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Benzylacyclouridine (Synonyms: BAU; 5-Benzylacyclouridine)

Cat. No.: HY-106406
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Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives.

For research use only. We do not sell to patients.

Benzylacyclouridine Chemical Structure

Benzylacyclouridine Chemical Structure

CAS No. : 82857-69-0

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Description

Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives[1][2][3].

IC50 & Target

uridine phosphorylase[1]

In Vitro

Benzylacyclouridine increases 5-FU-induced cytotoxicity in a number of human cancer cell lines[1].
Benzylacyclouridine (20-100 μM) reduces the rapid clearance of trace amounts of either [14C]uridine or hyperphysiologic concentrations of non-labeled uridine by the isolated rat liver perfused with an artificial oxygen carrier[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzylacyclouridine (p.o. or i.v.) arrests the rapid degradation of a tracer dose of uridine into uracil in dogs and pigs[1].
Benzylacyclouridine exhibits the t1/2 of 1.8-3.6 h in dogs, with bioavailability levels of 85% (30 mg/kg) and 42.5% (120 mg/kg)[1].
Benzylacyclouridine (120 mg/kg) exhibits the t1/2 of 1.6-2.3 h, with a bioavailability of 40% in pigs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.29

Formula

C₁₄H₁₆N₂O₄

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Benzylacyclouridine
Cat. No.:
HY-106406
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