5-(2-Chloroacetamide) thalidomide
Based on 1 Customer Validation
5-(2-Chloroacetamide) thalidomide is a Thalidomide (HY-14658) analogue. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. This structure features a chloroacetamide, which is a thiol-specific reactive group.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1957235-51-6
- Formula: C15H12ClN3O5
- Molecular Weight:349.73
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1957235-51-6
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Appearance Solid
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Molecular Weight 349.73
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Formula C15H12ClN3O5
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Color White to off-white
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SMILES
ClCC(NC1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 14.29 mg/mL (40.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8593 mL | 14.2967 mL | 28.5935 mL | 71.4837 mL |
| 5 mM | 0.5719 mL | 2.8593 mL | 5.7187 mL | 14.2967 mL | |
| 10 mM | 0.2859 mL | 1.4297 mL | 2.8593 mL | 7.1484 mL | |
| 15 mM | 0.1906 mL | 0.9531 mL | 1.9062 mL | 4.7656 mL | |
| 20 mM | 0.1430 mL | 0.7148 mL | 1.4297 mL | 3.5742 mL | |
| 25 mM | 0.1144 mL | 0.5719 mL | 1.1437 mL | 2.8593 mL | |
| 30 mM | 0.0953 mL | 0.4766 mL | 0.9531 mL | 2.3828 mL | |
| 40 mM | 0.0715 mL | 0.3574 mL | 0.7148 mL | 1.7871 mL |
5-(2-Chloroacetamide) thalidomide Related Classifications
HY-W674381 Related Classifications
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