Apoptosis inducer 53
Apoptosis inducer 53 is an apoptosis inducer. Apoptosis inducer 53 can inhibit proliferation of human tumor cell lines (A549, HeLa, SW1573, T-47D, WiDr) with GI50 values of 2.5-9.1 μM. Apoptosis inducer 53 can induce cancer cells apoptosis and reduce colony formation. Apoptosis inducer 53 can activate p38α MAPK signaling and exerts anti-inflammatory effect. Apoptosis inducer 53 also shows anti-Leishmania donovani activity. Apoptosis inducer 53 can be used for the researches of cancer, infection and inflammation.
For research use only. We do not sell to patients.
- Formula: C26H39F2NO6S
- Molecular Weight:531.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Biological Activity
Apoptosis inducer 53 (Compound 24) (2.5-9.1 μM) inhibits proliferation of human tumor cell lines (A549, HeLa, SW1573, T-47D, WiDr) with GI50 values of 3.7 μM, 2.5 μM, 3.7 μM, 9.1 μM and 4.9 μM respectively[1].
Apoptosis inducer 53 (25 μM, 20 h) induces typical apoptotic phenotypes in HeLa cells[1].
Apoptosis inducer 53 (7.5-12.5 μM, 24 h or 0.83-2.5 μM, 7 days) dose-dependently reduces colony formation in HeLa cells[1].
Apoptosis inducer 53 inhibits the growth of Leishmania donovani amastigotes in THP-1-differentiated macrophages with an IC50 of 2.59 μM[1].
Apoptosis inducer 53 (10 μM, 24 h) inhibits NLRP3, Caspase-1 and IL-1β production by activating p38α MAPK in LPS (HY-D1056)-stimulated BV.2 microglial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:25 μM
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Incubation Time:20 h
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Result:Showed cell shrinkage and content fragmentation.
Caused nuclear condensation and fragmentation and showed positive Annexin V staining.
Did not induce ROS production, disrupt mitochondrial membrane potential, or affect cell microtubule structure.
Chemical Information
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Molecular Weight 531.65
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Formula C26H39F2NO6S
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SMILES
O[C@H]1[C@H](OCC2=CC=C(F)C=C2)[C@@H](F)[C@@H](S(CCCCCCCCCCCC)(=O)=O)N3[C@@H]1COC3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 53 Related Classifications
HY-179451 Related Classifications
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