Search Result
Results for "
protein thiols
" in MedChemExpress (MCE) Product Catalog:
16
Biochemical Assay Reagents
5
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W011500
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Tris(2-carboxyethyl)phosphine hydrochloride
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Drug Derivative
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Others
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TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
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- HY-B0496
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PMSF
Maximum Cited Publications
146 Publications Verification
Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride
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Cathepsin
Ser/Thr Protease
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Neurological Disease
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PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates .
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- HY-W010572
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alpha-Thioglycerol
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Biochemical Assay Reagents
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Others
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1-Thioglycerol, commonly used as a reducing agent in various biochemical and biophysical applications, especially in protein chemistry and molecular biology, it can protect proteins from oxidation and denaturation, and can reduce disulfide bonds to thiols base, which can then be modified or analyzed. In addition, 1-Thioglycerol has been investigated for potential medical applications, including as an inhibitor of cystic fibrosis, which may help improve the function of lung cells, and has also been studied for Used in the preparation of metal nanoparticles and as a stabilizer for certain pharmaceutical preparations.
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- HY-136769
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Biochemical Assay Reagents
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Others
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Biotin-HPDP is a biochemical reagent. Biotin-HPDP can couple with GMPS and label free protein thiols. Biotin-HPDP can be used as a biological material or organic compound for life science related research .
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- HY-138200
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Cyanine5 maleimide
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DNA Stain
Fluorescent Dye
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Others
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Cy5 maleimide (Cyanine5 maleimide) is a single-reactive dye containing a maleimide group and a CY5 fluorescent group, which can selectively couple with a thiol group. Cy5 maleimide can be used to label antibodies, peptides, or proteins (Ex/Em = 646/664 nm).
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- HY-143218
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TPE-MI
Maximum Cited Publications
14 Publications Verification
Tetraphenylethene maleimide
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Huntingtin
Parasite
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Infection
Neurological Disease
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TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasites Plasmodium falciparum .
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- HY-140739
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Liposome
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Neurological Disease
Cancer
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DSPE-PEG2000-Maleimide sodium (purity>95%) is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide sodium (purity>95%) can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .
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- HY-NP008
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Lipocalin Family
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Inflammation/Immunology
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β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .
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- HY-D0098
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N-(5-Fluoresceinyl)maleimide
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Fluorescent Dye
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Others
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Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .
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- HY-15941
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Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers
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Fluorescent Dye
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Others
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5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .
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- HY-D2906
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Fluorescent Dye
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Others
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Alexa fluor 647 maleimide is a bright, far-red-emitting fluorescent dye for labeling of protein SH groups (Ex/Em = 656/670 nm). Alexa fluor 647 maleimide can be used to attach AF 647 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Alexa Fluor 647 maleimide is promising for research of cell biology, neuroscience, and disease diagnostics .
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- HY-D1605
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Fluorescent Dye
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Others
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BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λex=504 nm, λem=511 nm) .
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- HY-D0807
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5-IAF
1 Publications Verification
5-Iodoacetamidofluorescein
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Fluorescent Dye
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Cancer
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5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .
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- HY-W011500S
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Isotope-Labeled Compounds
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Others
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TCEP-d16 (hydrochloride) is the deuterium labeled TCEP hydrochloride . TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
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- HY-123749
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5-TMRIA
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Fluorescent Dye
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Others
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Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues. Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) can be used to covalently label DNA fragments .
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- HY-12638
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DDM
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Environmental Pollutants
Fungal
Parasite
Bacterial
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Infection
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Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .
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- HY-W998680
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5-FITC-Maleimide
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Fluorescent Dye
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Others
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Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .
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- HY-D1781
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Fluorescent Dye
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Others
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NTPAN-MI is a fluorescent probe (excitation wavelength: 405 nm). NTPAN-MI is selectively activated after labeling unfolded proteins with exposed thiols, thereby reporting the degree of protein homeostasis .
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- HY-B1217
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BNPD; BNPK
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Environmental Pollutants
Bacterial
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Infection
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Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser .
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- HY-D2381
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Fluorescent Dye
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Others
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AF 488 maleimide is a thiol-reactive dye used to label SH groups of proteins, which can attach the AF 488 fluorophore to cysteine residue-containing proteins and peptides as well as other thiolated molecules. AF 488 maleimide enables real-time visualization of dynamic pilus extension and retraction in live bacterial cells via epifluorescence microscopy (Ex/Em = 470/520 nm) .
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- HY-D1390A
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Fluorescent Dye
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Others
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Sulfo-Cy5-Mal is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .
