Nummularine B  (Synonyms: Daechuine S27; N-Demethylamphibine H)

Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC₅₀ of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca²⁺-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis^[1][2][3].

Nummularine B inhibits the growth of the K1 strain of Plasmodium falciparum, with an IC₅₀ of 3.6 μM^[1].
Nummularine B (20 min) inhibits calmodulin-dependent Ca²⁺-ATPase activity in actomyosin from rat posterior thigh muscle, with an IC₅₀ of 27.0 μM^[2].
Nummularine B (10 min) inhibits the activity of calmodulin-dependent phosphodiesterase from bovine brain-derived enzymes, with an IC₅₀ value of 16.8 μM^[2].
Nummularine B (Compound 11) (72 h (T. b. rhodesiense, L. donovani, P. falciparum); 96 h (T. cruzi)) potently inhibits Plasmodium falciparum with an IC₅₀ of 14.7 μM; it also inhibits Leishmania donovani with an IC₅₀ of 44.8 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

591.71

C₃₂H₄₁N₅O₆

53947-96-9

{Me-Ala}-Val-Cyclo({N-[(1Z)-2-(5-hydroxy-2-methoxyphenyl)ethenyl]-Pro}-Phe) (lactam bridge: Pro3-Phe4)

{Me-Ala}-V-Cyclo({N-[(1Z)-2-(5-hydroxy-2-methoxyphenyl)ethenyl]-Pro}-F) (lactam bridge: Pro3-Phe4)

C([C@@H](NC([C@@H](NC)C)=O)C(C)C)(=O)N1[C@]2([C@@](OC=3C=C(C(OC)=CC3)/C=C\NC(=O)[C@H](CC4=CC=CC=C4)NC2=O)(CC1)[H])[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tuenter E, et al. Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide Alkaloids. Molecules. 2017;22(2):224. Published 2017 Feb 2.

  [2]. Hwang KH, et al. Inhibition of calmodulin-dependent calcium-ATPase and phosphodiesterase by various cyclopeptides and peptide alkaloids from the Zizyphus species. Arch Pharm Res. 2001;24(3):202-206.

  [3]. Sevik Kilicaslan O, et al. Antiprotozoal activity of natural products from Nigerien plants used in folk medicine. Front Pharmacol. 2023;14:1190241. Published 2023 Jun 23.