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Results for "

Leishmania donovani

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) Aminoacyl-tRNA Synthetase (1) Antibiotic (1) Apoptosis (4) Autophagy (1) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (3) Calcium Channel (1) Cytochrome P450 (2) Drug Derivative (2) Drug Intermediate (1) Mitochondrial Metabolism (2) NO Synthase (1) Opioid Receptor (1) P-glycoprotein (2) p38 MAPK (1) Parasite (41) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (ROS) (3) Reference Standards (2) Succinate Dehydrogenase (1) Toll-like Receptor (TLR) (1) Topoisomerase (2) α-synuclein (1)
By Research Areas:	Cancer (6) Infection (44) Inflammation/Immunology (4) Neurological Disease (2)
Oligonucleotides:	CpG ODNs (1) Phospholipids (1)

Inhibitors & Agonists

Peptides

Natural
Products

Oligonucleotides

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-150743

ODN 2395	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
ODN 2395 is a C class oligodeoxynucleotide and can be used as vaccine adjuvant. ODN 2395 is also a TLR9 agonist. ODN 2395 can be used in the research of immunological vaccines. Sequence: 5'-tcgtcgttttcggcgc:gcgccg-3' (Note: The bases are phosphorothioate; ODN 2395 contains the partial palindromic sequence cggcgc:gcgccg) .

HY-16565

10-Deacetylbaccatin III	Biochemical Assay Reagents Drug Intermediate Parasite	Infection
10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata). 10-Deacetylbaccatin III exhibits antileishmanial activity .

HY-108610A

Edelfosine 1 Publications Verification ET-18-OCH3	Apoptosis Parasite Bcl-2 Family Cytochrome P450	Infection Inflammation/Immunology Cancer
Edelfosine (ET-18-OCH3) is an orally active lipid raft modulator and apoptosis inducer that alters membrane fluidity and preferentially inserts into tumor cell membranes. Edelfosine recruits death receptor ligands (FasL/CD95L, TRAIL) and Bid to lipid rafts to form death-inducing signaling complexes, thereby initiating mitochondria-dependent apoptosis and inducing cytochrome c release. Edelfosine also exerts anti-inflammatory effects, promotes L-Selectin shedding, and causes no gastrointestinal or organ toxicity. In addition, Edelfosine inhibits nucleic acid and protein synthesis in Leishmania donovani and exhibits antiproliferative activity. Edelfosine can be used in research on multiple myeloma, inflammatory bowel diseases (such as ulcerative colitis and Crohn's disease), and visceral leishmaniasis .

HY-W016813

trans-Aconitic acid	Parasite	Infection
trans-Aconitic acid is an orally active aconitase inhibitor that non-competitively inhibits the conversion of citric acid to cis-aconitic acid and competitively inhibits the conversion of cis-aconitic acid to isocitric acid. trans-Aconitic acid inhibits the growth of Leishmania donovani promastigotes, the transformation of Leishmania donovani amastigotes to promastigotes, and the in vitro proliferation of Leishmania donovani amastigotes within macrophages in vitro. trans-Aconitic acid can be used in research related to visceral leishmaniasis (kala-azar) .

HY-101011

Naloxonazine dihydrochloride	Opioid Receptor	Infection Neurological Disease
Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC₅₀ of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .

HY-N6015

Bacopasaponin C	Parasite P-glycoprotein	Infection Cancer
Bacopasaponin C is an orally active natural glycoside. Bacopasaponin C can be isolated from Bacopa monniera. Bacopasaponin C inhibits Verapamil (HY-14275)-stimulated P-gp ATPase activity with an IC₅₀ of 57.83 μg/mL. Bacopasaponin C has antitumor activity against sarcomas. Bacopasaponin C has antiparasitic activity against Leishmania donovani .

HY-N0413

Hupehenine	α-synuclein Reactive Oxygen Species (ROS) Apoptosis Autophagy Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders .

HY-155520

Antileishmanial agent-19	Parasite	Infection
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC₅₀ of 3.39 μM for L. donovani* promastigotes. Antileishmanial agent-19 inhibits Leishmania* prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani* promastigotes*. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals .

HY-134467

Phylloflavan	Parasite NO Synthase	Infection
Phylloflavan is an antileishmanial (Antileishmanial) agent with an EC₅₀ of 3.2 nM against intracellular amastigotes of Leishmania donovani. Phylloflavan is isolated from Phyllocldus plants. Phylloflavan induces moderate levels of NO release. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblasts (38 U/mL) .