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- HY-164159
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Reactive Oxygen Species (ROS)
MMP
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Inflammation/Immunology
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α-Glucosylrutin, a flavonoid, is a potent antioxidant with free radical scavenging activity. α-Glucosylrutin reduces MMP-1 gene expression, protein expression, and enzyme activity, and reduces MMP-2 protein expression and enzyme activity in UVA-irradiated human dermal fibroblasts. α-Glucosylrutin prevents oxidative stress-induced intracellular tyrosine residue phosphorylation and counteracts intracellular thiol level depletion in human skin cells. α-Glucosylrutin is effective in the prevention of dermatologic diseases in which oxidative stress is of pathogenetic relevance, e.g. in polymorphous light eruption (PLE). α-Glucosylrutin can be used for the research of UV-induced skin photodamage/photoaging .
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- HY-130509
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Otmpmms
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Biochemical Assay Reagents
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Others
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MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .
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- HY-148263
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Fluorescent Dye
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Cancer
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Biotin-PEG2000-Thiol is an active compound. Biotin-PEG2000-Thiol is pegylated by binding to streptavidin or antibiotin with high affinity and specificity. Biotin-PEG2000-Thiol can modify biomolecules, proteins, peptides and other small molecule materials. Biotin-PEG2000-Thiol is widely used in the research of agent release and nano new materials .
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- HY-107783
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Biochemical Assay Reagents
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Others
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Sulfo-GMBS is a crosslinker widely used in chemical modification and coupling reactions of proteins and peptides. Among amine-thiol crosslinkers, Sulfo-GMBS generates the largest number of crosslinks and covers most of the crosslinks identified by AMAS and GMBS .
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- HY-D1590
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Fluorescent Dye
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Others
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ODIPY Green 8-P2M is a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore, the fluorescence is strongly quenched by d-PeT and then can be restored after reaction with thiol, resulting in an extremely high signal-to-noise ratio. ODIPY Green 8-P2M can be useful for detecting extremely low concentrations of protein in the gel after SDS-PAGE .
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- HY-137541
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NTCB
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Biochemical Assay Reagents
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Others
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2-Nitro-5-thiocyanatobenzoic acid (NTCB) is a highly reactive reagent that transfers its cyano group rapidly to a nucleophilic thiolate. 2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives .
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- HY-D1871
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Fluorescent Dye
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Others
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Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
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- HY-W012184
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Biochemical Assay Reagents
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Inflammation/Immunology
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CDAP is an organic cyanylating reagent that can be used for preparation of solid phase affinity reagents, modification of protein thiols and nucleotide delivery. CDAP also activates polysaccharides with a variety of chemical properties. CDAP can be used to prepare conjugate vaccines and other immune reagents .
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- HY-D1261
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Thiol-green 1
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Fluorescent Dye
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Others
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Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells . Ex: 488 nM; Em: 540 nM.
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- HY-W106411
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Dithio-bis-maleimidoethane
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Biochemical Assay Reagents
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Others
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DTME (dithio-bis-maleimidoethane) is a homobifunctional, maleimide crosslinker specifically designed for conjugation between sulfhydryl groups (-SH). DTME, whose molecular structure consists of two maleimide groups connected by an ethylene disulfide bridge, can specifically react with thiol - containing molecules (such as cysteine residues) to form stable covalent bonds. DTME allows crosslinks that can be cleaved with reducing agents such as DTT (HY-15917). DTME is commonly utilized to explore and characterize protein structure, particularly oligomerization, or protein interactions .
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- HY-119493
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Fluorescent Dye
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Others
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MSBN is a highly selective fluorogenic probe for thiols. MSBN can be used to image thiols in live cells selectively and specifically label protein thiols with a signal to determine various reversible protein thiol modifications .
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- HY-D2498
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Fluorescent Dye
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Others
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Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .
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- HY-W012166
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NHS-Bromoacetate
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Biochemical Assay Reagents
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Infection
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N-Succinimidyl bromoacetate (NHS-Bromoacetate) is a heterobifunctional crosslinking reagent, mainly used to modify the ɛ-amino group of lysine side chains. By covalently linking its bromoacetyl moiety to the ɛ-amino group of lysine in peptidomimetics, N-Succinimidyl bromoacetate enables their conjugation with thiol-modified nanoparticles via thioether bonds. N-Succinimidyl bromoacetate also performs bromoacetylation modification on carrier proteins, which then forms stable thioether bonds with the thiol groups of cysteine in peptides, thus efficiently preparing soluble peptide-protein conjugates with high substitution ratios. N-Succinimidyl bromoacetate can be used to prepare activated Sepharose derivatives for affinity chromatography, protein affinity labeling reagents, and peptide-protein immunogen conjugates with non-immunogenic linkages. N-Succinimidyl bromoacetate is applicable to studies related to HIV-1 infection and glioblastoma multiforme .
