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Results for "

Amino acid Transporter

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (2) Amino acid Transporter (6) EAAT (18) Adrenergic Receptor (1) Apoptosis (3) ASCT (7) Biochemical Assay Reagents (3) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (11) Environmental Pollutants (1) GABA Receptor (4) GlyT (5) iGluR (1) Isotope-Labeled Compounds (3) NO Synthase (5) Nuclear Hormone Receptor 4A/NR4A (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5)
By Research Areas:	Cancer (20) Cardiovascular Disease (5) Infection (1) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (20)
Oligonucleotides:	Solubilizing Agents (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Amino Acid Decarboxylase Amino Acid Oxidase Amino Acid Derivatives Amino acid Transporter Branched Chain Amino Acid Transaminase (BCAT) EAAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0455

L-Arginine 20+ Cited Publications	Environmental Pollutants Endogenous Metabolite NO Synthase	Cardiovascular Disease Inflammation/Immunology
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-B1102

Evans Blue 25+ Cited Publications Direct Blue 53; T-1824; C.I. 23860	EAAT iGluR	Cardiovascular Disease Neurological Disease
Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound *excitatory amino* acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor**-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .

HY-112683

V-9302 Maximum Cited Publications 34 Publications Verification	ASCT	Cancer
V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 inhibits ASCT2-mediated glutamine uptake (IC₅₀=9.6 μM) in HEK-293 cells .

HY-108540

BCH 10+ Cited Publications 2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1	Apoptosis	Cancer
BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of *large neutral amino* acid transporter 1 (LAT1)** significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis .

HY-N0455A

L-Arginine hydrochloride Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine hydrochloride	NO Synthase Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-101037

Sarcosine 3 Publications Verification N-Methylglycine; Sarcosin	Endogenous Metabolite GlyT	Cancer
Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive *glycine transporter* type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor** co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-112683A

V-9302 hydrochloride Maximum Cited Publications 34 Publications Verification	ASCT	Cancer
V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC₅₀=9.6 µM) in HEK-293 cells .

HY-107522

DL-TBOA 1 Publications Verification	EAAT	Neurological Disease
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for *excitatory amino* acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [ ¹⁴C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with K_i** values of 4.4 μM and 3.2 μM, respectively .

HY-120139

KMH-233 1 Publications Verification	Amino acid Transporter	Cancer
KMH-233, a potent, reversible and selective inhibitor of *l-type amino* acid transporter LAT1/SLC7A5**, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) .

HY-W087830

L-p-Boronophenylalanine L-BPA	Biochemical Assay Reagents	Cancer
L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (L_AT1 and L_AT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma .

HY-Y1147

Diethyl maleate 1 Publications Verification Maleic acid diethyl ester	Biochemical Assay Reagents	Others
Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

HY-10914

UCPH-101 1 Publications Verification	EAAT	Neurological Disease
UCPH-101 is an *excitatory amino* acid transporter subtype 1 (EAAT1) inhibitor with an IC₅₀** of 0.66 μM.

HY-12741

LDN-212320 5+ Cited Publications LDN-0212320; OSU-0212320	EAAT	Neurological Disease
LDN-212320 (LDN-0212320) is a *glutamate transporter* (GLT-1)/excitatory amino acid transporter 2 (EAAT2)** activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC ^[1]

HY-114381

GT 949	EAAT	Neurological Disease
GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC₅₀ of 0.26 nM .

HY-W016445

D-Glucamine, 98% 1-Amino-1-deoxy-D-glucitol, 98%	Biochemical Assay Reagents	Others
D-Glucamine, 98% (1-Amino-1-deoxy-D-glucitol, 98%) is an amino sugar derivative that serves as an excipient in pharmaceutical formulations. D-Glucamine, 98% also acts as a substrate for studies investigating sugar transporter pathways

HY-N0455R

L-Arginine (Standard)	Reference Standards NO Synthase Endogenous Metabolite	Cardiovascular Disease Cancer
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-B1274

Cinromide 2 Publications Verification trans-3-Bromo-N-ethylcinnamamide	Amino acid Transporter	Neurological Disease Metabolic Disease
Cinromide is an anticonvulsant agent. Cinromide inhibits epithelial neutral amino acid transporter B ⁰AT1 (SLC6A19) with an IC₅₀ of 0.5 μM .

