2. Immunology/Inflammation
  3. CD3
  4. Talquetamab

Talquetamab  (Synonyms: JNJ-64407564)

Cat. No.: HY-P99394 Purity: 98.52%
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Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity.

For research use only. We do not sell to patients.

Talquetamab Chemical Structure

Talquetamab Chemical Structure

CAS No. : 2226212-40-2

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Description

Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity[1][2].

In Vitro

Talquetamab (0.00128-4.0 μg/mL, 48 h) effectively induces multiple myeloma cell lysis and leads to a significant increase in the proportion of activated CD4+ and CD8+ T cells, as well as to a dose-dependent increase in the levels of granzyme B and inflammatory cytokines such as IL-6, IL-8 and TNF-α[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Talquetamab Related Antibodies
In Vivo

Talquetamab (JNJ-64407564) (0.1-50 µg, s.c. or i.v.) has significant antitumor activity in H929 and MM mouse models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSG mice with H929 cells[2]
Dosage: 0.1-10 µg (0.005 mg/kg)
Administration: Subcutaneous injection; on days 0, 3, 5, 7, and 10
Result: Completely blocked tumor formation at 1 μg and 10 μg doses.
Animal Model: Female NSG mice with human MM cells[2]
Dosage: 0.1-50 µg (0.005 mg/kg)
Administration: Intravenous injection; on days 15, 18, 22, 24, 29, 32, and 36
Result: Significantly inhibited tumor growth by 65% at the dose of 1μg and showed significant anti-tumor activity at 10 and 50 μg with complete tumor regression.
Clinical Trial
Molecular Weight

146000.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Talquetamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.52%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Talquetamab2226212-40-2JNJ-64407564JNJ64407564JNJ 64407564CD3Cluster of differentiation 3GPRC5DantitumorAMLMM cellInhibitorinhibitorinhibit

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