899452-51-8

Bis-sulfone NHS ester Chemical Structure
899452-51-8

Chemical Structure

Bis-sulfone NHS ester

  • CAS No.: 899452-51-8
  • Formula:C29H27NO9S2
  • Molecular Weight:597.66

IUPAC Name: 2,5-dioxopyrrolidin-1-yl 4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoate

InChIKey: NTRPBIATANVSPI-UHFFFAOYSA-N

SMILES: CC1=CC=C(S(=O)(CC(C(C2=CC=C(C(ON3C(CCC3=O)=O)=O)C=C2)=O)CS(=O)(C4=CC=C(C=C4)C)=O)=O)C=C1

Biological Activity: Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.

Cat. No. 상품명 Purity 제품 설명 Pricing
HY-W615327 		Bis-sulfone NHS ester 97.0% Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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