HY-B0952

2-Aminoheptane 1 Publications Verification TuAminoheptane	Adrenergic Receptor	Neurological Disease
2-Aminoheptane (Tuaminoheptane) is a norepinephrine transporter inhibitor. 2-Aminoheptane binds to norepinephrine transporter via ionic and hydrophobic interactions to block norepinephrine uptake. 2-Aminoheptane deactivates ω-TAmla enzyme, reduces recombinant whole cell stability, and acts as an amino group donor substrate for ω-TA and ω-TAmla enzymes. 2-Aminoheptane can be used in research on depression and Alzheimer's disease .

HY-162455

NA-014	EAAT	Neurological Disease
NA-014 is an *excitatory amino* acid transporter 2 (EAAT2**)-selective positive allosteric modulator. NA-014 increases EAAT2-mediated glutamate uptake. NA-014 can be used for the research of epilepsy, neuropathic pain, stroke, drugs of abuse disorders .

HY-N2368A

Arecaidine hydrochloride 1 Publications Verification	GABA Receptor	Neurological Disease
Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H ⁺-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake .

HY-101037S1

Sarcosine-d3 N-Methylglycine-d₃; Sarcosin-d₃	Isotope-Labeled Compounds Endogenous Metabolite GlyT	Cancer
Sarcosine-d₃ is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-168773

(R)-AS-1	EAAT	Neurological Disease
(R)-AS-1 is a selective positive allosteric modulator of the excitatory amino acid transporter 2 (EAAT2), with an EC₅₀ of 11 nM. (R)-AS-1 (at doses of 60 and 90 mg/kg) increases spontaneous locomotor activity in mice. Additionally, it demonstrates anticonvulsant activity in mouse models of seizures induced by maximal electroshock (MES), pentylenetetrazole (PTZ), or electrical stimuli (32 or 44 mA), with ED₅₀s of 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively. (R)-AS-1 can be used in neurological disease research .

HY-139692

EAAT2 activator 1	EAAT	Neurological Disease
EAAT2 activator 1 is the potent activator of *excitatory amino* acid transporter 2 (EAAT2*). EAAT2 is the major glutamate transporter* and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently .

HY-146242

SN05	EAAT ASCT	Cancer
SN05 is a potent amino acid transport (AAT) inhibitor with K_i values of 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM for hASCT1, rASCT2, hASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN05 can be used in the study of cancer .

HY-W677684

Nurr1 agonist 2	Nuclear Hormone Receptor 4A/NR4A	Others
Nurr1 agonist 2 (Compound 7) is a Nurr1 agonist (EC₅₀: 0.07 μM). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand binding domain (LBD) with a K_d value of 0.14 μM. Nurr1 agonist 2 increases the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2) mRNA expression .

HY-162864

JX237	Amino acid Transporter	Metabolic Disease
JX237 is an inhibitor of the epithelial neutral amino acid transporter B ⁰AT1 (SLC6A19) with an IC₅₀ value of 31 nM. SLC6A19 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B ⁰AT1, JX237 can be used for the study of disorders of amino acid metabolism .

HY-N2368B

Arecaidine hydrobromide 1 Publications Verification	GABA Receptor	Neurological Disease
Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H ⁺-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake .

HY-101037R

Sarcosine (Standard) N-Methylglycine (Standard); Sarcosin (Standard)	Reference Standards Endogenous Metabolite GlyT	Cancer
Sarcosine (Standard) is the analytical standard of Sarcosine. This product is intended for research and analytical applications. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-W327145

Lysylglutamic acid	Endogenous Metabolite	Infection
Lysylglutamic acid is a dipeptide formed by combining two amino acids, Lysine (Lys) and Glutamic acid (Glu). The K_i value of the membrane transporter PEPT1 was 1.3 mM .

HY-101037S

Sarcosine-15N N-Methylglycine-¹⁵N; Sarcosin-¹⁵N	Endogenous Metabolite GlyT	Cancer
Sarcosine- ¹⁵N is the ¹⁵N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-146241

SN40	EAAT ASCT	Cancer
SN40 is a potent amino acid transport (AAT) inhibitor with K_is of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer .