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- HY-136913
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(Rac)-Betuligenol
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Endogenous Metabolite
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Inflammation/Immunology
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(Rac)-Rhododendrol ((Rac)-Betuligenol) is an aromatic compound with pro-oxidant activity. (Rac)-Rhododendrol may be useful in the suppression of liver diseases. (Rac)-Rhododendrol can be toxic to melanocytes, leading to cell death. The metabolite of (Rac)-Rhododendrol, RD-quinone, is cytotoxic and causes enzyme inactivation and endoplasmic reticulum stress by binding to thiol proteins. (Rac)-Rhododendrol-derived melanin exhibits potent pro-oxidant activity and may cause oxidative stress .
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- HY-P4087
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HIV
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Infection
Cancer
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Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection .
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- HY-D1260
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PSH-red
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Fluorescent Dye
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Neurological Disease
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FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
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- HY-W020780D
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Biochemical Assay Reagents
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Others
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mPEG40000-Mal is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .
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- HY-DY1024
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Huntingtin
Parasite
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Infection
Neurological Disease
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TPE-MI (Tetraphenylethene maleimide) (solution) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .
Solvent and concentration: DMSO: 10 mM
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- HY-W1048851B
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4-Arm-PEG10000-Mal
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Biochemical Assay Reagents
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Others
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4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation .
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- HY-P2927
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PDI
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Cardiovascular Disease
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Protein disulfide isomerase is a prototypic thiol isomerase that catalyzes the formation and cleavage of thiol-disulfide bonds during protein folding in the endoplasmic reticulum (ER). Protein disulfide isomerase can be used for the study of cardiovascular diseases .
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- HY-135133
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- HY-W776833
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Otmpmms-15N,d15
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Isotope-Labeled Compounds
Biochemical Assay Reagents
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Others
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MTSSL- 15N,d15-1 (Otmpmms- 15N,d15) is the deuterium and 15N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .
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- HY-E70264
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Endogenous Metabolite
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Metabolic Disease
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16:0 Coenzyme A triammonium is palmitoyl-CoA, which can serve as a reaction substrate to transfer the palmitoyl group to the free thiol group of the target protein through palmitoylation catalyzed by protein acyl transferases (PATs) .
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- HY-W020780C
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mPEG3400-Maleimide
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Biochemical Assay Reagents
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Others
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mPEG3400-Mal is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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- HY-D2488
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Fluorescent Dye
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Others
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Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.
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- HY-D1406
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Fluorescent Dye
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Others
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L-Biotin-NH-5MP-Br is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .
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- HY-155901
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Maleimide-NH-PEG2000-amine TFA
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Biochemical Assay Reagents
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Others
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Mal-NH-PEG2000-NH2TFA is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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- HY-172721
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Fluorescent Dye
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Others
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Cy3B maleimide is a mono-reactive dye containing maleimide group, which can selectively and efficiently attach Cyanine3 fluorophore (an analog of Cy3) to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Cy3B is an improved version of Cy3 dyes with significantly increased fluorescence quantum yield and photostability.
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- HY-W615327
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Biochemical Assay Reagents
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Others
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Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
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- HY-P4087B
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HIV
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Others
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Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection .
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- HY-118112
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Biochemical Assay Reagents
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Others
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4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.
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- HY-106981
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OR 1384
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NADPH Oxidase
Reactive Oxygen Species (ROS)
Apoptosis
NF-κB
NO Synthase
STAT
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Inflammation/Immunology
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Orazipone (OR 1384) is a small molecule immunomodulator with strong anti-inflammatory properties. Orazipone exerts its immunomodulatory effect by forming reversible thiol complexes, which bind to intracellular signaling proteins and the thiol groups of glutathione. Orazipone exhibits potent anti-eosinophilic activity by inducing apoptosis. Orazipone inhibits activation of inflammatory transcription factors NF-kB and STAT 1 and decreases inducible iNOS expression and NO production in response to inflammatory stimuli. Orazipone reduces NADPH oxidase activity and thereby decreases ROS production. Orazipone has a protective effect in intestinal radiation injury .
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- HY-157920
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N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine
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Biochemical Assay Reagents
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Others
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Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
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- HY-168448
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PROTACs
Epigenetic Reader Domain
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Cancer
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dBAZ2 is a first-in-class BAZ2A and BAZ2B PROTAC degrader with DC50 values of 180 nM and 250 nM for BAZ2A and BAZ2B, respectively. (Blue: E3 ligase ligand (VH 101, thiol (HY-47851); Black: linker (HY-168450); pink: target protein ligand (HY-168449)) .
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- HY-172291
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ADC Linker
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Cancer
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Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker featuring a maleimide, a PEG spacer, a Val-Cit dipeptide, a PAB. and a PNP carbonate. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP group acts as a highly activated leaving group. Val-Cit linkers are cleaved by cytoplasmic peptidases.
