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Results for "

retinoids

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AP-1 (2) Apoptosis (22) Autophagy (32) Calcium Channel (3) Caspase (1) Cathepsin (1) Drug Derivative (6) Drug Metabolite (6) Endogenous Metabolite (6) Environmental Pollutants (1) Glutathione S-transferase (3) HCV (2) Interleukin Related (1) Isotope-Labeled Compounds (11) Lipocalin Family (2) LXR (1) NF-κB (3) NO Synthase (2) Organoid (2) RAR/RXR (62) Reactive Oxygen Species (ROS) (3) Reference Standards (18) ROR (7) SARS-CoV (1) SphK (2) TNF Receptor (1) TRP Channel (1) Tyrosine Hydroxylase (1) VD/VDR (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (58) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (30) Metabolic Disease (13) Neurological Disease (20)

By Targets:

Akt (1)

AP-1 (2)

Apoptosis (22)

Autophagy (32)

Calcium Channel (3)

Caspase (1)

Cathepsin (1)

Drug Derivative (6)

Drug Metabolite (6)

Endogenous Metabolite (6)

Environmental Pollutants (1)

Glutathione S-transferase (3)

HCV (2)

Interleukin Related (1)

Isotope-Labeled Compounds (11)

Lipocalin Family (2)

LXR (1)

NF-κB (3)

NO Synthase (2)

Organoid (2)

RAR/RXR (62)

Reactive Oxygen Species (ROS) (3)

Reference Standards (18)

ROR (7)

SARS-CoV (1)

SphK (2)

TNF Receptor (1)

TRP Channel (1)

Tyrosine Hydroxylase (1)

VD/VDR (3)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (58)

Cardiovascular Disease (1)

Infection (3)

Inflammation/Immunology (30)

Metabolic Disease (13)

Neurological Disease (20)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14171

Bexarotene 20+ Cited Publications LGD1069	RAR/RXR Autophagy	Cancer
Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-N0155

Nobiletin 25+ Cited Publications	ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-15870

SR 11302 20+ Cited Publications	AP-1	Inflammation/Immunology Cancer
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .

HY-15373

Fenretinide 5+ Cited Publications 4-HPR; ISLA-101	RAR/RXR Autophagy	Cancer
Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.

HY-U00449

AGN 193109 5+ Cited Publications	RAR/RXR	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with K_ds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-B0091

Adapalene 5 Publications Verification CD271	RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-W009310

9-cis-Retinal	Endogenous Metabolite Organoid	Others
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with K_ds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids .

HY-B0107

Acitretin 4 Publications Verification Ro 10-1670	RAR/RXR Autophagy Apoptosis	Inflammation/Immunology Cancer
Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin also can be used for the research of Alzheimer’s disease .

HY-107500

UVI 3003 5+ Cited Publications	RAR/RXR Autophagy	Others
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC₅₀s of 0.22 and 0.24 μM, respectively.

HY-P0109A

Z-FA-FMK 5+ Cited Publications (1S)-Z-FA-FMK	SARS-CoV Cathepsin Apoptosis Caspase	Infection Cancer
Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .

HY-15340

LG100268 5 Publications Verification LG268	RAR/RXR Autophagy	Metabolic Disease
LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC₅₀ values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the K_i values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .

HY-107397

Ch55 2 Publications Verification	RAR/RXR	Cancer
Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC₅₀ of 200 nM. Ch55 can be used for cancer research .

HY-107399

CD3254 3 Publications Verification	RAR/RXR	Metabolic Disease Cancer
CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .

HY-A0067

Oxybenzone 5+ Cited Publications Benzophenone 3	Environmental Pollutants Autophagy RAR/RXR Apoptosis	Neurological Disease
Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	VD/VDR Drug Metabolite Endogenous Metabolite	Metabolic Disease
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-100608

BMS453 1 Publications Verification BMS-189453	RAR/RXR	Cancer
BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ .

HY-12309

EC23 AGN 190205; BASF-46928	Organoid	Neurological Disease
EC23 (AGN 190205) is a stable synthetic retinoid analogue and induces neuronal differentiation .

