Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)

Cat. No.: HY-P1861: FAQs
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Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU).

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Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) Chemical Structure

CAS No. : 211426-18-5

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Other In-stock Forms of Interphotoreceptor Retinoid Binding Protein Fragment (IRBP):

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) (TFA)

Other Forms of Interphotoreceptor Retinoid Binding Protein Fragment (IRBP):

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) (TFA) In-stock

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Description	Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU)^[1].
Molecular Weight	2209.50
Formula	C₁₀₃H₁₅₇N₂₅O₂₉
CAS No.	211426-18-5
Sequence	Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp
Sequence Shortening	SGIPYIISYLHPGNTILHVD
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. Tang J, et al. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signatureand is driven by unique effector mechanisms: initial encounter with autoantigen defines diseasephenotype. J Immunol. 2007 May 1;178(9):5578-87. [Content Brief] [2]. Cortes LM, et al. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinalautoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol. 2008 Aug;84(2):577-85. [Content Brief] [3]. Yang H, et al. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804. [Content Brief]

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)211426-18-5OthersInhibitorinhibitorinhibit

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Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)

Other Forms of Interphotoreceptor Retinoid Binding Protein Fragment (IRBP):