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- HY-D1390
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Fluorescent Dye
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Others
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Sulfo-Cy5-Mal potassium is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal potassium specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal potassium can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .
|
-
- HY-140739A
-
|
|
Liposome
|
Neurological Disease
Cancer
|
|
DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide free acid utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide free acid covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide free acid can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .
|
-
- HY-D1526
-
|
|
Fluorescent Dye
|
Others
|
|
N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λex=355 nm, λem=448 nm .
|
-
- HY-130509S
-
|
Otmpmms-15N
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
MTSSL- 15N (Otmpmms- 15N) is the 15N-labeled MTSSL (HY-130509). MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies .
|
-
- HY-129846
-
|
|
Biochemical Assay Reagents
|
Others
|
|
IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific
reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols .
|
-
- HY-D1527
-
|
|
Fluorescent Dye
|
Others
|
|
N-(3-Fluoranthyl)maleimide is a thiol fluorescent probe with a lifetime of 20 nsec. N-(3-Fluoranthyl)maleimide has a maximum excitation wavelength of 370 nm and can be used to study the time-dependent processes of biopolymers .
|
-
- HY-E70615
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Protein Disulfide Isomerase, Human, an oxidoreductase, is a mainly endoplasmic reticulum (ER) resident protein. Protein Disulfide Isomerase, Human plays an important role in maintaining cellular homeostasis through thiol oxidation/reduction cycling, chaperone action, and isomerization of client proteins .
|
-
- HY-W020780A
-
|
mPEG350-Maleimide
|
Biochemical Assay Reagents
|
Others
|
|
mPEG350-Mal is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-W020780B
-
|
mPEG750-Maleimide
|
Biochemical Assay Reagents
|
Others
|
|
mPEG750-Mal is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-D1403
-
|
|
Fluorescent Dye
|
Cancer
|
|
L-Biotin-NH-5MP is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .
|
-
- HY-157919
-
|
N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]piperazine, hydrochloride
|
Biochemical Assay Reagents
|
Others
|
|
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .
|
-
- HY-W800682
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-Sulfone-PEG4-acid is a reagent with a sulfone and an acid. The sulfone group can be conjugated with thiol groups of proteins. The terminal acid reacts with primary amines with the help of activators (EDC or HATU) to from stable amide bonds.
|
-
- HY-173390
-
|
|
Drug Intermediate
Biochemical Assay Reagents
|
Others
|
|
BCN-E-BCN is a strained cycloalkyne-based probe designed for detecting protein sulfenylation, the primary intermediate in protein oxidation. This structurally constrained cycloalkyne compound specifically recognizes sulfenic acid groups formed during thiol oxidation, while remaining completely unreactive toward other oxidative states (such as free thiols, sulfinic, or sulfonic acid groups). Researchers can leverage its efficient conjugation with azide-bearing tags through copper-free click chemistry to amplify detection signals. Compared to conventional detection methods, BCN-E-BCN demonstrates superior reaction kinetics and enhanced sensitivity. With these advantages, BCN-E-BCN shows great promise as an effective tool for protein oxidation research .
|
-
- HY-W674381
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
5-(2-Chloroacetamide) thalidomide is a Thalidomide (HY-14658) analogue. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. This structure features a chloroacetamide, which is a thiol-specific reactive group.
|
-
- HY-D2094
-
|
|
Fluorescent Dye
|
Inflammation/Immunology
Cancer
|
|
PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .
|
-
- HY-W394551
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a small pyrrolidone molecule which features two bromine atoms and a methyl ester. The unsaturated dibromo motif is a covalent ligand for thiol groups, and may be used to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time. The methyl ester can be saponified to link this molecule to amines to form larger structures.
|
-
- HY-B1217S
-
|
BNPD-d4; BNPK-d4
|
Isotope-Labeled Compounds
Bacterial
|
Infection
|
|
Bronopol-d4 is deuterium labeled Bronopol. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser .
|
-
- HY-W700621
-
|
Tris(2-carboxyethyl)phosphine hydrochloride-d12
|
Isotope-Labeled Compounds
Others
|
Others
|
|
TCEP-d12 (hydrochloride) (Tris(2-?carboxyethyl)?phosphine hydrochloride-d12) is deuterium labeled TCEP (hydrochloride). TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry .
|
-
- HY-D1404
-
|
|
Fluorescent Dye
|
Others
|
|
5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-B1217R
-
|
BNPD (Standard); BNPK (Standard)
|
Reference Standards
Bacterial
|
Infection
|
|
Bronopol (Standard) is the analytical standard of Bronopol. This product is intended for research and analytical applications. Bronopol is an antibacterial agent with low toxicity (to mammals) and high activity (especially against Gram-negative bacteria). Bronopol oxidizes protein thiols, inhibits enzymatic activity, and exhibits antibacterial activity. Bronopol is also a formaldehyde releaser .
