2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. Endogenous Metabolite HDAC STAT Apoptosis
  4. 1-Stearoyl-sn-glycero-3-phosphocholine

1-Stearoyl-sn-glycero-3-phosphocholine  (Synonyms: 18:0 Lyso-PC; LPC(18:0))

製品番号: HY-125771 純度: 99.53%
COA 取扱説明書 Technical Support

1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells.

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1-Stearoyl-sn-glycero-3-phosphocholine

1-Stearoyl-sn-glycero-3-phosphocholine 構造式

CAS 番号 : 19420-57-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
25 mg $30 在庫あり
50 mg $50 在庫あり
100 mg $80 在庫あり
250 mg $140 在庫あり
500 mg $225 在庫あり
1 g $360 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of 1-Stearoyl-sn-glycero-3-phosphocholine:

1-Stearoyl-sn-glycero-3-phosphocholine 関連抗体

Top Publications Citing Use of Products

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

HDAC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

STAT アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
STAT3 STAT5 STAT6 STAT1

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製品説明

1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells[1].

IC50 & Target[1]

HDAC3

 

p-STAT3

 

体外実験

1-Stearoyl-sn-glycero-3-phosphocholine (10-80 μM; 24-72 h) significantly reduces the viability of K562, HL-60, U937 and MDA - MB-231 cells[1].
1-Stearoyl-sn-glycero-3-phosphocholine (80 μM; 24 h) induces apoptosis in K562, U937 and HL-60 cells, and significantly increases the sub-G1 cell population in K562 cells[1].
1-Stearoyl-sn-glycero-3-phosphocholine (80 μM; 24 h) induces the cleavage of caspase-9, caspase 3 and PARP, enhances the levels of acetyl - histone H3 at Lys 18 and 23, reduces the expression of HDAC3, inhibits the phosphorylation of STAT3 at Ser 727 and Tyr 705, and downregulates the expression of survival genes such as Cyclin D1, Cyclin E, Bcl-xL, Bcl-2 and survivin in K562 cells[1].
K562 80 μM 24 h Induced apoptosis. K562 80 μM 24 h The sub-G1 cell population was significantly increased. K562 80 μM 24 h Downregulated the expression of survival genes such as Cyclin D1, Cyclin E, Bcl-xL, Bcl-2, and survivin. K562 0 μM, 10 μM, 20 μM, 40 μM, 80 μM 24 h Induced the cleavage of caspase-9, caspase 3, and PARP. It also enhanced the levels of acetyl - histone H3 at Lys 18 and 23, reduced the expression of HDAC3, inhibited the phosphorylation of STAT3 at Ser 727 and Tyr 705.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Stearoyl-sn-glycero-3-phosphocholine 関連抗体

Cell Viability Assay[1]

Cell Line: K562 cells
Concentration: 0 μM, 10 μM, 20 μM, 40 μM, 80 μM
Incubation Time: 24, 48 and 72 h
Result: Decreased cell viability in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: K562 cells
Concentration: 80 μM
Incubation Time: 24 h
Result: Induced apoptosis.

Cell Cycle Analysis[1]

Cell Line: K562 cells
Concentration: 80 μM
Incubation Time: 24 h
Result: The sub-G1 cell population was significantly increased.

RT-PCR[1]

Cell Line: K562 cells
Concentration: 80 μM
Incubation Time: 24 h
Result: Downregulated the expression of survival genes such as Cyclin D1, Cyclin E, Bcl-xL, Bcl-2, and survivin.

Western Blot Analysis[1]

Cell Line: K562 cells
Concentration: 0 μM, 10 μM, 20 μM, 40 μM, 80 μM
Incubation Time: 24 h
Result: Induced the cleavage of caspase-9, caspase 3, and PARP. It also enhanced the levels of acetyl-histone H3 at Lys 18 and 23, reduced the expression of HDAC3, inhibited the phosphorylation of STAT3 at Ser 727 and Tyr 705.
分子量

523.68

分子式

C26H54NO7P
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCCCC(OC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 25 mg/mL (47.74 mM; Need ultrasonic)

Ethanol : 12.5 mg/mL (23.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9096 mL 9.5478 mL 19.0956 mL
5 mM 0.3819 mL 1.9096 mL 3.8191 mL
10 mM 0.1910 mL 0.9548 mL 1.9096 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (2.39 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (2.39 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.53%

COA (240 KB) HNMR (260 KB) RP-HPLC (249 KB) MS (81 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / H2O 1 mM 1.9096 mL 9.5478 mL 19.0956 mL 47.7391 mL
5 mM 0.3819 mL 1.9096 mL 3.8191 mL 9.5478 mL
10 mM 0.1910 mL 0.9548 mL 1.9096 mL 4.7739 mL
15 mM 0.1273 mL 0.6365 mL 1.2730 mL 3.1826 mL
20 mM 0.0955 mL 0.4774 mL 0.9548 mL 2.3870 mL
H2O 25 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9096 mL
30 mM 0.0637 mL 0.3183 mL 0.6365 mL 1.5913 mL
40 mM 0.0477 mL 0.2387 mL 0.4774 mL 1.1935 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Stearoyl-sn-glycero-3-phosphocholine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Stearoyl-sn-glycero-3-phosphocholine19420-57-618:0 Lyso-PCLPC(18:0)Endogenous MetaboliteHDACSTATApoptosisHistone deacetylasesbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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製品名:
1-Stearoyl-sn-glycero-3-phosphocholine
製品番号:
HY-125771
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