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Cat. No.: HY-161325

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Antileishmanial agent-26

Antileishmanial agent-26 (Compound 69) is a guanidine-containing compound with anti-Leishmania donovani activity. Its IC₅₀ value against Leishmania donovani is 5.67 μM, and its CC₅₀ value against THP-1 is 3.79 μM. Antileishmanial agent-26 can be used in the research of tropical diseases.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₇FN₄O₂
Molecular Weight:410.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antileishmanial agent-26 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
THP-1	CC₅₀	3.79 μM Compound: 69	Cytotoxicity against human THP-1 cells incubated for 72 hrs by DAPI staining based analysis Cytotoxicity against human THP-1 cells incubated for 72 hrs by DAPI staining based analysis	[PMID: 38461679]

Chemical Information

Molecular Weight 410.48
Formula C₂₃H₂₇FN₄O₂
SMILES

COC1=CC2=C(N(C)C)N=C(NCC3=CC=C(F)C=C3)N=C2C=C1OC4CCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Das N, et al. Hit-to-lead optimization of 2-aminoquinazolines as anti-microbial agents against Leishmania donovani[J]. European Journal of Medicinal Chemistry, 2024: 116256.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Antileishmanial agent-26

All Parasite Isoforms