HY-146241B

SN40 hydrochloride	EAAT ASCT	Others
SN40 hydrochloride is a potent amino acid transport (AAT) inhibitor with K_is of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 hydrochloride can be used for researching anticancer .

HY-108540R

BCH (Standard) 2-Amino-2-norbornanecarboxylic acid (Standard); LAT1-IN-1 (Standard)	Apoptosis Reference Standards	Cancer
BCH (Standard) is the analytical standard of BCH. This product is intended for research and analytical applications. BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis .

HY-107522B

DL-TBOA ammonium	EAAT	Neurological Disease
DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for *excitatory amino* acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [ ¹⁴C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA ammonium blocks EAAT4 and EAAT5 in a competitive manner with K_i** values of 4.4 μM and 3.2 μM, respectively .

HY-N0455C

L-Arginine arginine	NO Synthase Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
L-Arginine arginine is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-175296

EAAT2 activator 2	EAAT	Neurological Disease
EAAT2 activator 2 (Compound 4(SF-2)) is a brain-penetrant excitatory amino acid transporter 2 (EAAT2) modulator (K_i=28.7 nM). EAAT2 activator 2 enhances EAAT2-mediated glutamate uptake, improving synaptic glutamate clearance. EAAT2 activator 2 is promising for research of neurodegenerative diseases (e.g., ALS, Alzheimer’s disease) .

HY-W748519

Sarcosine-13C3 N-Methylglycine-¹³C₃; Sarcosin-¹³C₃	Isotope-Labeled Compounds GlyT Endogenous Metabolite	Cancer
Sarcosine- ¹³C₃ (N-Methylglycine- ¹³C₃; Sarcosin- ¹³C₃) is the ¹³C-labeled Sarcosine (HY-101037). Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-120139A

(R)-KMH-233	ASCT	Cancer
(R)-KMH-233 is the isomer of KMH-233 (HY-120139), and can be used as an experimental control. KMH-233, a potent, reversible and selective *l-type amino* acid transporter 1 (LAT1)** inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) .

HY-164401

QBS10072S	DNA Alkylator/Crosslinker Apoptosis	Cancer
QBS10072S is a LAT1-selective substrate with blood-brain barrier permeability that inhibits tumor growth. QBS10072S enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces interstrand DNA cross-linking and cell apoptosis, and reduces leptomeningeal dissemination. QBS10072S can be used in studies related to glioblastoma multiforme, diffuse intrinsic pontine glioma, triple-negative breast cancer brain metastases, and aggressive T-cell lymphoma .

HY-N2368AR

Arecaidine hydrochloride (Standard)	Reference Standards GABA Receptor	Neurological Disease
Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake .

HY-107525

(±)-HIP-A	EAAT	Neurological Disease
(±)-HIP-A is a non-competitive excitatory amino acid transporter (EAAT) blocker that effectively blocks Glu uptake (IC₅₀=17-18 μM). (±)-HIP-A is also a lead compound against ischemia-induced neuronal degeneration. (±)-HIP-A can be used in the study of neurological diseases .

HY-107524

(±)-HIP-B	EAAT	Neurological Disease
(±)-HIP-B is a non-competitive excitatory amino acid transporter (EAAT) blocker that effectively blocks Glu uptake (IC₅₀=17-18 μM). (±)-HIP-B is also a lead compound against ischemia-induced neuronal degeneration. (±)-HIP-B can be used in the study of neurological diseases .

HY-161062

TAOA AM Ester trimethyl lock	EAAT	Neurological Disease
TAOA AM Ester trimethyl lock is a high-affinity fluorescent prodrug-like inhibitor of the excitatory amino acid transporter (EAAT). It can penetrate the cell membrane and be activated by hydrolysis by endogenous cell esterases to form active EAAT inhibitors. TAOA AM Ester trimethyl lock can be used to study neurodegeneration and neuronal cell death .

HY-W740245

Arecaidine-d5 hydrobromide	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Arecaidine-d₅ hydrobromide is the deuterium labeled Arecaidine hydrobromide (HY-N2368B). Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake .

HY-N0455AR

L-Arginine hydrochloride (Standard) (S)-(+)-Arginine hydrochloride (Standard)	Reference Standards NO Synthase Endogenous Metabolite	Cancer
L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-W267524

H-Phe(3-CF3)-OH	Drug Derivative	Cancer
H-Phe (3-CF3)-OH is a phenylalanine derivative targeting the L-type amino acid transporter 1 (LAT1, SLC7A5) as its core target, and it belongs to LAT1 substrates. H-Phe (3-CF3)-OH can be used for prodrug scaffold development and research related to multiple solid tumors .

HY-W246010

α,α-DiBn-DL-Gly Dibenzylglycine	Amino acid Transporter	Others
α,α-DiBn-DL-Gly (Dibenzylglycine) is an achiral α-substituted phenylalanine derivative, non-substrate weak inhibitor of LAT1 (L-type amino acid transporter 1). α,α-DiBn-DL-Gly does not stimulate efflux of-Gabapentin from preloaded HEK-hLAT1 cells. α,α-DiBn-DL-Gly shows minimal inhibition of-Gabapentin (HY-A0057) uptake into HEK-hLAT1 cells .

HY-179689

SLC6A19-IN-5	Amino acid Transporter	Metabolic Disease
SLC6A19-IN-5 (Example 25) is a SLC6A19 inhibitor with an IC₅₀ of 11 nM. SLC6A19-IN-5 can be used for research on diseases related to abnormal amino acid metabolism, amino acid transport, and/or amino acid levels .

HY-183588

HCM-01	EAAT Reactive Oxygen Species (ROS)	Neurological Disease
HCM-01 is an *Excitatory amino* acid transporter 2 (EAAT2**) activator with oral effectiveness and blood-brain barrier penetration.HCM-01 binds to the allosteric site of EAAT2, increases EAAT2 expression in astrocytes, enhances glutamate-handling capacity, and modulates glutamate homeostasis.HCM-01 acts as an antioxidant, improves oxidative/antioxidative balance and increases total antioxidant capacity. HCM-01 can be used for the research of Alzheimer's disease .

HY-W772441

H-Phe(3-tBu)-OH hydrochloride	Amino Acid Derivatives	Others
H-Phe(3-tBu)-OH hydrochloride is an amino acid derivative commonly used in biochemical research and organic synthesis .

Cat. No.	Product Name

HY-L208

Bile Acids Library

61 compounds

Bile acids are a class of amphiphilic molecules derived from the metabolic breakdown of cholesterol, primarily synthesized in the liver, and play a crucial role in the intestines. Based on their structural characteristics, bile acids are mainly divided into two categories: free bile acids (including Cholic acid, Deoxycholic acid, Chenodeoxycholic acid) and conjugated bile acids (including Glycocholic acid, Glycochenodeoxycholic acid, Taurocholic acid, etc.). Bile acids play a significant role in the pathophysiological research of liver and gastrointestinal diseases and are closely associated with the occurrence of metabolic diseases such as obesity, type II diabetes, non-alcoholic fatty liver disease, and atherosclerosis. Bile acids maintain metabolic balance within the body by regulating sugar metabolism, lipid metabolism, and amino acid metabolism, and they influence the activity of metabolism-related enzymes and transporters. In addition, Bile acids can also be used to construct a bile acid metabolism research platform, which helps to delve into the metabolic pathways and dynamic changes of bile acids in living organisms and aids in identifying new biomarkers for certain diseases.

MCE included 61 bile acids, including Cholic acid, Deoxycholic acid, Glycocholic acid, etc., which are effective tools for the study of liver and gallbladder diseases.

HY-L083

Anti-Cancer Metabolism Compound Library

3,552 compounds

Mutations in oncogenes and tumor suppressor genes can modify multiple signaling pathways and in turn cell metabolism, which facilitates tumorigenesis. The paramount hallmark of tumor metabolism is “aerobic glycolysis” or the Warburg effect, coined by Otto Warburg in 1926, in which cancer cells produce most of energy from glycolysis pathway regardless of whether in aerobic or anaerobic condition. Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside. The increased uptake of glucose is facilitated by the overexpression of several isoforms of membrane glucose transporters (GLUTs). Likewise, the metabolic pathways of glutamine, amino acid and fat metabolism are also altered. Recent trends in anti-cancer drug discovery suggests that targeting the altered metabolic pathways of cancer cells result in energy crisis inside the cancer cells and can selectively inhibit cancer cell proliferation by delaying or suppressing tumor growth.