HY-100008

Peretinoin 5+ Cited Publications NIK333	RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC₅₀ of 9 μM .

HY-107436

LE135 4 Publications Verification	RAR/RXR TRP Channel	Neurological Disease Cancer
LE135 is a potent RAR antagonist that binds selectively to RARα (K_i of 1.4 μM) and RARβ (K_i of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent TRPV1 and TRPA1 receptors activator with EC₅₀s of 2.5 μM and 20 μM, respectively .

HY-101108

Tazarotenic acid 2 Publications Verification AGN 190299	Drug Metabolite	Others
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-B0797

Etretinate 1 Publications Verification Ro 10-9359	Apoptosis	Others
Etretinate(Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis treatment.

HY-132810

Bevurogant BI 730357	ROR	Inflammation/Immunology Cancer
Bevurogant (BI 730357) is a retinoid-related orphan receptor-gamma t (RORγt) antagonist. Bevurogant can be used for the research of chronic inflammatory diseases .

HY-116506

Bigelovin	RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy	Cancer
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-153832

MSU-42011	RAR/RXR NO Synthase	Cancer
MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the iNOS activity and reduces the expression of p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity .

HY-14653

Amsilarotene TAC-101; Am 555S	RAR/RXR Apoptosis	Cancer
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with K_i of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer .

HY-W107616

3,7,11,15-Tetramethyl-2-hexadecen-1-ol	Endogenous Metabolite	Others
3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

HY-D1190

DC271	RAR/RXR	Others
DC271 is a RAR agonist and synthetic retinoid that binds to the retinoid-binding site of cellular retinoic acid-binding protein II (CRBP-II). DC271 exhibits solvatochromic fluorescence properties: it produces intense blue-shifted emission in nonpolar environments and weak red-shifted emission in polar environments, and its severe fluorescence quenching in aqueous solutions can be reversed by embedding in the hydrophobic retinoid-binding protein pocket. DC271 enables direct detection of the binding between unlabeled compounds and related retinoid-binding proteins via fluorescence competition assays (Ex/Em = 355 nm/460 nm) .

HY-120875

HX600	RAR/RXR	Neurological Disease
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity .

HY-B1640R

Ethacrynic acid (Standard) 5+ Cited Publications Etacrynic acid (Standard)	Reference Standards Glutathione S-transferase NF-κB Calcium Channel	Inflammation/Immunology Cancer
Ethacrynic acid (Standard) is the analytical standard of Ethacrynic acid. This product is intended for research and analytical applications. Ethacrynic acid (Etacrynic acid) is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .

HY-121435

K-8012	RAR/RXR Akt Apoptosis Drug Derivative TNF Receptor	Cancer
K-8012 is a Sulindac (HY-B0008) analog and RXRα antagonist with an IC₅₀ of 9.2 µM. K-8012 inhibits the activation of AKT. K-8012 induces Apoptosis, redirecting the TNFα signaling pathway from survival to death. K-8012 exerts anticancer activity against lung cancer, prostate cancer, and breast cancer. K-8012 can be used in research related to lung cancer, prostate cancer, breast cancer, and hepatocellular carcinoma .

HY-136554

WYC-210	Drug Derivative	Cancer
WYC-210, a Tazarotene derivative, is a retinoid compound with lower anticancer activity . WYC-210 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-106735

Arotinoid Ro 13-6298; Arotinoid ethyl ester	RAR/RXR	Inflammation/Immunology Cancer
Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED₅₀ of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas .

HY-14171S

Bexarotene-d4 LGD1069 d₄	RAR/RXR Autophagy	Cancer
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-124136

WYC-209 1 Publications Verification	RAR/RXR Apoptosis Autophagy	Cancer
WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC₅₀=0.19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity .

HY-15870A

(6E)-SR 11302	AP-1	Inflammation/Immunology Cancer
(6E)-SR 11302 is a E-isomer of SR 11302. SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) .

HY-A0067S

Oxybenzone-d5	RAR/RXR Apoptosis Autophagy	Neurological Disease
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-123623

Tinlarebant LBS-008; BPN-14967	Lipocalin Family	Others
Tinlarebant (LBS-008) is an orally active non-retinoid RBP4 (retinol-binding protein 4) antagonist. Tinlarebant can be used for the research of the Stargardt disease .

