Antileishmanial agent-41
Antileishmanial agent-41 (Compound 20k) is a selective Antileishmanial agent with a IC50 of 1.51 μg/mL against Leishmania donovani. Antileishmanial agent-41 increases ROS levels. Antileishmanial agent-41 can be used for the research of leishmaniasis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3126462-44-7
- 分子式: C16H16F3N5O
- 分子量:351.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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生物活性
製品説明
IC50 & Target
[1]|
Leishmania 1.51 μg/mL (IC50) |
体外実験
Antileishmanial agent-41 (48 h) exhibits moderate cytotoxicity against RAW 264.7 murine macrophages, with a CC50 value of 6.72 μg/mL[1].
Antileishmanial agent-41 (2-16 μg/mL; 48 h) potently inhibits the growth of Leishmania donovani promastigotes, with an IC50 of 1.51 μg/mL[1].
Antileishmanial agent-41 (1.51 μg/mL; 48 h) induces significant G0/G1 subphase cell cycle arrest in promastigotes of Leishmania donovani[1].
Antileishmanial agent-41 (1.51 μg/mL; 48 h) significantly increases the intracellular reactive oxygen species level in promastigotes of *Leishmania donovani*. After treatment at its IC50 concentration for 48 h, it induces a 5.66-fold increase compared with the untreated control group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Leishmania donovani promastigotes
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Concentration:1.51 μg/mL (IC50 concentration)
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Incubation Time:48 h
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Result:Significantly increased the proportion of L. donovani promastigotes in the sub-G0/G1 phase to 65.0% (p < 0.001), compared to 6.8% in untreated controls.
Showed cell cycle arrest comparable to amphotericin B and higher than miltefosine.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 24-25 g)[1]
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Dosage:0.5 mg/kg; 1 mg/kg; 2 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
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Administration:p.o.; single dose
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Result:Showed no mortality, abnormal behavior, or visible toxicity signs across all dose groups.
Exhibited negligible body weight changes.
Demonstrated no significant hematological alterations compared to controls.
Revealed normal tissue architecture in liver, spleen, and kidney, with only minor, non-significant alterations in the 10 and 20 mg/kg groups.
Caused slightly elevated serum urea, creatinine, uric acid, cholesterol, triglycerides, HDL, LDL, VLDL, ALT, AST, and ALP levels versus controls at 10 and 20 mg/kg, with all values remaining within reference ranges.
Showed no significant biochemical signs of toxicity in the 0.5 and 1 mg/kg groups.
化学情報
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CAS 番号 3126462-44-7
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分子量 351.33
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分子式 C16H16F3N5O
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SMILES
NC1=NC2=CC=C(NC(C(F)(F)F)=O)C=C2C3=CC(CCCC)=NN31
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antileishmanial agent-41 関連分類
HY-183290 関連分類
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Keywords
- Antileishmanial agent-41
- 3126462-44-7
- Antileishmanial agent41
- Antileishmanial agent 41
- Parasite
- Reactive Oxygen Species (ROS)
- programmed-like parasite death
- BALB/c mice
- sub-G0/G1 phase
- RAW 264.7 murine macrophages
- epithelial cells
- Leishmania donovani promastigotes
- intracellular reactive oxygen species
- immune cells
- visceral leishmaniasis
- Inhibitor
- inhibitor
- inhibit