4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Synonyms: Bis–sulfone Acid)

Cat. No.: HY-W073382 Purity: 97.76%: Data Sheet
COA

SDS
Handling Instructions
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4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid 화학구조

CAS No. : 124243-00-1

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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제품 설명

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups.

In Vitro

Each tosyl group in 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

500.58

화학식

C₂₅H₂₄O₇S₂

CAS No.

124243-00-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)C(O)=O)C(CS(=O)(C2=CC=C(C=C2)C)=O)CS(=O)(C3=CC=C(C=C3)C)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : 100 mg/mL (199.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9977 mL	9.9884 mL	19.9768 mL
5 mM	0.3995 mL	1.9977 mL	3.9954 mL
10 mM	0.1998 mL	0.9988 mL	1.9977 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 97.76%

Select Batch:

Data Sheet (247 KB) SDS (393 KB)

COA (253 KB) HNMR (114 KB) RP-HPLC (248 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9977 mL	9.9884 mL	19.9768 mL	49.9421 mL
	5 mM	0.3995 mL	1.9977 mL	3.9954 mL	9.9884 mL
	10 mM	0.1998 mL	0.9988 mL	1.9977 mL	4.9942 mL
	15 mM	0.1332 mL	0.6659 mL	1.3318 mL	3.3295 mL
	20 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4971 mL
	25 mM	0.0799 mL	0.3995 mL	0.7991 mL	1.9977 mL
	30 mM	0.0666 mL	0.3329 mL	0.6659 mL	1.6647 mL
	40 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2486 mL
	50 mM	0.0400 mL	0.1998 mL	0.3995 mL	0.9988 mL
	60 mM	0.0333 mL	0.1665 mL	0.3329 mL	0.8324 mL
	80 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL
	100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.4994 mL

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid124243-00-1Bis–sulfone AcidBiochemical Assay ReagentsBiochemical Assay ReagentInhibitorinhibitorinhibit

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4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Synonyms: Bis–sulfone Acid)

4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid Related Antibodies

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