Antileishmanial agent-40
Antileishmanial agent-40 is an orally active and selective antileishmanial agent. Antileishmanial agent-40 elevates intracellular reactive oxygen species (ROS) levels in Leishmania donovani promastigotes. Antileishmanial agent-40 induces cell cycle arrest at the sub-G0/G1 phase in Leishmania donovani promastigotes, indicative of programmed-like parasite death. Antileishmanial agent-40 can be used for the research of leishmaniasis.
For research use only. We do not sell to patients.
- Formula: C22H31BrN4
- Molecular Weight:431.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Leishmania |
Antileishmanial agent-40 (Compound 19e) (2-16 μg/mL; 48 h) exhibits moderate cytotoxicity toward RAW 264.7 macrophages with a CC50 of 7.56 μg/mL[1].
Antileishmanial agent-40 (2-16 μg/mL; 48 h) potently inhibits Leishmania donovani promastigote growth with an IC50 of 1.86 μg/mL[1].
Antileishmanial agent-40 (1.86 μg/mL; 48 h) induces pronounced cell cycle arrest in Leishmania donovani promastigotes, with 66.9% of cells accumulating in the sub-G0/G1 phase[1].
Antileishmanial agent-40 (1.86 μg/mL; 48 h) induces a significant 4.72-fold increase in intracellular reactive oxygen species levels in Leishmania donovani promastigotes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Leishmania donovani promastigotes
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Concentration:1.86 μg/mL
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Incubation Time:48 h
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Result:Significantly increased the proportion of L. donovani promastigotes in the sub-G0/G1 phase to 66.9% (p < 0.001), compared to 6.8% in untreated parasites and 56.0% in miltefosine-treated parasites.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 24-25 g, acute oral toxicity model)[1]
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Dosage:0.5 mg/kg; 1 mg/kg; 2 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
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Administration:p.o.; single dose
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Result:Showed no mortality, abnormal behavior, or visible toxicity signs across all dose groups.
Exhibited negligible body weight changes.
Demonstrated no significant hematological alterations compared to controls.
Revealed normal tissue architecture in liver, spleen, and kidney, with only minor, non-significant alterations in the 10 and 20 mg/kg groups.
Caused significantly elevated serum urea (25.97 mg/dl) and creatinine (0.73 mg/dl) compared to controls at 10 mg/kg, with no change in uric acid.
Induced significantly elevated serum urea (26.03 mg/dl), creatinine (0.80 mg/dl), uric acid (5.10 mg/dl), ALT, AST, and ALP levels, plus slightly elevated cholesterol (184.3 mg/dl), triglycerides, HDL, LDL, and VLDL levels compared to controls at 20 mg/kg.
Showed all elevated values remained within reference ranges.
Noted no significant biochemical toxicity at 0.5, 1, 2, or 5 mg/kg.
Chemical Information
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Molecular Weight 431.41
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Formula C22H31BrN4
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SMILES
CCCCC1=NN2C(C3=CC=C(Br)C=C3N=C2NC(C)(C)CC(C)(C)C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-40 Related Classifications
HY-183262 Related Classifications
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- Antileishmanial agent-40
- Antileishmanial agent40
- Antileishmanial agent 40
- Parasite
- Reactive Oxygen Species (ROS)
- sub-G0/G1 phase
- programmed-like parasite death
- BALB/c mice
- RAW 264.7 macrophages
- reactive oxygen species
- mammalian cells
- leishmaniasis
- Leishmania donovani promastigotes
- cell cycle arrest
- Inhibitor
- inhibitor
- inhibit