HY-W014120

Thianthrene	Biochemical Assay Reagents Parasite	Infection
Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1). Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC₅₀ = 23 μM). Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo .

HY-162066

DNDI-6174	Parasite	Infection
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis .

HY-W973644

LY-266500	Mitochondrial Metabolism Parasite	Infection
LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei (IC₅₀ =0.6 μM) and Leishmania donovani (IC₅₀ =2.86 μM). LY-266500 can be used for research on parasitic infections .

HY-130993

Isatropolone A	Parasite	Infection
Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against **Leishmania donovani with an IC₅₀** of 0.5 μM .

HY-149093

Antileishmanial agent-14	Parasite	Infection
Antileishmanial agent-14 is a sulfuretin analog with potential activity against the parasite Leishmania donovani promastigotes (IC₅₀=4.1 μM). Antileishmanial agent-14 also inhibits infection by L. donovani* amastigotes* (IC₅₀=11.1 μM) .

HY-147535

Antileishmanial agent-7	Parasite	Infection
Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC₅₀ values of 6.89 and 259 μM, respectively .

HY-163457

Antileishmanial agent-27	Aminoacyl-tRNA Synthetase Parasite	Infection
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC₅₀ values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .

HY-147534

Antileishmanial agent-6	Parasite	Infection
Antileishmanial agent-6 (compound 8m) is a potent antileishmanial agent. Antileishmanial agent-6 shows antileishmanial and cytotoxic activity against Leishmania donovani and L-6, with IC₅₀ values of 0.54 and 10.2 μM, respectively .

HY-161325

Antileishmanial agent-26	Parasite	Infection
Antileishmanial agent-26 (Compound 69) is a guanidine-containing compound with anti-Leishmania donovani activity. Its IC₅₀ value against Leishmania donovani is 5.67 μM, and its CC₅₀ value against THP-1 is 3.79 μM. Antileishmanial agent-26 can be used in the research of tropical diseases .

HY-147537

Antileishmanial agent-9	Parasite	Infection
Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC₅₀ = 40.1 μM) .

HY-162833

Antileishmanial agent-30	Parasite	Infection
Antileishmanial agent-30 (compound 17k) is a potent inhibitor of leishmania, with the IC₅₀, CC₅₀, and SI of 0.2 μM, >100 μM and >500 for L. donovani .

HY-147536

Antileishmanial agent-8	Parasite	Infection
Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC₅₀=73.9 μM) .

HY-N2894

Piperolactam A	Parasite	Infection
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani .

HY-170963

LASSBio-1985	Parasite	Infection
LASSBio-1985 is an NHLd inhibitor (nucleoside hydrolase from Leishmania donovani), with a Ki of 79 μM and an IC₅₀ of 84.6 μM. LASSBio-1985 exhibits selective toxicity against Leishmania parasites, with no toxicity to mammalian cells, making it a promising candidate for research in the field of anti-infective therapies .

HY-W014120R

Thianthrene (Standard)	Biochemical Assay Reagents Reference Standards Parasite	Infection
Thianthrene (Standard) is the analytical standard of Thianthrene. This product is intended for research and analytical applications. Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1). Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC₅₀ = 23 μM). Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo .

HY-N10547

6-O-Methylcatalpol	Parasite	Infection
6-O-Methylcatalpol can be isolated from the roots of Scrophularia ningpoensis. 6-O-Methylcatalpol has anti-protozoal activity against Trypanosoma b. rhodesiense and Leishmania donovani (IC₅₀: 32.5 and 8.3 μg/mL) .

HY-175305

DMU759	Parasite	Infection
DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research .

HY-147766

Antileishmanial agent-10	Parasite	Infection
Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent .

HY-N6015R

Bacopasaponin C (Standard)	Reference Standards Parasite P-glycoprotein	Infection Cancer
Bacopasaponin C (Standard) is the analytical standard of Bacopasaponin C (HY-N6015). This product is intended for research and analytical applications. Bacopasaponin C is an orally active natural glycoside. Bacopasaponin C can be isolated from Bacopa monniera. Bacopasaponin C inhibits Verapamil (HY-14275)-stimulated P-gp ATPase activity with an IC₅₀ of 57.83 μg/mL. Bacopasaponin C has antitumor activity against sarcomas. Bacopasaponin C has antiparasitic activity against Leishmania donovani .

