MTSSL (Synonyms: Otmpmms)

製品番号: HY-130509 純度: 99%: Data Sheet SDS COA 取扱説明書
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MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

MTSSL 構造式

CAS 番号 : 81213-52-7

容量	価格（税別）	在庫状況	数量
5 mg	$145	在庫あり	Estimated Time of Arrival: December 31
10 mg	$260	在庫あり	Estimated Time of Arrival: December 31
25 mg	$515	在庫あり	Estimated Time of Arrival: December 31
50 mg	$925	お問い合わせ
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of MTSSL:

MTSSLMTSSL-¹⁵N お問い合わせ
MTSSL-¹⁵N,d₁₅ お問い合わせ

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純度とドキュメンテーション
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製品説明

MTSSL (Otmpmms) is highly reactive thiol-specific spin label, which is used to label protein thiol residues for protein structure and dynamics determination and protein-protein interaction studies^[1].

分子量

264.38

分子式

C₁₀H₁₈NO₃S₂

CAS 番号

81213-52-7

Appearance

Solid

Color

Off-white to light yellow

SMILES

[O]N1C(C)(C)C(CSS(=O)(C)=O)=CC1(C)C

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (378.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7824 mL	18.9122 mL	37.8243 mL
5 mM	0.7565 mL	3.7824 mL	7.5649 mL
10 mM	0.3782 mL	1.8912 mL	3.7824 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (9.46 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99%

Select Batch:

データシート (275 KB) SDS (394 KB)

COA (253 KB) Elemental Analysis Report (111 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Watanabe Y, et al., Identification of pH-sensitive regions in the mouse prion by the cysteine-scanning spin-labeling ESR technique. Biochem Biophys Res Commun. 2006 Nov 24;350(3):549-56. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7824 mL	18.9122 mL	37.8243 mL	94.5609 mL
	5 mM	0.7565 mL	3.7824 mL	7.5649 mL	18.9122 mL
	10 mM	0.3782 mL	1.8912 mL	3.7824 mL	9.4561 mL
	15 mM	0.2522 mL	1.2608 mL	2.5216 mL	6.3041 mL
	20 mM	0.1891 mL	0.9456 mL	1.8912 mL	4.7280 mL
	25 mM	0.1513 mL	0.7565 mL	1.5130 mL	3.7824 mL
	30 mM	0.1261 mL	0.6304 mL	1.2608 mL	3.1520 mL
	40 mM	0.0946 mL	0.4728 mL	0.9456 mL	2.3640 mL
	50 mM	0.0756 mL	0.3782 mL	0.7565 mL	1.8912 mL
	60 mM	0.0630 mL	0.3152 mL	0.6304 mL	1.5760 mL
	80 mM	0.0473 mL	0.2364 mL	0.4728 mL	1.1820 mL
	100 mM	0.0378 mL	0.1891 mL	0.3782 mL	0.9456 mL

MTSSL Related Classifications

Others

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTSSL81213-52-7OtmpmmsBiochemical Assay Reagentselectron spin resonanceESRsite-directed spin labelingSDSLNMRInhibitorinhibitorinhibit

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