2. Metabolic Enzyme/Protease
  3. Herbicide
  4. Terbucarb

Terbucarb is a phenylcarbamate herbicide. Terbucarb disrupts the mitotic microtubule organizing centers in plant cells, leading to the formation of multipolar spindles and branched phragmoplasts, thereby inhibiting plant growth. An "anaphase star" pattern induced by Terbucarb is observed in onion root tips. Terbucarb is cytotoxic to isolated rat hepatocytes, inducing cell death accompanied by depletion of intracellular ATP, protein thiols and glutathione.

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Terbucarb

Terbucarb Chemical Structure

CAS No. : 1918-11-2

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Terbucarb Related Antibodies

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Description

Terbucarb is a phenylcarbamate herbicide. Terbucarb disrupts the mitotic microtubule organizing centers in plant cells, leading to the formation of multipolar spindles and branched phragmoplasts, thereby inhibiting plant growth. An "anaphase star" pattern induced by Terbucarb is observed in onion root tips. Terbucarb is cytotoxic to isolated rat hepatocytes, inducing cell death accompanied by depletion of intracellular ATP, protein thiols and glutathione[1].

In Vitro

Terbucarb (27.7-277 μg/mL; 48 h) significantly induces the formation of micronuclei and multinucleated cells in hamster lung cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Terbucarb Related Antibodies
In Vivo

Terbucarb (1000 mg/kg; p.o.; single dose) does not significantly increase micronucleated reticulocyte frequencies in peripheral blood of male CD-1 mice at 24, 48, or 72 hours post-treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 (male, 8 weeks old, 30 g)[1]
Dosage: 1000 mg/kg
Administration: p.o.; single dose
Result: Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 24 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 3.0 per 1000 reticulocytes at 48 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 72 hours post-treatment.
Demonstrated no statistically significant increase in micronucleated reticulocyte frequencies relative to the concurrent corn oil control group at all time points.
Molecular Weight

277.41

Formula

C17H27NO2
CAS No.
SMILES

O=C(OC=1C(=CC(=CC1C(C)(C)C)C)C(C)(C)C)NC
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Terbucarb Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terbucarb1918-11-2Herbicidemammalian cellsmitotic disrupterbone marrowgenotoxicityphenylcarbamate herbicideonion root tipsCD-1 micestar anaphase figurespolynuclear cellsmicronucleiInhibitorinhibitorinhibit

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