173401-52-0
Chemical Structure
2-Deacetyl-4-tigloylchamissionolide
- CAS No.: 173401-52-0
- Formula:C20H28O6
- Molecular Weight:364.43
InChIKey: WUMRXBPDXGXSJC-JYJHRMTHSA-N
SMILES: C[C@@]12[C@@H](C[C@@H]([C@@]1([H])[C@@H](C[C@]3([H])[C@](C(C(O3)=O)=C)([H])[C@@H]2O)C)O)OC(/C(C)=C/C)=O
Biological Activity: 2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma[1].
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2-Deacetyl-4-tigloylchamissionolide | 2-Deacetyl-4-tigloylchamissionolide is a heliangolide-type sesquiterpene lactone, a derivative of Chamissonolide (HY-N19727), and a cytotoxic agent. 2-Deacetyl-4-tigloylchamissionolide exerts cytotoxicity via alkylating biological nucleophiles, targeting free thiol groups in proteins to interfere with their functions. 2-Deacetyl-4-tigloylchamissionolide exhibits different chromatographic behaviors in TLC and HPLC. 2-Deacetyl-4-tigloylchamissionolide can be used for the research of Ehrlich ascites carcinoma. | |||||||||||||||||||||
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Keywords
