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Cat. No.: HY-134467

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Phylloflavan

Phylloflavan is an antileishmanial (Antileishmanial) agent with an EC₅₀ of 3.2 nM against intracellular amastigotes of Leishmania donovani. Phylloflavan is isolated from Phyllocldus plants. Phylloflavan induces moderate levels of NO release. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblasts (38 U/mL).

For research use only. We do not sell to patients.

CAS No.: 98570-83-3
Formula: C₂₆H₂₆O₁₀
Molecular Weight:498.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Phylloflavan Chemical Structure

CAS No.: 98570-83-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Leishmania donovani

3.2 nM (EC₅₀)

All Parasite Isoforms :

All NO Synthase Isoforms :

In Vitro

Phylloflavan (50 μg/mL and serial two-fold dilutions; 72 h) potently inhibits intracellular Leishmania donovani amastigote survival in RAW 264.7 cells with an EC₅₀ of 3.2 nM, while lacking cytotoxicity against host cells and activity against extracellular promastigotes^[1].
Phylloflavan (50 μg/mL; 48 h) induces moderate nitric oxide release from RAW 264.7 cells^[1].
Phylloflavan (50 μg/mL; 48 h) induces IFN-like activity in RAW 264.7 cells, resulting in 38 U/mL of cytoprotective activity against EMCV-induced cytopathic effect on L929 fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 98570-83-3
Molecular Weight 498.48
Formula C₂₆H₂₆O₁₀
SMILES

O=C(C[C@@H](O)CCC1=CC(O)=C(O)C=C1)O[C@H]2CC3=C(O)C=C(O)C=C3O[C@@H]2C4=CC(O)=C(O)C=C4
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kolodziej H, et al. Proanthocyanidins and related compounds: antileishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-alpha-release in the murine macrophage-like cell line RAW 264.7. Biol Pharm Bull. 2001;24(9):1016-1021. [Content Brief]

[2]. Foo L Y, et al. Phylloflavan, a characteristic constituent of Phyllocladus species[J]. Phytochemistry, 1985, 24(7): 1495-1498.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Phylloflavan

All Parasite Isoforms

All NO Synthase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Phylloflavan Related Classifications

HY-134467 Related Classifications