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Cat. No.: HY-N19808

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2-Deacetyl-4-tigloylchamissionolide

2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma.

For research use only. We do not sell to patients.

CAS No.: 173401-52-0
Formula: C₂₀H₂₈O₆
Molecular Weight:364.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-Deacetyl-4-tigloylchamissionolide Chemical Structure

CAS No.: 173401-52-0

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Biological Activity

Description

In Vitro

2-Deacetyl-4-tigloylchamissionolide (compound 20) (2 h; 72 h) exhibits cytotoxicity against murine EN2 cloned Ehrlich ascites tumor cells, with an IC₅₀ of 116 μM after 2 h incubation and 10.4 μM after 72 h incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 173401-52-0
Molecular Weight 364.43
Formula C₂₀H₂₈O₆
SMILES

C[C@@]12[C@@H](C[C@@H]([C@@]1([H])[C@@H](C[C@]3([H])[C@](C(C(O3)=O)=C)([H])[C@@H]2O)C)O)OC(/C(C)=C/C)=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Plants
- Compositae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beekman AC, et al. Structure-cytotoxicity relationships of some helenanolide-type sesquiterpene lactones. J Nat Prod. 1997;60(3):252-257. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2-Deacetyl-4-tigloylchamissionolide

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2-Deacetyl-4-tigloylchamissionolide

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2-Deacetyl-4-tigloylchamissionolide Related Classifications

HY-N19808 Related Classifications