Apoptosis inducer 53 

Apoptosis inducer 53 is an apoptosis inducer. Apoptosis inducer 53 can inhibit proliferation of human tumor cell lines (A549, HeLa, SW1573, T-47D, WiDr) with GI₅₀ values of 2.5-9.1 μM. Apoptosis inducer 53 can induce cancer cells apoptosis and reduce colony formation. Apoptosis inducer 53 can activate p38α MAPK signaling and exerts anti-inflammatory effect. Apoptosis inducer 53 also shows anti-Leishmania donovani activity. Apoptosis inducer 53 can be used for the researches of cancer, infection and inflammation^[1].

Apoptosis inducer 53 (Compound 24) (2.5-9.1 μM) inhibits proliferation of human tumor cell lines (A549, HeLa, SW1573, T-47D, WiDr) with GI₅₀ values of 3.7 μM, 2.5 μM, 3.7 μM, 9.1 μM and 4.9 μM respectively^[1].
Apoptosis inducer 53 (25 μM, 20 h) induces typical apoptotic phenotypes in HeLa cells^[1].
Apoptosis inducer 53 (7.5-12.5 μM, 24 h or 0.83-2.5 μM, 7 days) dose-dependently reduces colony formation in HeLa cells^[1].
Apoptosis inducer 53 inhibits the growth of Leishmania donovani amastigotes in THP-1-differentiated macrophages with an IC₅₀ of 2.59 μM^[1].
Apoptosis inducer 53 (10 μM, 24 h) inhibits NLRP3, Caspase-1 and IL-1β production by activating p38α MAPK in LPS (HY-D1056)-stimulated BV.2 microglial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

531.65

C₂₆H₃₉F₂NO₆S

O[C@H]1[C@H](OCC2=CC=C(F)C=C2)[C@@H](F)[C@@H](S(CCCCCCCCCCCC)(=O)=O)N3[C@@H]1COC3=O

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• [1]. Padilla-Pérez MC, et al. Exploring the influence of the glycone space on the therapeutic potential of sp²-iminoglycolipids. Eur J Med Chem. 2026;302(Pt 2):118337.  [Content Brief]