Phylloflavan 

Phylloflavan is an antileishmanial (Antileishmanial) agent with an EC₅₀ of 3.2 nM against intracellular amastigotes of Leishmania donovani. Phylloflavan is isolated from Phyllocldus plants. Phylloflavan induces moderate levels of NO release. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblasts (38 U/mL)^[1][2].

Phylloflavan (50 μg/mL and serial two-fold dilutions; 72 h) potently inhibits intracellular Leishmania donovani amastigote survival in RAW 264.7 cells with an EC₅₀ of 3.2 nM, while lacking cytotoxicity against host cells and activity against extracellular promastigotes^[1].
Phylloflavan (50 μg/mL; 48 h) induces moderate nitric oxide release from RAW 264.7 cells^[1].
Phylloflavan (50 μg/mL; 48 h) induces IFN-like activity in RAW 264.7 cells, resulting in 38 U/mL of cytoprotective activity against EMCV-induced cytopathic effect on L929 fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

498.48

C₂₆H₂₆O₁₀

98570-83-3

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• [1]. Kolodziej H, et al. Proanthocyanidins and related compounds: antileishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-alpha-release in the murine macrophage-like cell line RAW 264.7. Biol Pharm Bull. 2001;24(9):1016-1021.  [Content Brief]

  [2]. Foo L Y, et al. Phylloflavan, a characteristic constituent of Phyllocladus species[J]. Phytochemistry, 1985, 24(7): 1495-1498.