Inhibition of calmodulin-dependent calcium-ATPase and phosphodiesterase by various cyclopeptides and peptide alkaloids from the Zizyphus species

  • Arch Pharm Res. 2001 Jun;24(3):202-6. doi: 10.1007/BF02978257.
K H Hwang  1 ,  Y N Han ,  B H Han
Affiliations
  • 1. Natural Products Research Institute, Seoul National University, Korea.
PMID: 11440077 DOI: 10.1007/BF02978257
Abstract

The effects of various sedative Cyclopeptides and peptide Alkaloids from the Zizyphus species on calmodulin-dependent Ca2+-ATPase and phosphodiesterase were investigated. Calmodulin-induced activation of Ca2+-ATPase was strongly inhibited by sanjoinine-A dialdehyde (IC0O, 2.3 microM), -Ah1 (IC50, 4.0 microM), -A (IC50, 4.6 microM), and -G2 (IC50, 7.2 microM), while calmodulin-induced activation of phosphodiesterase was strongly inhibited by both deachuine-S10 (IC30, 4.9 microM) and sanjoinine-D (IC50, 9.0 microM). The inhibitory activity of the various Cyclopeptides and peptide Alkaloids on Ca2+-ATPase was found to correlate well with their sedative activity.

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