Bis-sulfone-PEG3-Azide
Based on 1 Customer Validation
Bis-sulfone-PEG3-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-sulfone-PEG3-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 97.77%
- CAS No.: 1802908-01-5
- Formula: C33H40N4O9S2
- Molecular Weight:700.82
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1802908-01-5
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Appearance Liquid
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Molecular Weight 700.82
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Formula C33H40N4O9S2
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Color Colorless to light yellow
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SMILES
O=C(NCCOCCOCCOCCN=[N+]=[N-])C1=CC=C(C(C(CS(=O)(C2=CC=C(C)C=C2)=O)CS(=O)(C3=CC=C(C)C=C3)=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (71.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (240 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4269 mL | 7.1345 mL | 14.2690 mL | 35.6725 mL |
| 5 mM | 0.2854 mL | 1.4269 mL | 2.8538 mL | 7.1345 mL | |
| 10 mM | 0.1427 mL | 0.7134 mL | 1.4269 mL | 3.5672 mL | |
| 15 mM | 0.0951 mL | 0.4756 mL | 0.9513 mL | 2.3782 mL | |
| 20 mM | 0.0713 mL | 0.3567 mL | 0.7134 mL | 1.7836 mL | |
| 25 mM | 0.0571 mL | 0.2854 mL | 0.5708 mL | 1.4269 mL | |
| 30 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1891 mL | |
| 40 mM | 0.0357 mL | 0.1784 mL | 0.3567 mL | 0.8918 mL | |
| 50 mM | 0.0285 mL | 0.1427 mL | 0.2854 mL | 0.7134 mL | |
| 60 mM | 0.0238 mL | 0.1189 mL | 0.2378 mL | 0.5945 mL |
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