FAM172A Protein, Human (HEK293, His)
The FAM172A protein has multiple uses in the regulation of alternative splicing, interacting with AGO2 and CHD7 to coordinate RNA processing and chromatin modification. In addition to its role in splicing, FAM172A stabilizes protein-protein interactions at the chromatin-spliceosome interface, revealing multifaceted functions. FAM172A Protein, Human (HEK293, His) is the recombinant human-derived FAM172A protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The FAM172A protein has multiple uses in the regulation of alternative splicing, interacting with AGO2 and CHD7 to coordinate RNA processing and chromatin modification. In addition to its role in splicing, FAM172A stabilizes protein-protein interactions at the chromatin-spliceosome interface, revealing multifaceted functions. FAM172A Protein, Human (HEK293, His) is the recombinant human-derived FAM172A protein, expressed by HEK293 , with C-6*His labeled tag.
Background
FAM172A, a versatile protein, emerges as a crucial player in the intricate landscape of alternative splicing regulation. Its interaction with AGO2 and CHD7 suggests a pivotal role in orchestrating the dynamic interplay between RNA processing and chromatin modifications. Beyond its regulatory role in alternative splicing, FAM172A appears to contribute to the stabilization of protein-protein interactions at the chromatin-spliceosome interface, underscoring its multifaceted functions within cellular processes. Additionally, there are indications suggesting potential hydrolase activity, adding another layer to the diverse functions attributed to FAM172A. Within the cellular milieu, FAM172A forms a complex alongside AGO2 and CHD7, implying collaborative efforts in shaping the intricate landscape of RNA processing and chromatin dynamics.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
Q8WUF8-1 (Q19-L416)
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Molecular Construction
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N-term
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FAM172A (Q19-L416)
Accession # Q8WUF8-1 -
6*His
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C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
ARB2A; Cotranscriptional Regulator ARB2A; Prev. C5orf21; DKFZP564D172; Prev. FAM172A; Family With Sequence Similarity 172, Member A; Toupee; Chromosome 5 Open Reading Frame 21; Family With Sequence Similarity 172 Member A; CDNA FLJ51952; Cotranscriptional
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AA Sequence
QIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALGEIITKYVYELLEKDCNLKKVSIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPFIKRAVAEGYGVIVLNPNENYIEVEKPKIHVQSSSDSSDEPAEKRERKDKVSKETKKRRDFYEKYRNPQREKEMMQLYIRENGSPEEHAIYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWKSFPSIFKFFTEASEAKTSSLKPAVTRRSHRIKHEEL
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Predicted Molecular Mass
47 kDa
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Molecular Weight
Approximately 40-60 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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