HY-B0091A

Adapalene sodium salt 5 Publications Verification CD 271 sodium salt	RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity .

HY-104070

LG-100064	RAR/RXR Autophagy	Cancer
LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC₅₀s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.

HY-108525

Fluorobexarotene	RAR/RXR	Cancer
Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a K_i value of 12 nM and an EC₅₀ value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene .

HY-144377

RXR antagonist 1	RAR/RXR	Neurological Disease Metabolic Disease Cancer
RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 shows potent RXR-antagonistic activity, with a pA₂ of 8.06. RXR antagonist 1 can be used for type 2 diabetes research .

HY-169863

DC360	RAR/RXR	Inflammation/Immunology
DC360 is a synthetic retinoid analogue of all-trans retinoic acid (ATRA) which induces RARβ expression. DC360 can be utilized in characterization of retinoid signalling pathways .

HY-155437

NEt-iFQ	RAR/RXR	Others
NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. NEt-iFQ selectively binds to RXR-LBP and fluoresces .

HY-117376

(all-E)-UAB30 UAB30	RAR/RXR	Cancer
(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC₅₀ of 34.7, 5.1, and 22.4 μM respectively .

HY-A0067R

Oxybenzone (Standard) Benzophenone 3 (Standard)	Reference Standards RAR/RXR Autophagy Apoptosis	Neurological Disease
Oxybenzone (Standard) is the analytical standard of Oxybenzone. This product is intended for research and analytical applications. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-N0155R

Nobiletin (Standard)	Reference Standards ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Nobiletin (Standard) is the analytical standard of Nobiletin. This product is intended for research and analytical applications. Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-118584

Ro 12-7310	Drug Derivative	Inflammation/Immunology
Ro 12-7310 is a synthetic retinoid, and can inhibit arachidonic acid release .

HY-126044

6-Hydroxy bexarotene	Endogenous Metabolite	Metabolic Disease
6-Hydroxy bexarotene is the main circulating metabolite of bexarotene, found in rats, dogs, and humans. Compared to the parent compound, 6-hydroxy-bexarotene shows a significantly reduced ability to bind to retinoid receptors and exhibits very minimal activity in activating retinoic acid receptors .

HY-118239

Re 80	Drug Derivative	Inflammation/Immunology
Re 80 is an anti-angiogenic agent and is a synthetic retinoid .

HY-160212

JP3000	RAR/RXR	Metabolic Disease
JP3000, a chemical probe, is an agonist of RXRA, RXRB, RXRG .

Cat. No.	Product Name	Type

HY-D1190

DC271

Fluorescent Dyes

DC271 is a RAR agonist and synthetic retinoid that binds to the retinoid-binding site of cellular retinoic acid-binding protein II (CRBP-II). DC271 exhibits solvatochromic fluorescence properties: it produces intense blue-shifted emission in nonpolar environments and weak red-shifted emission in polar environments, and its severe fluorescence quenching in aqueous solutions can be reversed by embedding in the hydrophobic retinoid-binding protein pocket. DC271 enables direct detection of the binding between unlabeled compounds and related retinoid-binding proteins via fluorescence competition assays (Ex/Em = 355 nm/460 nm) .

HY-107413G

SR11237

Fluorescent Dyes

SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .

Cat. No.	Product Name	Type

HY-107413G

SR11237

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P1861A

*Interphotoreceptor Retinoid* Binding Protein Fragment (IRBP) TFA**	Peptides	Inflammation/Immunology
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) TFA, a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU) .

HY-P5397A

IRBP derived peptide, R16 acetate 2 Publications Verification	Peptides	Others
IRBP derived peptide, R16 is a biological active peptide. (R16 is an IRBP (Interphotoreceptor retinoid binding protein) derived peptide. Photoreceptor cell protein is capable of inducing an experimental autoimmune uveitis (EAU) in susceptible animal strains.)

HY-P1861

*Interphotoreceptor Retinoid* Binding Protein Fragment (IRBP)**	Peptides	Inflammation/Immunology
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU) .

