2'-Deoxyadenosine 5'-di-phos-phate disodium
Based on 1 Customer Validation
2'-Deoxyadenosine 5'-diphosphate disodium (dADP disodium) is an inhibitor of Polynucleotide phosphorylase and Polyadenylate polymerase. 2'-Deoxyadenosine 5'-diphosphate disodium inhibits polyadenylate synthesis in permeabilized bacterial cells. As a chelating agent, 2'-Deoxyadenosine 5'-diphosphate disodium forms 1:1 complexes with trivalent lanthanides, Manganese (II) and Copper (II) ions, with unique coordination modes and structural conformations for each ion type.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 72003-83-9
- Formula: C10H13N5Na2O9P2
- Molecular Weight:455.17
-
Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
2'-Deoxyadenosine 5'-diphosphate (0.25 mM) disodium strongly inhibits poly(A) synthesis in toluene-treated permeable Escherichia coli cells, with 0.25 mM dADP reducing activity by over 90%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 72003-83-9
-
Appearance Solid
-
Molecular Weight 455.17
-
Formula C10H13N5Na2O9P2
-
Color White to light yellow
-
SMILES
O[C@H]1C[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(OP(O)(O[Na])=O)(O[Na])=O
-
Synonyms
dADP disodium
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 250 mg/mL (549.25 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
-
Handling Instructions (2659 KB)
References
[1]. Deutscher MP, et al. Synthesis and degradation of poly(A) in permeable cells of Escherichia coli. The Journal of biological chemistry. 1978 Aug 25;253(16):5579-84. [Content Brief]
[2]. Fazakerley GV, et al. Determination of the interaction of ADP and dADP with copper(II), manganese(II) and lanthanide(III) ions by nuclear-magnetic-resonance spectroscopy. European journal of biochemistry. 1979 Feb 01;93(3):535-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.1970 mL | 10.9849 mL | 21.9698 mL | 54.9245 mL |
| 5 mM | 0.4394 mL | 2.1970 mL | 4.3940 mL | 10.9849 mL | |
| 10 mM | 0.2197 mL | 1.0985 mL | 2.1970 mL | 5.4925 mL | |
| 15 mM | 0.1465 mL | 0.7323 mL | 1.4647 mL | 3.6616 mL | |
| 20 mM | 0.1098 mL | 0.5492 mL | 1.0985 mL | 2.7462 mL | |
| 25 mM | 0.0879 mL | 0.4394 mL | 0.8788 mL | 2.1970 mL | |
| 30 mM | 0.0732 mL | 0.3662 mL | 0.7323 mL | 1.8308 mL | |
| 40 mM | 0.0549 mL | 0.2746 mL | 0.5492 mL | 1.3731 mL | |
| 50 mM | 0.0439 mL | 0.2197 mL | 0.4394 mL | 1.0985 mL | |
| 60 mM | 0.0366 mL | 0.1831 mL | 0.3662 mL | 0.9154 mL | |
| 80 mM | 0.0275 mL | 0.1373 mL | 0.2746 mL | 0.6866 mL | |
| 100 mM | 0.0220 mL | 0.1098 mL | 0.2197 mL | 0.5492 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2'-Deoxyadenosine 5'-di-phos-phate disodium Related Classifications
HY-W010854 Related Classifications
Powered by Bioz