1. Metabolic Enzyme/Protease
    Apoptosis
  2. RAR/RXR
    Apoptosis
  3. WYC-209

WYC-209 

Cat. No.: HY-124136 Purity: 99.64%
Handling Instructions

WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity.

For research use only. We do not sell to patients.

WYC-209 Chemical Structure

WYC-209 Chemical Structure

CAS No. : 2131803-90-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity[1].

IC50 & Target

Retinoic acid receptor[1]

In Vitro

WYC-209 (10 μM; 24 hours) is able to inhibit and block growth of TRCs of human tumor cells in culture with a long-lasting effect[1].

Apoptosis Analysis[1]

Cell Line: A2780, A549, MCF-7, MDA-MB-435s, A375 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: TRCs failed to resume growth 5 days after the drug washout.
In Vivo

WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases[1].

Animal Model: Female immune-competent C57BL/6 mice[1]
Dosage: 0.022, 0.22 mg/kg
Administration: Intravenous injection; once every two days for 25 days
Result: Four out of eight mice formed lung metastases at dose of 0.022 mg /kg, only one out of eight mice formed lung metastases at dose of 0.22 mg/kg.
Molecular Weight

368.45

Formula

C₂₀H₂₀N₂O₃S

CAS No.

2131803-90-0

SMILES

O=C(C1=CN=C(C#CC2=CC=C3C(C(C)(C)CCS3=O)=C2)N=C1)OCC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (226.16 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7141 mL 13.5704 mL 27.1407 mL
5 mM 0.5428 mL 2.7141 mL 5.4281 mL
10 mM 0.2714 mL 1.3570 mL 2.7141 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
WYC-209
Cat. No.:
HY-124136
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