TP cells (thymidine phosphorylase (TP)-overexpressing human epidermoid carcinoma)
-
Concentration:10 μM or 100 μM
-
Incubation Time:48 hours
-
Result:
2-Deoxy-L-ribose (20 mg/kg; p.o.; daily; 52 days) showes superior efficacy to Tegafur (HY-17400) (100 mg/kg) in reducing abdominal metastatic nodules[1].
.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c nude mice intrasplenically injected with KB/TP cells[1]
-
Dosage:20 mg/kg/day or 100 mg/kg/day
-
Administration:Oral (p.o.), daily for 28 days
-
Result:Effectively inhibited TP-mediated liver metastasis and angiogenesis.
-
Animal Model:BALB/c nude mice with subcutaneous KB/TP cell injection[1]
-
Dosage:20 mg/kg/day
-
Administration:Oral (p.o.), daily until day 52
-
Result:Decreased the number of metastatic nodules in organs.
Chemical Information
-
CAS No. 18546-37-7
-
Appearance Solid
-
분자량 134.13
-
화학식 C5H10O4
-
Color White to light yellow
-
SMILES
O=CC[C@H]([C@H](CO)O)O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
-
Data Sheet (270 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Deoxy-L-ribose Related Classifications
HY-W012670 Related Classifications
Powered by Bioz