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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
86 Results for "
C5 protein
" in MedChemExpress (MCE) Product Catalog:
Products (86)
86 Results for "C5 protein" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-P7695
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing protein 4; Complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; Complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:
Mouse
Source:
E. coli
1
1
1 Cited Publications
Target:
Research Areas:
Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC). Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
1
1 Cited Publications
Cat. No.: HY-P700862
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing protein 4; Complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; Complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P7864
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C5; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing protein 4; Complement C5; C5a Anaphylatoxin; CPAMD4; Prepro-C5; Complement Component 5; Anaphylatoxin C5a Analog; C5a; ECLZB; C5b; C5D
Species:
Human
Source:
E. coli
1
1
1 Cited Publications
Cat. No.: HY-P72137
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CFB; Complement Factor B Preproprotein; Prev. BFD; Glycine-Rich Beta Glycoprotein; Prev. BF; C3 Proaccelerator; Properdin Factor B; C3 Proactivator; C3/C5 Convertase; ARMD14; H2-Bf; AHUS4; B-Factor, Properdin; FBI12; Properdin B; CFAB; PBF2; CFBD; GBG; FB
Species:
Mouse
Source:
E. coli
Cat. No.: HY-NP004
Synonyms: CVF
Cat. No.: HY-D1612
CAS No.: 133867-53-5
Cat. No.: HY-Y0252S
CAS No.: 201740-83-2
Cat. No.: HY-P99365
CAS No.: 1803171-55-2
Synonyms: ALXN1210
Target:
Research Areas:
Cat. No.: HY-145720
CAS No.: 1639264-46-2
Synonyms: ALN-CC5
Research Areas:
Cemdisiran (ALN-CC5) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .
Cat. No.: HY-B0228S1
CAS No.: 159496-13-6
Synonyms: Adenine riboside-13C5; D-Adenosine-13C5
Research Areas:
Lenalidomide-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 hydrochloride can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2 .
Cat. No.: HY-P99638
CAS No.: 2456407-94-4
Synonyms: ALXN-1720
Target:
Research Areas:
Cat. No.: HY-Y0252S4
CAS No.: 202407-23-6
Cat. No.: HY-145720A
Purity: 96.02%
Synonyms: ALN-CC5 sodium
Research Areas:
Cemdisiran sodium (ALN-CC5 sodium) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran sodium targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran sodium exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran sodium achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran sodium can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases .
Cat. No.: HY-160241
CAS No.: 2338824-30-7
Research Areas:
Lenalidomide-C5-acid is the Lenalidomide-based E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Lenalidomide-C5-acid can be used to synthesize PROTACs .
Cat. No.: HY-122725
CAS No.: 2093388-45-3
Lenalidomide-C5-NH2 is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2 .
Cat. No.: HY-B1654S
Synonyms: FAD-13C5 ammonium
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
