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Cat. No.: HY-165521

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AGN-190121

AGN-190121 is a selective RARβ/γ retinoid agonist that inhibits IL-6 expression and cell proliferation in cancer cells by antagonizing NF-IL6. AGN-190121 can be used for the research of Kaposi's sarcoma.

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CAS No.: 132032-67-8
화학식: C₂₀H₂₂O₂
분자량:294.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AGN-190121 Chemical Structure

CAS No.: 132032-67-8

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

IL-6

All RAR/RXR Isoforms :

All Interleukin Related Isoforms :

In Vitro

AGN-190121 (0-1 μM; 5 days) inhibits the proliferation of KS-29 cells in vitro with an IC₅₀ of 50 nM; it also inhibits the proliferation of KS-59 cells with an IC₅₀ of 100 nM^[1].
AGN-190121 (1 μM; 36 h) inhibits NF-IL6-dependent gene expression via RARα and RARβ in transfected HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

KS-29, KS-59
Concentration:

0.1, 1, 10, 100, 1000 nM
Incubation Time:

treated on days 1 and 3, counted on day 5
Result:

Inhibited the growth of KS-29 and KS-59 cells in a dose-dependent manner.
Exhibited an IC₅₀ of 50 nM for KS-29 cells.
Exhibited an IC₅₀ of 100 nM for KS-59 cells.

Related Protocols :

Chemical Information

CAS No. 132032-67-8
분자량 294.39
화학식 C₂₀H₂₂O₂
SMILES

C(=C/C#CC1=CC=C(C(O)=O)C=C1)\C=2C(C)(C)CCCC2C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Nagpal S, et al. Retinoid antagonism of NF-IL6: insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma. Mol Cell Biol. 1997;17(7):4159-4168. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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CAS No.:
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Purity:
수량:

AGN-190121

All RAR/RXR Isoforms

All Interleukin Related Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AGN-190121 Related Classifications

HY-165521 Related Classifications

Bioz

Keywords

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