Bacopasaponin C
Based on 1 publication(s) in Google Scholar
Bacopasaponin C is an orally active natural glycoside. Bacopasaponin C can be isolated from Bacopa monniera. Bacopasaponin C inhibits Verapamil (HY-14275)-stimulated P-gp ATPase activity with an IC50 of 57.83 μg/mL. Bacopasaponin C has antitumor activity against sarcomas. Bacopasaponin C has antiparasitic activity against Leishmania donovani.
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- Reinheit: 99.76%
- CAS. Nr.: 178064-13-6
- Formel: C46H74O17
- Molecular Weight:899.07
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Bacopasaponin C
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Biologische Aktivität
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Leishmania |
Bacopasaponin C (25-100 μM) shows no significant inhibitory effect on MDA-MB-231 cell adhesion, migration, or Matrigel invasion[1].
Bacopasaponin C (50-500 μg/mL; 1 h) exhibits no toxicity to mouse peritoneal macrophages, with negligible macrophage mortality compared with untreated controls [2].
Bacopasaponin C inhibits Verapamil (HY-14275)-stimulated P-gp ATPase activity with an IC50 of 57.83 μg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human ileocecal adenocarcinoma cell line HCT-8
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Concentration:
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Incubation Time:
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Result:Showed an IC50 of 58.3 μM (for cytotoxicity).
Bacopasaponin C in free form reduces the splenic parasite burden of Leishmania donovani (strain AG83) in Golden hamsters by 40%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 178064-13-6
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Appearance Solid
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Molecular Weight 899.07
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Formel C46H74O17
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Color White to off-white
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SMILES
C[C@]12[C@@]34[C@@](CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](O[C@@]6([H])[C@@H]([C@H]([C@@H](O)CO6)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)O[C@]8([H])O[C@@H](CO)[C@H](O)[C@H]8O)CC5)C)([H])CC2)C)([H])[C@]9([H])[C@@](OC4)(OC[C@@H](/C=C(C)\C)[C@@]9(O)C)C3
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
From Tradition to Translation: A Critical Appraisal of Bacopa monnieri for Neuroprotection from Preclinical and Clinical Perspectives and Challenges in Utilization. [Abstract]2026 Jun 17;27(12):5488. PMID: 42353204
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (111.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (2.78 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Peng L, et al. Antitumor activities of dammarane triterpene saponins from Bacopa monniera. Phytother Res. 2010 Jun;24(6):864-8. [Content Brief]
[2]. Sinha J, et al. Bacopasaponin C: critical evaluation of anti-leishmanial properties in various delivery modes. Drug Deliv. 2002 Jan-Mar;9(1):55-62. [Content Brief]
[3]. Singh R, et al. In vitro effects of standardized extract of Bacopa monniera and its five individual active constituents on human P-glycoprotein activity. Xenobiotica. 2015;45(8):741-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1123 mL | 5.5613 mL | 11.1226 mL | 27.8065 mL |
| 5 mM | 0.2225 mL | 1.1123 mL | 2.2245 mL | 5.5613 mL | |
| 10 mM | 0.1112 mL | 0.5561 mL | 1.1123 mL | 2.7807 mL | |
| 15 mM | 0.0742 mL | 0.3708 mL | 0.7415 mL | 1.8538 mL | |
| 20 mM | 0.0556 mL | 0.2781 mL | 0.5561 mL | 1.3903 mL | |
| 25 mM | 0.0445 mL | 0.2225 mL | 0.4449 mL | 1.1123 mL | |
| 30 mM | 0.0371 mL | 0.1854 mL | 0.3708 mL | 0.9269 mL | |
| 40 mM | 0.0278 mL | 0.1390 mL | 0.2781 mL | 0.6952 mL | |
| 50 mM | 0.0222 mL | 0.1112 mL | 0.2225 mL | 0.5561 mL | |
| 60 mM | 0.0185 mL | 0.0927 mL | 0.1854 mL | 0.4634 mL | |
| 80 mM | 0.0139 mL | 0.0695 mL | 0.1390 mL | 0.3476 mL | |
| 100 mM | 0.0111 mL | 0.0556 mL | 0.1112 mL | 0.2781 mL |
Bacopasaponin C Related Classifications
HY-N6015 Related Classifications
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