HY-P5397

IRBP derived peptide, R16	Peptides	Others
IRBP derived peptide, R16 is a biological active peptide. (R16 is an IRBP (Interphotoreceptor retinoid binding protein) derived peptide. Photoreceptor cell protein is capable of inducing an experimental autoimmune uveitis (EAU) in susceptible animal strains.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0155

Nobiletin 25+ Cited Publications	Flavonoids Neurological Disease Classification of Application Fields Flavones Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco Source Classification	ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-W009310

9-cis-Retinal	Classification of Application Fields Terpenoids Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Organoid
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with K_ds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids .

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	VD/VDR Drug Metabolite Endogenous Metabolite
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-116506

Bigelovin	Classification of Application Fields Ketones, Aldehydes, Acids Acacia auriculiformis A.Cunn. ex Benth Plants Compositae Disease Research Fields Cancer	RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-W107616

3,7,11,15-Tetramethyl-2-hexadecen-1-ol	Natural Products Rudbeckia laciniata L. Plants Compositae Source Classification	Endogenous Metabolite
3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

HY-N0155R

Nobiletin (Standard)	Structural Classification Flavonoids Flavones Rutaceae Plants Citrus reticulata Blanco Source Classification	Reference Standards ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy
Nobiletin (Standard) is the analytical standard of Nobiletin. This product is intended for research and analytical applications. Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-N2992

16α-Hydroxytrametenolic acid	Other Terpenoids Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Cancer Source Classification	RAR/RXR
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-129240

13-cis Acitretin Isoacitretin; Ro 13-7652	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Drug Derivative
13-cis Acitretin (Isoacitretin; Ro 13-7652) is a retinoid and the major in vivo metabolite of etretinate. 13-cis Acitretin is formed via in vivo isomerization of etretinate. 13-cis Acitretin serves as the primary metabolite in blood .

HY-N19756

Cochinchinone P	Structural Classification Flavonoids Cratoxylum cochinchinense (Lour.) Blume Hypericaceae Plants Other Flavonoids Source Classification	RAR/RXR
Cochinchinone P is a retinoid X receptor-α (RXRα) inhibitor that inhibits 9-cis-retinoic acid (HY-15128)-induced transcriptional activity of RXRα in vitro. Cochinchinone P can be used in cancer research .

HY-W107616R

3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard)	Structural Classification Natural Products Rudbeckia laciniata L. Plants Compositae Source Classification	Endogenous Metabolite Reference Standards
3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard) is the analytical standard of 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (HY-W107616). This product is intended for research and analytical applications. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

Cat. No.	Product Name	Chemical Structure

HY-14171S

Bexarotene-d4
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-A0067S

Oxybenzone-d5
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-B0797S

Etretinate-d3
Etretinate-d₃ is the deuterium labeled Etretinate. Etretinate (Ro 10-9359) is a second-generation retinoid that has the potential for severe psoriasis research.

HY-101108S

Tazarotenic acid-d6
Tazarotenic acid-d₆ is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-U00449S

AGN 193109-d7
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-129240S

13-cis Acitretin-d3
13-cis Acitretin-d₃ is a deuterium labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis .

HY-B0091S

Adapalene-d3
Adapalene-d₃ is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-101108S1

Tazarotenic acid-13C2,d2
Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-14171S2

Bexarotene-13C6

Bexarotene- ¹³C₆ (LGD1069- ¹³C₆) is ¹³C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-A0067S1

Oxybenzone-13C6

Oxybenzone- ¹³C₆ (Benzophenone 3- ¹³C₆) is the ¹³C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-W777169

Bexarotene-13C4
Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-W653958

Oxybenzone-d3

Oxybenzone-d₃ (Benzophenone 3-d₃) is a deuterium labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-32350S1

Ercalcitriol-d3

Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-W752012

Adapalene-13C6

Adapalene- ¹³C₆ (CD271- ¹³C₆) is the ¹³C-labeled Adapalene (HY-B0091). Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107413G

SR11237	RAR/RXR Tyrosine Hydroxylase	Neurological Disease Inflammation/Immunology
SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .

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