Piperolactam A
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani.
For research use only. We do not sell to patients.
- CAS No.: 112501-42-5
- Formula: C16H11NO3
- Molecular Weight:265.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
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Leishmania |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
1.3 μM
Compound: 17
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Inhibition of LPS-induced BALB/c mouse B cell proliferation
Inhibition of LPS-induced BALB/c mouse B cell proliferation
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[PMID: 17081761] |
| BV-2 | IC50 |
>50 μM
Compound: 25
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Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay
Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess assay
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[PMID: 33822610] |
| HCT-15 | GI50 |
>30 μM
Compound: 7
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Antiproliferative activity against human HCT15 cells by SRB assay
Antiproliferative activity against human HCT15 cells by SRB assay
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[PMID: 19394218] |
| HCT-15 | GI50 |
>30 μM
Compound: 7
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Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay
Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay
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[PMID: 19394218] |
| MES-SA | GI50 |
>30 μM
Compound: 7
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Antiproliferative activity against human MESSA cells by SRB assay
Antiproliferative activity against human MESSA cells by SRB assay
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[PMID: 19394218] |
| MES-SA/Dx5 | GI50 |
26.96 μM
Compound: 7
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Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay
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[PMID: 19394218] |
| T-cell | IC50 |
0.798 μM
Compound: 17
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Inhibition of ConA-induced BALB/c mouse T cell proliferation
Inhibition of ConA-induced BALB/c mouse T cell proliferation
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[PMID: 17081761] |
Piperolactam A shows inhibitory activity against Leishmania donovani wild-type, drug resistant and field isolated axenic amastigote cell lines, with IC50 values of 60 ± 9.6 (wild-type), 121 ± 18 (SSG resistant), 109 ± 15 (PMM resistant), and 87 ± 12 (field isolate), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 112501-42-5
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Molecular Weight 265.26
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Formula C16H11NO3
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SMILES
O=C1NC2=C3C1=CC(OC)=C(O)C3=C4C(C=CC=C4)=C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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