Bis-sulfone-PEG3-Azide

Cat. No.: HY-138745: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Bis-sulfone-PEG3-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-sulfone-PEG3-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Bis-sulfone-PEG3-Azide Chemical Structure

CAS No. : 1802908-01-5

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5 mg	USD 320	Ask For Quote & Lead Time

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Biological Activity
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Description

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

700.82

Formula

C₃₃H₄₀N₄O₉S₂

CAS No.

1802908-01-5

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(NCCOCCOCCOCCN=[N+]=[N-])C1=CC=C(C(C(CS(=O)(C2=CC=C(C)C=C2)=O)CS(=O)(C3=CC=C(C)C=C3)=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (71.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4269 mL	7.1345 mL	14.2690 mL
5 mM	0.2854 mL	1.4269 mL	2.8538 mL
10 mM	0.1427 mL	0.7134 mL	1.4269 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.00%

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Data Sheet (240 KB) SDS (0 KB)

COA (245 KB) HNMR (125 KB) RP-HPLC (398 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4269 mL	7.1345 mL	14.2690 mL	35.6725 mL
	5 mM	0.2854 mL	1.4269 mL	2.8538 mL	7.1345 mL
	10 mM	0.1427 mL	0.7134 mL	1.4269 mL	3.5672 mL
	15 mM	0.0951 mL	0.4756 mL	0.9513 mL	2.3782 mL
	20 mM	0.0713 mL	0.3567 mL	0.7134 mL	1.7836 mL
	25 mM	0.0571 mL	0.2854 mL	0.5708 mL	1.4269 mL
	30 mM	0.0476 mL	0.2378 mL	0.4756 mL	1.1891 mL
	40 mM	0.0357 mL	0.1784 mL	0.3567 mL	0.8918 mL
	50 mM	0.0285 mL	0.1427 mL	0.2854 mL	0.7134 mL
	60 mM	0.0238 mL	0.1189 mL	0.2378 mL	0.5945 mL