|
-
- HY-D1407
-
|
|
Fluorescent Dye
|
Others
|
|
Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W800720
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(S)-2-amino-4-(2-(pyridin-2-yl)disulfanyl)butanoic acid is a small molecule reagent with a 2-thiopyridine linked to a short amino acid. SPDP is a thiol-specific labeling reagent, commonly used in reversibly binding cysteine residues on proteins. The disulfide bond it forms with the cysteine is selectively cleaved in the reducing environment of the cell cytoplasm.
|
-
- HY-152919
-
|
|
ADC Linker
|
Cancer
|
|
Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. Maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery with the help of the PAB structure.
|
-
- HY-W440901
-
|
|
Liposome
|
Others
|
|
DSPE-PEG5000-SPDP is an amphiphilic polyPEG which forms lipid bilayer in water. It can be used to encapsualte therapeutic agents. The core can encapsulate hydrophilic nutrients, such as protein/peptide and mRNA/DNA/siRNA etc. while the lipid bilayer can solubilize hydrophobic drugs, such as doxorubicin, curcumin etc. The SPDP moiety can react with thiol molecule to form a disulfide bond.
|
-
- HY-12638R
-
|
DDM (Standard)
|
Reference Standards
Bacterial
Fungal
Parasite
|
Infection
|
|
Dichlorophen (Standard) is the analytical standard of Dichlorophen (HY-12638). This product is intended for research and analytical applications. Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections .
|
-
- HY-W190952
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-sulfone-PEG4-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.
|
-
- HY-W010572R
-
|
alpha-Thioglycerol (Standard)
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
1-Thioglycerol (Standard) is the analytical standard of 1-Thioglycerol. This product is intended for research and analytical applications. 1-Thioglycerol, commonly used as a reducing agent in various biochemical and biophysical applications, especially in protein chemistry and molecular biology, it can protect proteins from oxidation and denaturation, and can reduce disulfide bonds to thiols base, which can then be modified or analyzed. In addition, 1-Thioglycerol has been investigated for potential medical applications, including as an inhibitor of cystic fibrosis, which may help improve the function of lung cells, and has also been studied for Used in the preparation of metal nanoparticles and as a stabilizer for certain pharmaceutical preparations.
|
-
- HY-116748
-
|
|
PDI
Phosphatase
|
|
|
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pKa value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research .
|
-
- HY-W591469
-
|
|
Biochemical Assay Reagents
|
Others
|
|
mPEG1000-Mal is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .
|
-
- HY-E71171
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1,8-Cineole 2-exo-monooxygenase (EC 1.14.13.157) is a heme thiol protein (P-450) that catalyzes the oxidation of a variety of structurally unrelated compounds, including steroids, fatty acids, and exogenous substances.
|
-
- HY-W578278
-
|
|
Biochemical Assay Reagents
|
Others
|
|
tert-Butyl (2-(pyridin-2-yldisulfanyl)ethyl)carbamate consists of a tert-butyl group, where the protected amine can be deprotected under mild acidic conditions, and the other part of the molecule may act as a thiol-specific labeling reagent, commonly used in reversibly binding cysteine residues on proteins.
|
-
- HY-D2763
-
|
|
Fluorescent Dye
|
Others
|
|
BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.
Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.
|
-
- HY-W591360
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
|
-
- HY-W721611
-
|
|
Herbicide
|
Others
|
|
Terbucarb is a phenylcarbamate herbicide. Terbucarb disrupts the mitotic microtubule organizing centers in plant cells, leading to the formation of multipolar spindles and branched phragmoplasts, thereby inhibiting plant growth. An "anaphase star" pattern induced by Terbucarb is observed in onion root tips. Terbucarb is cytotoxic to isolated rat hepatocytes, inducing cell death accompanied by depletion of intracellular ATP, protein thiols and glutathione .
|
-
- HY-W800627
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-sulfone-PEG8-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.
|
-
- HY-N19808
-
|
|
Drug Derivative
|
Cancer
|
|
2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma .
|
-
- HY-181737
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Others
|
|
E3 Ligase Ligand-linker Conjugate 225 is an E3 ligase ligand-linker conjugate used for the synthesis of PROTACs; it consists of the PEG-based linker Bis-Tos-PEG3 (HY-W013731) and the VHL-type E3 ubiquitin ligase ligand VH 101 thiol (HY-47851). E3 Ligase Ligand-linker Conjugate 225 can be further coupled with a target protein ligand—such as MT-4 (HY-128595)—to synthesize the PROTAC TG2 Degrader-3 (HY-181732) .
|
-
- HY-DY1088
-
|
N-(5-Fluoresceinyl)maleimide (solution)
|
Fluorescent Dye
|
Others
|
Fluorescein-5-maleimide (solution) (N-(5-Fluoresceinyl)maleimide (solution)) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .
