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Cat. No.: HY-P99394

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Biologically Validated

Talquetamab

(Synonyms: JNJ-64407564)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2226212-40-2
Molecular Weight:144.58 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Talquetamab Chemical Structure

CAS No.: 2226212-40-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Ig(G4-kappa_G4-lambda2)

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

GPRC5D & CD3E

In Vitro

Talquetamab (0.00128-4.0 μg/mL, 48 h) effectively induces multiple myeloma cell lysis and leads to a significant increase in the proportion of activated CD⁴⁺ and CD⁸⁺ T cells, as well as to a dose-dependent increase in the levels of granzyme B and inflammatory cytokines such as IL-6, IL-8 and TNF-α^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Talquetamab (JNJ-64407564) (0.1-50 µg, s.c. or i.v.) has significant antitumor activity in H929 and MM mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female NSG mice with H929 cells^[2]
Dosage:

0.1-10 µg (0.005 mg/kg)
Administration:

Subcutaneous injection; on days 0, 3, 5, 7, and 10
Result:

Completely blocked tumor formation at 1 μg and 10 μg doses.

Animal Model:

Female NSG mice with human MM cells^[2]
Dosage:

0.1-50 µg (0.005 mg/kg)
Administration:

Intravenous injection; on days 15, 18, 22, 24, 29, 32, and 36
Result:

Significantly inhibited tumor growth by 65% at the dose of 1μg and showed significant anti-tumor activity at 10 and 50 μg with complete tumor regression.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

55507 [NCBI] & 916 [NCBI]

Accession

Q9NZD1 & P07766

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human Ig(G4-kappa_G4-lambda2)

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Flow cytometry analysis of GPRC5D overexpression CHOK1 cells labelling GPRC5D with Talquetamab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
Flow cytometry analysis of Jurkat cells labelling CD3 with Talquetamab at 20nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

Chemical Information

CAS No. 2226212-40-2
Appearance Liquid
Molecular Weight 144.58 kDa
Color Colorless to light yellow
SMILES

[Talquetamab]
Synonyms

JNJ-64407564
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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MAbs

Optimizing human FcRn mouse models to improve pharmacokinetic evaluation of antibody drug candidates. [Abstract]

2026 Dec 31;18(1):2649990. PMID: 41878863

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Christie P M Verkleij, et al. Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2196-2215. [Content Brief]

[2]. Kodandaram Pillarisetti, et al. A T-cell-redirecting bispecific G-protein-coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma. Blood. 2020 Apr 9;135(15):1232-1243. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Publications (1)
Purity & Documentation
References

1/16

Human Ig(G4-kappa_G4-lambda2)
1/16

Flow cytometry analysis of GPRC5D overexpression CHOK1 cells labelling GPRC5D with Talquetamab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
1/16

Flow cytometry analysis of Jurkat cells labelling CD3 with Talquetamab at 20nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
1/16

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Talquetamab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Publications Citing Use of MedChemExpress (MCE) Talquetamab