HY-147765

Anti-Trypanosoma cruzi agent-3	Parasite	Infection
Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .

HY-124210

Formycin B	Antibiotic Parasite	Infection Cancer
Formycin B is an antibiotic, which exhibits antiparasitic activity against Leishmania. Formycin B exhibits toxicity to leukocytes, reversibly decreases neutrophils. Formycin B can be used in research about myeloid leukemia .

HY-N19832

Icariside E3	Topoisomerase Parasite	Infection
Icariside E3 is a Leishmania donovani DNA Topoisomerase IB (LdTOP1LS) inhibitor. Icariside E3 can be used for the research of leishmaniasis .

HY-181145

Antitrypanosomal agent 29	Parasite	Infection
Antitrypanosomal agent 29 is an antileishmanial agent against Leishmania donovani. Antitrypanosomal agent 29 shows no inhibitory activity against Trypanosoma cruzi and exhibits no significant cytotoxicity toward human fibroblast MRC-5 cells. Antitrypanosomal agent 29 can be used in research on leishmaniasis .

HY-N19720

Bractein	Drug Derivative Parasite	Infection
Bractein is a natural aurone flavonoid with potential antioxidant activity. Bractein shows in vitro antileishmanial activity and inhibits promastigotes and intracellular amastigotes of Leishmania donovani. Bractein exhibits no obvious cytotoxicity against mammalian macrophages with an EC₅₀ value > 25.0 μg/mL. Bractein can be used for the research of Leishmania .

HY-179584

Antileishmanial agent-38	Parasite	Infection
Antileishmanial agent-38 (compound 197) is a host-directed small molecule antileishmanial agent exhibiting potent broad-spectrum activity against *Leishmania* spp. Antileishmanial agent-38 inhibits intracellular parasites primarily by targeting the host protein lysozyme, while also displaying direct activity against extracellular L. donovani promastigotes. Antileishmanial agent-38 can be used for leishmaniasis research .

HY-183262

Antileishmanial agent-40	Parasite Reactive Oxygen Species (ROS)	Infection
Antileishmanial agent-40 is an orally active and selective antileishmanial agent. Antileishmanial agent-40 elevates intracellular reactive oxygen species (ROS) levels in Leishmania donovani promastigotes. Antileishmanial agent-40 induces cell cycle arrest at the sub-G₀/G₁ phase in Leishmania donovani promastigotes, indicative of programmed-like parasite death. Antileishmanial agent-40 can be used for the research of leishmaniasis .

HY-185309

Anti-Trypanosoma cruzi agent-9	Topoisomerase Parasite	Infection
Anti-Trypanosoma cruzi agent-9 is a topoisomerase II inhibitor. Anti-Trypanosoma cruzi agent-9 inhibits the growth of Trypanosoma cruzi and Leishmania donovani .

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

HY-183290

Antileishmanial agent-41	Parasite Reactive Oxygen Species (ROS)	Infection
Antileishmanial agent-41 (Compound 20k) is a selective Antileishmanial agent with a IC₅₀ of 1.51 μg/mL against Leishmania donovani. Antileishmanial agent-41 increases ROS levels. Antileishmanial agent-41 can be used for the research of leishmaniasis .

HY-129819

(Rac)-DNDI-8219	Bacterial	Infection
(Rac)-DNDI-8219 is an antituberculosis compound with potent anti-leishmanial activity. (Rac)-DNDI-8219 demonstrated superior efficacy in the Leishmania donovani mouse model. (Rac)-DNDI-8219 showed promising activity in the Leishmania infantum hamster model. (Rac)-DNDI-8219 candidate compound R-6 provided excellent oral efficacy in the same hamster model .

HY-W039443

(S)-4-Thiazolidinecarboxylic acid	Parasite Bacterial	Infection
(S)-4-Thiazolidinecarboxylic acid (L-4-thioproline) is a glutamate 5-kinase inhibitor with an IC₅₀ of 1.8 mM against LdG5K. (S)-4-Thiazolidinecarboxylic acid can be used in the research of leishmaniasis and Escherichia coli infections .