MCE provides a unique collection of 3,552 compounds which cover various tumor metabolism-related signaling pathways. These compounds can be used for anti-cancer metabolism targets identification, validation as well anti-cancer drug discovery.

Cat. No.	Product Name	Type

HY-B1102

Evans Blue

25+ Cited Publications

Direct Blue 53; T-1824; C.I. 23860

Biochemical Assay Reagents

Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability .

HY-W087830

L-p-Boronophenylalanine

L-BPA

Biochemical Assay Reagents

L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (L_AT1 and L_AT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma .

HY-Y1147

Diethyl maleate

1 Publications Verification

Maleic acid diethyl ester

Biochemical Assay Reagents

Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

HY-W016445

D-Glucamine, 98% 1-Amino-1-deoxy-D-glucitol, 98%	Biochemical Assay Reagents
D-Glucamine, 98% (1-Amino-1-deoxy-D-glucitol, 98%) is an amino sugar derivative that serves as an excipient in pharmaceutical formulations. D-Glucamine, 98% also acts as a substrate for studies investigating sugar transporter pathways

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0455

L-Arginine 20+ Cited Publications	Cardiovascular Disease Structural Classification Classification of Application Fields Amino acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite NO Synthase
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455A

L-Arginine hydrochloride Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine hydrochloride	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	NO Synthase Endogenous Metabolite
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-101037

Sarcosine 3 Publications Verification N-Methylglycine; Sarcosin	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Disease markers Endocrine diseases Amino acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite GlyT
Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive *glycine transporter* type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor** co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-N0455R

L-Arginine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Amino acids Endogenous metabolite Source Classification	Reference Standards NO Synthase Endogenous Metabolite
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N2368A

Arecaidine hydrochloride 1 Publications Verification	Alkaloids Areca catechu L. Pyridine Alkaloids Palmae Plants Source Classification	GABA Receptor
Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H ⁺-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake .

HY-101037R

Sarcosine (Standard) N-Methylglycine (Standard); Sarcosin (Standard)	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Disease markers Endocrine diseases Amino acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite GlyT
Sarcosine (Standard) is the analytical standard of Sarcosine. This product is intended for research and analytical applications. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-N2368AR

Arecaidine hydrochloride (Standard)	Alkaloids Structural Classification Areca catechu L. Pyridine Alkaloids Palmae Plants Source Classification	Reference Standards GABA Receptor
Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake .

HY-N0455AR

L-Arginine hydrochloride (Standard) (S)-(+)-Arginine hydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards NO Synthase Endogenous Metabolite
L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

Species:	Human (6)
Tag:	His (5) GST (1) MBP (3) Flag (3)
Source:	HEK293 (2) E. coli Cell-free (1) Sf9 insect cells (1) E. coli (2)

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HY-P702036

	SLC38A1 Protein, Human (sf9, His, MBP, FLAG) SLC38A1; Sodium-coupled neutral Amino acid Transporter 1; Amino acid Transporter A1; N-system Amino acid Transporter 2; Solute carrier family 38 member 1; System A Amino acid Transporter 1; System N Amino acid Transporter 1	Human	Sf9 insect cells
	The SLC38A1 protein acts as an symporter, facilitating the pH-dependent cotransport of short-chain neutral amino acids and sodium ions across cell membranes. Crucially, it mediates astrocyte-derived glutamine transport to GABAergic interneurons, contributing to de novo GABA synthesis. SLC38A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC38A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

HY-P703256

	SLC7A7-SLC3A2 Protein, Human (HEK293, His, MBP, Flag) Y+L Amino acid Transporter 1; Monocyte Amino acid permease 2; MOP-2; Solute carrier family 7 member 7; y(+)L-type Amino acid Transporter 1; Y+LAT1; y+LAT-1; SLC7A7; Homo sapiens; Human; MOP-2	Human	HEK293

HY-P702444

	SLC7A11 Protein, Human (Cell-Free, His) 1 Publications Verification Cystine/glutamate Transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT	Human	E. coli Cell-free
	The SLC7A11 protein forms a heterodimer with SLC3A2 and acts as an antiporter to exchange extracellular L-cystine for intracellular L-glutamate across the plasma membrane. This sodium-independent electroneutral transport, with a 1:1 stoichiometry, relies on high intracellular levels of L-glutamate and intracellular reduction of L-cystine. SLC7A11 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC7A11 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P704158

