82857-69-0
82857-69-0
Chemical Structure
Benzylacyclouridine
Synonym(s): BAU; 5-Benzylacyclouridine
- CAS No.: 82857-69-0
- Formula:C14H16N2O4
- Molecular Weight:276.29
IUPAC Name: 5-benzyl-1-((2-hydroxyethoxy)methyl)pyrimidine-2,4(1H,3H)-dione
InChIKey: SPJAGILXQBHHSZ-UHFFFAOYSA-N
SMILES: OCCOCN(C(NC1=O)=O)C=C1CC2=CC=CC=C2
Biological Activity: Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine inhibits the metabolic activity of UPP1 and the activity of UPP2. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Benzylacyclouridine | 98.02% | Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine inhibits the metabolic activity of UPP1 and the activity of UPP2. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Benzylacyclouridine (Standard) | ≥98% | Benzylacyclouridine (Standard) is the analytical standard of Benzylacyclouridine. This product is intended for research and analytical applications. Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Pizzorno G, et, al. Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor. Clin Cancer Res. 1998 May;4(5):1165-75. [Content Brief]
- [2]. Monks A, et, al. Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver. Biochem Pharmacol. 1983 Jul 1;32(13):2003-9. [Content Brief]
- [3]. Roosild TP, et, al. Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. BMC Struct Biol. 2009 Mar 16;9:14. [Content Brief]
- [4]. Whyte D, et al. Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. EMBO Rep. 2025 Jul 23. [Content Brief]
- [5]. Sohn JH, et al. Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism. Cell Metab. 2023 Aug 8;35(8):1356-1372.e5. [Content Brief]
