AGN-190121
AGN-190121 is a selective RARβ/γ retinoid agonist that inhibits IL-6 expression and cell proliferation in cancer cells by antagonizing NF-IL6. AGN-190121 can be used for the research of Kaposi's sarcoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 132032-67-8
- 分子式: C20H22O2
- 分子量:294.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
IL-6 |
体外実験
AGN-190121 (0-1 μM; 5 days) inhibits the proliferation of KS-29 cells in vitro with an IC50 of 50 nM; it also inhibits the proliferation of KS-59 cells with an IC50 of 100 nM[1].
AGN-190121 (1 μM; 36 h) inhibits NF-IL6-dependent gene expression via RARα and RARβ in transfected HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KS-29, KS-59
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Concentration:0.1, 1, 10, 100, 1000 nM
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Incubation Time:treated on days 1 and 3, counted on day 5
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Result:Inhibited the growth of KS-29 and KS-59 cells in a dose-dependent manner.
Exhibited an IC50 of 50 nM for KS-29 cells.
Exhibited an IC50 of 100 nM for KS-59 cells.
- RNA extraction experimental
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
化学情報
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CAS 番号 132032-67-8
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分子量 294.39
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分子式 C20H22O2
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SMILES
C(=C/C#CC1=CC=C(C(O)=O)C=C1)\C=2C(C)(C)CCCC2C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AGN-190121 関連分類
HY-165521 関連分類
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