	SLC1A5/ASCT2 Protein, Human (HEK293, His, TrxA) Neutral Amino acid Transporter B(0); SLC1A5; ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral Amino acid Transporter type 2; Solute carrier family 1 member5; ASCT2; M7V1; RDR; RDRC; AAAT; ASCT2M7VS1; M7V1ATBO; R16; RD114; RDRCFLJ31068	Human	E. coli
	SLC1A5/ASCT2 Protein, Human (HEK293, His, TrxA) is the recombinant human-derived SLC1A5 protein, expressed by E. coli, with N-His & N-TrxA tag.

HY-P703316

	SLC17A5 Protein, Human (HEK293, His, MBP, Flag) Sialin; H(+)/nitrate coTransporter; H(+)/sialic acid coTransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory Amino acid Transporter; VEAT; SLC17A5; Homo sapiens; Human; AST	Human	HEK293
	SLC17A5 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived SLC17A5, expressed by HEK293 , with His, MBP, Flag labeled tag. ,

HY-P71534

	DDX39B Protein, Human (GST) 0610030D10Rik; 4F2-LC6; 56kDa U2AF65-associated protein; AI428441; ATP-dependent RNA helicase p47; B(0,+)-type Amino acid Transporter 1; BAT1; Bat1a; D17H6S81E; D17H6S81E-1; D6S81E; D6S81Eh; DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; DX39B_HUMAN; EC 3.6.1.-; Glycoprotein-associated Amino acid Transporter b0,+AT1; HLA-B-associated transcript 1 protein; HLA-B-associated transcript 1A; HLA-B-associated transcript-1; MGC127051; MGC19235; MGC38799; nuclear RNA helicase (DEAD family); OTTHUMP00000029229; OTTHUMP00000165889; OTTHUMP00000165890; p47; Solute carrier family 7 member 9; Spliceosome RNA helicase BAT1; Spliceosome RNA helicase DDX39B; U2AF65-associayed protein; 56-KD; UAP56	Human	E. coli
	The DDX39B protein intricately coordinates nuclear mRNA export and is specifically associated with spliced mRNA as a key component of the TREX complex. This coupling of mRNA transcription, processing, and export involves rounds of ATP-dependent hydrolysis, recruiting components such as ALYREF/THOC and CHTOP. DDX39B Protein, Human (GST) is the recombinant human-derived DDX39B protein, expressed by E. coli , with N-GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-101037S1

Sarcosine-d3
Sarcosine-d₃ is the deuterium labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-101037S

Sarcosine-15N
Sarcosine- ¹⁵N is the ¹⁵N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-W748519

Sarcosine-13C3

Sarcosine- ¹³C₃ (N-Methylglycine- ¹³C₃; Sarcosin- ¹³C₃) is the ¹³C-labeled Sarcosine (HY-101037). Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .

HY-W740245

Arecaidine-d5 hydrobromide
Arecaidine-d₅ hydrobromide is the deuterium labeled Arecaidine hydrobromide (HY-N2368B). Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake .

Host:	Mouse (1) Rabbit (10)
Reactivity:	Human (9) Rat (6) Mouse (6) human (1)
Application:	IHC-P (9) ICC/IF (4) IF-Tissue (1) IP (4) IHC-F (1) WB (6) ELISA (3)
Isotype:	IgG (10) IgG2a (1)
Conjugation:	Non-conjugated (11)
Clonality:	Monoclonal (8) Recombinant (6)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82737

	EAAT2 Antibody (YA2482) Excitatory Amino acid Transporter 2; Glutamate/aspartate Transporter II; Sodium-dependent glutamate/aspartate Transporter 2; Solute carrier family 1 member 2	WB, IP	Human, Mouse, Rat
	EAAT2 Antibody (YA2482) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EAAT2.

HY-P82620

	EAAT3 Antibody (YA2365) SLC1A1; EAAC1; EAAT3; Excitatory Amino acid Transporter 3; Excitatory Amino-acid carrier 1; Neuronal and epithelial glutamate Transporter; Sodium-dependent glutamate/aspartate Transporter 3; Solute carrier family 1 member 1	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	EAAT3 Antibody (YA2365) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EAAT3.

