Bis-sulfone NHS ester

Cat. No.: HY-W615327 Purity: 97.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.

For research use only. We do not sell to patients.

Bis-sulfone NHS ester Chemical Structure

CAS No. : 899452-51-8

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
Customer Review

Description

Molecular Weight

597.66

Formula

C₂₉H₂₇NO₉S₂

CAS No.

899452-51-8

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=C(S(=O)(CC(C(C2=CC=C(C(ON3C(CCC3=O)=O)=O)C=C2)=O)CS(=O)(C4=CC=C(C=C4)C)=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (83.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6732 mL	8.3660 mL	16.7319 mL
5 mM	0.3346 mL	1.6732 mL	3.3464 mL
10 mM	0.1673 mL	0.8366 mL	1.6732 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.0%

Select Batch:

Data Sheet (247 KB) SDS (393 KB)

COA (255 KB) HNMR (114 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6732 mL	8.3660 mL	16.7319 mL	41.8298 mL
	5 mM	0.3346 mL	1.6732 mL	3.3464 mL	8.3660 mL
	10 mM	0.1673 mL	0.8366 mL	1.6732 mL	4.1830 mL
	15 mM	0.1115 mL	0.5577 mL	1.1155 mL	2.7887 mL
	20 mM	0.0837 mL	0.4183 mL	0.8366 mL	2.0915 mL
	25 mM	0.0669 mL	0.3346 mL	0.6693 mL	1.6732 mL
	30 mM	0.0558 mL	0.2789 mL	0.5577 mL	1.3943 mL
	40 mM	0.0418 mL	0.2091 mL	0.4183 mL	1.0457 mL
	50 mM	0.0335 mL	0.1673 mL	0.3346 mL	0.8366 mL
	60 mM	0.0279 mL	0.1394 mL	0.2789 mL	0.6972 mL
	80 mM	0.0209 mL	0.1046 mL	0.2091 mL	0.5229 mL