2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Immunology/Inflammation
  3. RAR/RXR Interleukin Related
  4. AGN-190121

AGN-190121 is a selective RARβ/γ retinoid agonist that inhibits IL-6 expression and cell proliferation in cancer cells by antagonizing NF-IL6. AGN-190121 can be used for the research of Kaposi's sarcoma.

For research use only. We do not sell to patients.

AGN-190121

AGN-190121 Chemical Structure

CAS No. : 132032-67-8

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AGN-190121 Related Antibodies

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Description

AGN-190121 is a selective RARβ/γ retinoid agonist that inhibits IL-6 expression and cell proliferation in cancer cells by antagonizing NF-IL6. AGN-190121 can be used for the research of Kaposi's sarcoma[1].

IC50 & Target[1]

IL-6

 

In Vitro

AGN-190121 (0-1 μM; 5 days) inhibits the proliferation of KS-29 cells in vitro with an IC50 of 50 nM; it also inhibits the proliferation of KS-59 cells with an IC50 of 100 nM[1].
AGN-190121 (1 μM; 36 h) inhibits NF-IL6-dependent gene expression via RARα and RARβ in transfected HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AGN-190121 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: KS-29, KS-59
Concentration: 0.1, 1, 10, 100, 1000 nM
Incubation Time: treated on days 1 and 3, counted on day 5
Result: Inhibited the growth of KS-29 and KS-59 cells in a dose-dependent manner.
Exhibited an IC50 of 50 nM for KS-29 cells.
Exhibited an IC50 of 100 nM for KS-59 cells.
Molecular Weight

294.39

Formula

C20H22O2
CAS No.
SMILES

C(=C/C#CC1=CC=C(C(O)=O)C=C1)\C=2C(C)(C)CCCC2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AGN-190121 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGN-190121132032-67-8AGN190121AGN 190121RAR/RXRInterleukin RelatedRetinoic acid receptorsRetinoid X receptorsILKS-29 cellsKaposi's sarcomaKaposi's sarcoma spindle cell strainsRARβRARγHeLa cellsinterleukin-6KS cellsretinoid acid receptorsNF-IL6Inhibitorinhibitorinhibit

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AGN-190121
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HY-165521
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