HY-P82734

	EAAT1 Antibody (YA2479) SLC1A3; EAAT1; GLAST; GLAST1; Excitatory Amino acid Transporter 1; Sodium-dependent glutamate/aspartate Transporter 1; GLAST-1; Solute carrier family 1 member 3	WB, IHC-P	Human, Mouse, Rat
	EAAT1 Antibody (YA2479) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EAAT1.

HY-P86606

	EAAT1 Antibody (YA6298) SLC1A3; EAAT1; GLAST; GLAST1; Excitatory Amino acid Transporter 1; Sodium-dependent glutamate/aspartate Transporter 1; GLAST-1; Solute carrier family 1 member 3	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	EAAT1 Antibody (YA6298) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EAAT1.

HY-P87075

	SLC32A1/VGAT Antibody (YA6768) bA122O1.1 antibody; GABA and glycine Transporter antibody; hVIAAT antibody; SLC32A 1 antibody; Slc32a1 antibody; solute carrier family 32 (GABA vesicular Transporter) member 1 antibody; Solute carrier family 32 member 1 antibody; Vesicular GABA Amino acid Transporter antibody; Vesicular GABA Transporter antibody; Vesicular inhibitory Amino acid Transporter antibody; bA122O1.1 antibody; GABA and glycine Transporter antibody; hVIAAT antibody; SLC32A 1 antibody; Slc32a1 antibody; solute carrier family 32 (GABA vesicular Transporter) member 1 antibody; Solute carrier family 32 member 1 antibody; Vesicular GABA Amino acid Transporter antibody; Vesicular GABA Transporter antibody; Vesicular inhibitory Amino acid Transporter antibody; VGAT antibody; VIAAT antibody; VIAAT_HUMAN antibody;	IHC-F, IHC-P	Mouse, Rat
	SLC32A1/VGAT Antibody (YA6768) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC32A1/VGAT.

HY-P810077

	SNAT4 Antibody (YA9421) Amino acid Transporter A3, ATA3, NAT3, PAAT, SLC38A4, SNAT4	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	SNAT4 Antibody (YA9421) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SNAT4.

HY-P81435

	SLC1A5/ASCT2 Antibody (YA1180) SLC1A5 ; ASCT2; M7V1, RDR, RDRC; Neutral Amino acid Transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral Amino acid Transporter type 2; Solute carrier family 1 member 5	IHC-P	Human
	SLC1A5/ASCT2 Antibody (YA1180) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC1A5/ASCT2.

HY-P81435A

	SLC1A5/ASCT2 Antibody (YA1180)(PBS only) SLC1A5 ; ASCT2; M7V1, RDR, RDRC; Neutral Amino acid Transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral Amino acid Transporter type 2; Solute carrier family 1 member 5	IHC-P	Human
	SLC1A5/ASCT2 Antibody (YA1180) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC1A5/ASCT2.

HY-P86499

	xCT Antibody (YA6191) Cystine/glutamate Transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	xCT Antibody (YA6191) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to xCT.

HY-P81448

	SLC7A5/LAT1 Antibody (YA1193) SLC7A5; CD98LC, LAT1; MPE16; Large neutral Amino acids Transporter small subunit 1; 4F2 light chain (4F2 LC; 4F2LC); CD98 light chain; Integral membrane protein E16; Solute carrier family 7 member 5	IHC-P	Human
	SLC7A5/LAT1 Antibody (YA1193) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC7A5/LAT1.

HY-P81448A

	SLC7A5/LAT1 Antibody (YA1193)(PBS only) SLC7A5; CD98LC, LAT1; MPE16; Large neutral Amino acids Transporter small subunit 1; 4F2 light chain (4F2 LC; 4F2LC); CD98 light chain; Integral membrane protein E16; Solute carrier family 7 member 5	IHC-P	Human
	SLC7A5/LAT1 Antibody (YA1193) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC7A5/LAT1.

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Cat. No.	Product Name		Classification

HY-N0455

L-Arginine 20+ Cited Publications		Solubilizing Agents
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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