NAIA
NAIA (N-Acryloylindole-alkyne) is a cysteine-reactive probe. NAIA can be used as an imaging agent, proteome profiling agent, and covalent ligand screening tool.
For research use only. We do not sell to patients.
- CAS No.: 3020685-33-7
- Formula: C19H20N2O3
- Molecular Weight:324.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NAIA enables proteome-wide identification of functional cysteines in HepG2 cell lysates via MS-based ABPP[2].
NAIA enables functional cysteine profiling in live cells and cancer cell lysates[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3020685-33-7
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Molecular Weight 324.37
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Formula C19H20N2O3
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SMILES
O=C(N1C=CC2=C1C=CC(OCC(NCCCCC#C)=O)=C2)C=C
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Synonyms
N-Acryloylindole-alkyne
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Koo TY, et al. N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. [Content Brief]
[2]. Koo TY, et al. Activity-Based Protein Profiling for Functional Cysteines and Protein Target Identification. Methods Mol Biol. 2025;2921:331-344. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NAIA Related Classifications
HY-183740 Related Classifications
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