Solvent and concentration: DMSO: 10 mM
|
-
- HY-183740
-
|
N-Acryloylindole-alkyne
|
Biochemical Assay Reagents
|
Others
|
|
NAIA (N-Acryloylindole-alkyne) is a cysteine-reactive probe. NAIA can be used as an imaging agent, proteome profiling agent, and covalent ligand screening tool .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-138200
-
|
Cyanine5 maleimide
|
Fluorescent Dyes
|
|
Cy5 maleimide (Cyanine5 maleimide) is a single-reactive dye containing a maleimide group and a CY5 fluorescent group, which can selectively couple with a thiol group. Cy5 maleimide can be used to label antibodies, peptides, or proteins (Ex/Em = 646/664 nm).
|
-
- HY-143218
-
TPE-MI
Maximum Cited Publications
14 Publications Verification
Tetraphenylethene maleimide
|
Fluorescent Dyes
|
|
TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasites Plasmodium falciparum .
|
-
- HY-D0098
-
|
N-(5-Fluoresceinyl)maleimide
|
Fluorescent Dyes
|
Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .
|
-
- HY-15941
-
|
Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers
|
Fluorescent Dyes
|
|
5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .
|
-
- HY-D2906
-
|
|
Fluorescent Dyes
|
|
Alexa fluor 647 maleimide is a bright, far-red-emitting fluorescent dye for labeling of protein SH groups (Ex/Em = 656/670 nm). Alexa fluor 647 maleimide can be used to attach AF 647 fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Alexa Fluor 647 maleimide is promising for research of cell biology, neuroscience, and disease diagnostics .
|
-
- HY-D1605
-
|
|
Fluorescent Dyes
|
|
BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λex=504 nm, λem=511 nm) .
|
-
- HY-D0807
-
5-IAF
1 Publications Verification
5-Iodoacetamidofluorescein
|
Fluorescent Dyes
|
|
5-IAF (5-Iodoacetamidofluorescein) is an idoacetamide derivate of fluoresceine. 5-IAF can be used as fluorescent probe that labels proteins and other molecules having free thiols (cysteine side chains) .
|
-
- HY-123749
-
|
5-TMRIA
|
Fluorescent Dyes
|
|
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues. Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) can be used to covalently label DNA fragments .
|
-
- HY-W998680
-
|
5-FITC-Maleimide
|
Fluorescent Dyes
|
|
Fluorescein-maleimide (5-FITC-Maleimide) is a thiol-reactive fluorescent derivatization reagent and non-specific protein labeling reagent. Fluorescein-maleimide covalently binds to protein thiol groups for protein labeling. Fluorescein-maleimide covalently binds to protein amino and imidazole groups under neutral pH conditions. Fluorescein-maleimide is used for fluorescent labeling of proteins, nucleic acids or other molecules containing one or more thiol groups (Ex/Em = 494/519 nm) .
|
-
- HY-D1781
-
|
|
Fluorescent Dyes
|
|
NTPAN-MI is a fluorescent probe (excitation wavelength: 405 nm). NTPAN-MI is selectively activated after labeling unfolded proteins with exposed thiols, thereby reporting the degree of protein homeostasis .
|
-
- HY-D2381
-
|
|
Fluorescent Dyes
|
|
AF 488 maleimide is a thiol-reactive dye used to label SH groups of proteins, which can attach the AF 488 fluorophore to cysteine residue-containing proteins and peptides as well as other thiolated molecules. AF 488 maleimide enables real-time visualization of dynamic pilus extension and retraction in live bacterial cells via epifluorescence microscopy (Ex/Em = 470/520 nm) .
|
-
- HY-D1390A
-
|
|
Fluorescent Dyes
|
|
Sulfo-Cy5-Mal is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .
|
-
- HY-D1871
-
|
|
Fluorescent Dyes
|
|
Cy3 maleimide chloride is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing maleimide functional groups. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The alkyne functional group of Cy3 maleimide chloride can undergo a "thiol-acrylamide" reaction with molecules containing sulfur-oxygen functional groups to form covalent bonds. Cy3 maleimide chloride can bind to biological molecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
|
-
- HY-D1261
-
|
Thiol-green 1
|
Fluorescent Dyes
|
|
Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells . Ex: 488 nM; Em: 540 nM.
|
-
- HY-D2498
-
|
|
Fluorescent Dyes
|
|
Cy7 maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides .
|
-
- HY-D1260
-
|
PSH-red
|
Fluorescent Dyes
|
|
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
|
-
- HY-DY1024
-
|
|
Fluorescent Dyes
|
TPE-MI (Tetraphenylethene maleimide) (solution) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .
