2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Parasite Reactive Oxygen Species (ROS)
  4. Antileishmanial agent-41

Antileishmanial agent-41 (Compound 20k) is a selective Antileishmanial agent with a IC50 of 1.51 μg/mL against Leishmania donovani. Antileishmanial agent-41 increases ROS levels. Antileishmanial agent-41 can be used for the research of leishmaniasis.

For research use only. We do not sell to patients.

Antileishmanial agent-41

Antileishmanial agent-41 Chemical Structure

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Antileishmanial agent-41 Related Antibodies

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Description

Antileishmanial agent-41 (Compound 20k) is a selective Antileishmanial agent with a IC50 of 1.51 μg/mL against Leishmania donovani. Antileishmanial agent-41 increases ROS levels. Antileishmanial agent-41 can be used for the research of leishmaniasis[1].

IC50 & Target[1]

Leishmania

1.51 μg/mL (IC50)

In Vitro

Antileishmanial agent-41 (48 h) exhibits moderate cytotoxicity against RAW 264.7 murine macrophages, with a CC50 value of 6.72 μg/mL[1].
Antileishmanial agent-41 (2-16 μg/mL; 48 h) potently inhibits the growth of Leishmania donovani promastigotes, with an IC50 of 1.51 μg/mL[1].
Antileishmanial agent-41 (1.51 μg/mL; 48 h) induces significant G0/G1 subphase cell cycle arrest in promastigotes of Leishmania donovani[1].
Antileishmanial agent-41 (1.51 μg/mL; 48 h) significantly increases the intracellular reactive oxygen species level in promastigotes of *Leishmania donovani*. After treatment at its IC50 concentration for 48 h, it induces a 5.66-fold increase compared with the untreated control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antileishmanial agent-41 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: Leishmania donovani promastigotes
Concentration: 1.51 μg/mL (IC50 concentration)
Incubation Time: 48 h
Result: Significantly increased the proportion of L. donovani promastigotes in the sub-G0/G1 phase to 65.0% (p < 0.001), compared to 6.8% in untreated controls.
Showed cell cycle arrest comparable to amphotericin B and higher than miltefosine.
In Vivo

Antileishmanial agent-41 (20k) (0.5-20 mg/kg; p.o.; single dose), alongside compound 19e, is well tolerated in female BALB/c mice at oral doses up to 20 mg/kg, with no mortality or overt toxicity and only mild, reference-range biochemical changes at the highest tested doses[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 24-25 g)[1]
Dosage: 0.5 mg/kg; 1 mg/kg; 2 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration: p.o.; single dose
Result: Showed no mortality, abnormal behavior, or visible toxicity signs across all dose groups.
Exhibited negligible body weight changes.
Demonstrated no significant hematological alterations compared to controls.
Revealed normal tissue architecture in liver, spleen, and kidney, with only minor, non-significant alterations in the 10 and 20 mg/kg groups.
Caused slightly elevated serum urea, creatinine, uric acid, cholesterol, triglycerides, HDL, LDL, VLDL, ALT, AST, and ALP levels versus controls at 10 and 20 mg/kg, with all values remaining within reference ranges.
Showed no significant biochemical signs of toxicity in the 0.5 and 1 mg/kg groups.
Molecular Weight

351.33

Formula

C16H16F3N5O
SMILES

NC1=NC2=CC=C(NC(C(F)(F)F)=O)C=C2C3=CC(CCCC)=NN31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antileishmanial agent-41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-41Antileishmanial agent41Antileishmanial agent 41ParasiteReactive Oxygen Species (ROS)programmed-like parasite deathBALB/c micesub-G0/G1 phaseRAW 264.7 murine macrophagesepithelial cellsLeishmania donovani promastigotesintracellular reactive oxygen speciesimmune cellsvisceral leishmaniasisInhibitorinhibitorinhibit

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