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Cat. No.: HY-W1048851B

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4-Arm-PEG10000-Maleimide

(Synonyms: 4-Arm-PEG10000-Mal)

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Based on 1 Customer Validation

4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation.

For research use only. We do not sell to patients.

Purity: 97.0%
CAS No.: 1349099-55-3
Formula: (C₂H₄O)n(C₂H₄O)n(C₂H₄O)n(C₂H₄O)nC₄₁H₅₂N₈O₁₆
Molecular Weight:10000 (Average)

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

4-Arm-PEG10000-Maleimide Chemical Structure

CAS No.: 1349099-55-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

4-Arm-PEG10000-Maleimide (72 h) exerts no cytotoxic effects on GD2-positive B78-D14 or GD2-negative B16 mouse melanoma cells^[1].
As a crosslinker, 4-Arm-PEG10000-Maleimide forms an insoluble gel with spirothienopyran-functionalized methacrylate-PEG copolymer under UV irradiation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

GD2-positive B78-D14 mouse melanoma cells, GD2-negative B16 mouse melanoma cells
Concentration:

Up to 370 nM (scFv molarity, for scFv-4-Arm-PEG-Maleimide conjugates)
Incubation Time:

72 h
Result:

Induced no cytotoxic effect on the viability of either GD2-positive B78-D14 or GD2-negative B16 mouse melanoma cells.

Chemical Information

CAS No. 1349099-55-3
Appearance Solid
Molecular Weight 10000 (Average)
Formula (C₂H₄O)n(C₂H₄O)n(C₂H₄O)n(C₂H₄O)nC₄₁H₅₂N₈O₁₆
Color White to off-white
SMILES

O=C(CCN1C(C=CC1=O)=O)NCCOCCOCC(COCCOCCNC(CCN2C(C=CC2=O)=O)=O)(COCCOCCNC(CCN3C(C=CC3=O)=O)=O)COCCOCCNC(CCN4C(C=CC4=O)=O)=O.[n].[n].[n].[n]
Synonyms

4-Arm-PEG10000-Mal
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kalinovsky DV, et al. Targeting GD2-Positive Tumor Cells by Pegylated scFv Fragment-Drug Conjugates Carrying Maytansinoids DM1 and DM4. Curr Issues Mol Biol. 2023;45(10):8112-8125. Published 2023 Oct 5. [Content Brief]

[2]. Vijayamohanan H, et al. Spirothiopyran-based reversibly saturable photoresist. Chemistry of Materials. 2017 Jun 13;29(11):4754-60.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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