Solvent and concentration: DMSO: 10 mM
|
-
- HY-D2488
-
|
|
Fluorescent Dyes
|
|
Sulfo Cy5.5-maleimide is a fluorescent dye containing a Maleimide (HY-W007324) functional group. Maleimide can be used to label thiol groups on antibodies, proteins and peptides.
|
-
- HY-D1406
-
|
|
Fluorescent Dyes
|
|
L-Biotin-NH-5MP-Br is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .
|
-
- HY-172721
-
|
|
Fluorescent Dyes
|
|
Cy3B maleimide is a mono-reactive dye containing maleimide group, which can selectively and efficiently attach Cyanine3 fluorophore (an analog of Cy3) to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Cy3B is an improved version of Cy3 dyes with significantly increased fluorescence quantum yield and photostability.
|
-
- HY-D1390
-
|
|
Fluorescent Dyes
|
|
Sulfo-Cy5-Mal potassium is a fluorescent dye derivative composed of a CY5 dye and a maleimide functional group. Sulfo-Cy5-Mal potassium specifically covalently binds to thiol-containing (-SH) biomolecules. Sulfo-Cy5-Mal potassium can be used for protein labeling, antibody conjugation, molecular imaging, and drug delivery studies (Ex/Em = 633 nm/670 nm) .
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- HY-D1526
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Fluorescent Dyes
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N-(4-Anilino-1-naphthyl)maleimide is a fluorescent probe that can be used to detect thiol groups in proteins. N-(4-Anilino-1-naphthyl)maleimide reacts with thiol groups and immediately produces a stable fluorescent compound with the λex=355 nm, λem=448 nm .
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- HY-D1527
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Fluorescent Dyes
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N-(3-Fluoranthyl)maleimide is a thiol fluorescent probe with a lifetime of 20 nsec. N-(3-Fluoranthyl)maleimide has a maximum excitation wavelength of 370 nm and can be used to study the time-dependent processes of biopolymers .
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- HY-D1403
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Fluorescent Dyes
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L-Biotin-NH-5MP is a biotin-conjugated 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation .
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- HY-D2094
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Fluorescent Dyes
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PerCP Maleimide is a fluorescent dye that reacts with free sulfhydryl groups on proteins. PerCP is a red fluorescence albuminous dye for immunostaining and Maleimide can be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .
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- HY-D1404
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Fluorescent Dyes
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5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-D1407
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Fluorescent Dyes
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Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-D2763
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Fluorescent Dyes
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BP Fluor 532 maleimide is a photostable, bright yellow-fluorescent dye with pH insensitive emission from pH 4 to pH 10. The excitation of BP Fluor 532 is ideally suited for the frequency-doubled Nd:YAG laser line. BP Fluor 532 dye can be conjugated to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is often used for the generation of stable signals in imaging and flow cytometry.
Maleimide is the most popular sulfhydryl-reactive group for conjugating the dye to a thiol group on a protein, oligonucleotide thiophosphate, or low molecular weight ligand. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form a stable thioether bond. The resulting conjugates exhibit brighter fluorescence and greater photostability than the conjugates of many other spectrally similar fluorophores.
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- HY-DY1088
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N-(5-Fluoresceinyl)maleimide (solution)
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Fluorescent Dyes
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Fluorescein-5-maleimide (solution) (N-(5-Fluoresceinyl)maleimide (solution)) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .
Solvent and concentration: DMSO: 10 mM
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| Cat. No. |
Product Name |
Type |
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- HY-W010572
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alpha-Thioglycerol
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Biochemical Assay Reagents
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1-Thioglycerol, commonly used as a reducing agent in various biochemical and biophysical applications, especially in protein chemistry and molecular biology, it can protect proteins from oxidation and denaturation, and can reduce disulfide bonds to thiols base, which can then be modified or analyzed. In addition, 1-Thioglycerol has been investigated for potential medical applications, including as an inhibitor of cystic fibrosis, which may help improve the function of lung cells, and has also been studied for Used in the preparation of metal nanoparticles and as a stabilizer for certain pharmaceutical preparations.
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- HY-136769
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Biochemical Assay Reagents
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Biotin-HPDP is a biochemical reagent. Biotin-HPDP can couple with GMPS and label free protein thiols. Biotin-HPDP can be used as a biological material or organic compound for life science related research .
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- HY-140739
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Biochemical Assay Reagents
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DSPE-PEG2000-Maleimide sodium (purity>95%) is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide sodium (purity>95%) can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .
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- HY-NP008
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Biochemical Assay Reagents
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β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .
