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Cat. No.: HY-W721611

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Terbucarb

Terbucarb is a phenylcarbamate herbicide. Terbucarb disrupts the mitotic microtubule organizing centers in plant cells, leading to the formation of multipolar spindles and branched phragmoplasts, thereby inhibiting plant growth. An "anaphase star" pattern induced by Terbucarb is observed in onion root tips. Terbucarb is cytotoxic to isolated rat hepatocytes, inducing cell death accompanied by depletion of intracellular ATP, protein thiols and glutathione.

For research use only. We do not sell to patients.

CAS No.: 1918-11-2
Formula: C₁₇H₂₇NO₂
Molecular Weight:277.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Terbucarb Chemical Structure

CAS No.: 1918-11-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Terbucarb (27.7-277 μg/mL; 48 h) significantly induces the formation of micronuclei and multinucleated cells in hamster lung cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Terbucarb (1000 mg/kg; p.o.; single dose) does not significantly increase micronucleated reticulocyte frequencies in peripheral blood of male CD-1 mice at 24, 48, or 72 hours post-treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD-1 (male, 8 weeks old, 30 g)^[1]
Dosage:

1000 mg/kg
Administration:

p.o.; single dose
Result:

Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 24 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 3.0 per 1000 reticulocytes at 48 hours post-treatment.
Showed a mean frequency of micronucleated reticulocytes of 1.3 per 1000 reticulocytes at 72 hours post-treatment.
Demonstrated no statistically significant increase in micronucleated reticulocyte frequencies relative to the concurrent corn oil control group at all time points.

Chemical Information

CAS No. 1918-11-2
Molecular Weight 277.41
Formula C₁₇H₂₇NO₂
SMILES

O=C(OC=1C(=CC(=CC1C(C)(C)C)C)C(C)(C)C)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Suzuki T, et al. Micronucleus test of herbicide terbutol and its metabolites in cultured Chinese hamster lung cells and male CD-1 mice. Bull Environ Contam Toxicol. 2000 Jan;64(1):66-73.
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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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