HY-19688

Sitamaquine WR 6026	Parasite Succinate Dehydrogenase Apoptosis Calcium Channel Mitochondrial Metabolism	Infection
Sitamaquine (WR 6026) is an orally active Antileishmanial agent and Succinate dehydrogenase inhibitor. Sitamaquine accumulates in the acidocalcisomes of Leishmania, induces organelle alkalization, and crosses the plasma membrane of Leishmania via temperature- and energy-independent diffusion. Sitamaquine disrupts oxidative phosphorylation in Leishmania, induces mitochondrial depolarization, oxidative stress, elevated intracellular calcium, plasma membrane depolarization, and Apoptosis-like cell death. Sitamaquine can be used in the research of leishmaniasis .

HY-179451

Apoptosis inducer 53	Apoptosis p38 MAPK Parasite	Infection Inflammation/Immunology Cancer
Apoptosis inducer 53 is an apoptosis inducer. Apoptosis inducer 53 can inhibit proliferation of human tumor cell lines (A549, HeLa, SW1573, T-47D, WiDr) with GI₅₀ values of 2.5-9.1 μM. Apoptosis inducer 53 can induce cancer cells apoptosis and reduce colony formation. Apoptosis inducer 53 can activate p38α MAPK signaling and exerts anti-inflammatory effect. Apoptosis inducer 53 also shows anti-Leishmania donovani activity. Apoptosis inducer 53 can be used for the researches of cancer, infection and inflammation .

HY-183362

Antileishmanial agent-42	Parasite Adenosine Kinase	Infection
Antileishmanial agent-42 is an antileishmanial agent. Antileishmanial agent-42 has favorable interactions with key active site residues (e.g., Ser63, Asn66/295/299) of adenosine kinase. Antileishmanial agent-42 exerts activity against promastigote and amastigote forms of L. amazonensis, L. braziliensis, L. infantum, and L. donovani .

HY-W663179

DNDI-VL-2098	Parasite Cytochrome P450	Infection
DNDI-VL-2098 is an orally active antileishmanial agent. DNDI-VL-2098 exhibits high permeability, in vitro metabolic stability, and selective inhibition of CYP2C19 (IC₅₀=0.47 μM). DNDI-VL-2098 does not affect the activities of other major CYP enzymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A4) at concentrations up to 12.5 μM. It shows favorable pharmacokinetic properties in multiple animal models including mice, hamsters, rats and dogs. DNDI-VL-2098 is characterized by moderate to high plasma protein binding and can be used for the research of visceral leishmaniasis .

HY-W701798

(+)-Laudanidine (S)-Tritopin; D-Laudanine	Drug Derivative	Others
(+)-Laudanidine ((S)-Tritopin) is a benzyltetrahydroisoquinoline alkaloid found in Stephania species .

Cat. No.	Nom du produit	Target	Research Area

HY-P2209

Nummularine B Daechuine S27; N-Demethylamphibine H	Parasite Phosphodiesterase (PDE)	Infection
Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca ²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .

Cat. No.	Nom du produit		Classification

HY-150743

ODN 2395		CpG ODNs
ODN 2395 is a C class oligodeoxynucleotide and can be used as vaccine adjuvant. ODN 2395 is also a TLR9 agonist. ODN 2395 can be used in the research of immunological vaccines. Sequence: 5'-tcgtcgttttcggcgc:gcgccg-3' (Note: The bases are phosphorothioate; ODN 2395 contains the partial palindromic sequence cggcgc:gcgccg) .

HY-108610A

Edelfosine 1 Publications Verification ET-18-OCH3		Phospholipids
Edelfosine (ET-18-OCH3) is an orally active lipid raft modulator and apoptosis inducer that alters membrane fluidity and preferentially inserts into tumor cell membranes. Edelfosine recruits death receptor ligands (FasL/CD95L, TRAIL) and Bid to lipid rafts to form death-inducing signaling complexes, thereby initiating mitochondria-dependent apoptosis and inducing cytochrome c release. Edelfosine also exerts anti-inflammatory effects, promotes L-Selectin shedding, and causes no gastrointestinal or organ toxicity. In addition, Edelfosine inhibits nucleic acid and protein synthesis in Leishmania donovani and exhibits antiproliferative activity. Edelfosine can be used in research on multiple myeloma, inflammatory bowel diseases (such as ulcerative colitis and Crohn's disease), and visceral leishmaniasis .

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Leishmania donovani

Inhibitors & Agonists

Peptides

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Oligonucleotides

Natural
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