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- HY-W012184
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Biochemical Assay Reagents
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CDAP is an organic cyanylating reagent that can be used for preparation of solid phase affinity reagents, modification of protein thiols and nucleotide delivery. CDAP also activates polysaccharides with a variety of chemical properties. CDAP can be used to prepare conjugate vaccines and other immune reagents .
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- HY-W020780D
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Biochemical Assay Reagents
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mPEG40000-Mal is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .
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- HY-W1048851B
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4-Arm-PEG10000-Mal
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Biochemical Assay Reagents
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4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation .
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- HY-W020780C
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mPEG3400-Maleimide
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Biochemical Assay Reagents
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mPEG3400-Mal is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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- HY-155901
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Maleimide-NH-PEG2000-amine TFA
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Biochemical Assay Reagents
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Mal-NH-PEG2000-NH2TFA is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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- HY-157920
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N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine
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Biochemical Assay Reagents
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Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
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- HY-W020780A
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mPEG350-Maleimide
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Biochemical Assay Reagents
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mPEG350-Mal is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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- HY-W020780B
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mPEG750-Maleimide
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Biochemical Assay Reagents
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mPEG750-Mal is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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- HY-157919
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N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]piperazine, hydrochloride
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Biochemical Assay Reagents
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Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .
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- HY-W440901
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Biochemical Assay Reagents
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DSPE-PEG5000-SPDP is an amphiphilic polyPEG which forms lipid bilayer in water. It can be used to encapsualte therapeutic agents. The core can encapsulate hydrophilic nutrients, such as protein/peptide and mRNA/DNA/siRNA etc. while the lipid bilayer can solubilize hydrophobic drugs, such as doxorubicin, curcumin etc. The SPDP moiety can react with thiol molecule to form a disulfide bond.
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- HY-W010572R
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alpha-Thioglycerol (Standard)
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Biochemical Assay Reagents
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1-Thioglycerol (Standard) is the analytical standard of 1-Thioglycerol. This product is intended for research and analytical applications. 1-Thioglycerol, commonly used as a reducing agent in various biochemical and biophysical applications, especially in protein chemistry and molecular biology, it can protect proteins from oxidation and denaturation, and can reduce disulfide bonds to thiols base, which can then be modified or analyzed. In addition, 1-Thioglycerol has been investigated for potential medical applications, including as an inhibitor of cystic fibrosis, which may help improve the function of lung cells, and has also been studied for Used in the preparation of metal nanoparticles and as a stabilizer for certain pharmaceutical preparations.
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- HY-W591469
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Biochemical Assay Reagents
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mPEG1000-Mal is a thiol-reactive PEG derivative that can be used to selectively modify proteins, peptides, or any other surface with available thiol groups .
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P4087
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HIV
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Infection
Cancer
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Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection .
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- HY-P4087B
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HIV
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Others
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Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-N19808
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Structural Classification
Terpenoids
Sesquiterpenes
Plants
Compositae
Source Classification
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Drug Derivative
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2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma .
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-
| Cat. No. |
Product Name |
Chemical Structure |
| Cat. No. |
Product Name |
|
Classification |
-
- HY-D1404
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Alkynes
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|
5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . 5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-D1407
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|
|
|
Alkynes
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Br-5MP-Propargyl is the derivative of 5-Methylene pyrrolone (5MP). 5-Methylene pyrrolones (5MPs) are thiol-specific, reversible bioconjugation reagents for cysteine-specific protein modification, that are commonly used for protein bioconjugation . Br-5MP-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-W591360
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Azide
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Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
|
-
- HY-183740
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|
N-Acryloylindole-alkyne
|
|
Alkynes
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NAIA (N-Acryloylindole-alkyne) is a cysteine-reactive probe. NAIA can be used as an imaging agent, proteome profiling agent, and covalent ligand screening tool .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-140739
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG2000-Maleimide sodium (purity>95%) is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide sodium (purity>95%) can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .
|
-
- HY-W020780C
-
|
mPEG3400-Maleimide
|
|
Polymers
|
|
mPEG3400-Mal is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
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-
- HY-155901
-
|
Maleimide-NH-PEG2000-amine TFA
|
|
Polymers
|
|
Mal-NH-PEG2000-NH2TFA is a PEG derivative that may be used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-140739A
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|
|
Pegylated Lipids
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DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide free acid utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide free acid covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide free acid can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration .
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-
- HY-W020780A
-
|
mPEG350-Maleimide
|
|
Polymers
|
|
mPEG350-Mal is a PEG derivative used for thiol PEGylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
-
- HY-W020780B
-
|
mPEG750-Maleimide
|
|
Polymers
|
|
mPEG750-Mal is a PEG derivative used for thiol pegylation of protein molecules. Its maleimide group (-Mal) degrades in aqueous media and finds application in drug delivery studies.
|
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