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Results for "

vaccinia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	VRK (1) 11β-HSD (1) Akt (1) Antibiotic (5) Apoptosis (1) Arenavirus (3) Autophagy (1) Bacterial (4) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (1) CHIKV (1) CMV (4) DNA Methyltransferase (1) DNA/RNA Synthesis (9) Drug Metabolite (2) EGFR (4) Endogenous Metabolite (5) Enterovirus (1) Flavivirus (1) GABA Receptor (1) Gap Junction Protein (1) Glucocorticoid Receptor (1) HIV (2) HPV (2) HSV (6) IFNAR (3) Influenza Virus (1) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (2) NO Synthase (2) Nucleoside Antimetabolite/Analog (2) Orthopoxvirus (29) Parasite (1) Phosphatase (9) Potassium Channel (1) Reference Standards (7) SARS-CoV (1) STING (2) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Infection (42) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (4)
Oligonucleotides:	Nucleotide Analogs (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: VRK

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-B1367

Carbenoxolone disodium 5+ Cited Publications	Gap Junction Protein Orthopoxvirus 11β-HSD	Infection Inflammation/Immunology
Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD . Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication . Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.

HY-14805

Tecovirimat 1 Publications Verification ST-246	Orthopoxvirus Arenavirus	Infection
Tecovirimat (ST-246) is an orally bioavailable and selective compound against orthopoxviruses including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC₅₀ values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus .

HY-B0125

Ofloxacin 10+ Cited Publications Hoe-280	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection Cancer
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-10367

Canertinib 5+ Cited Publications CI-1033; PD-183805	EGFR Orthopoxvirus	Infection Cancer
Canertinib (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC₅₀s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice .

HY-12836A

IFN alpha-IFNAR-IN-1 hydrochloride Maximum Cited Publications 25 Publications Verification	IFNAR	Inflammation/Immunology
IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC₅₀=2-8 μM) .

HY-126542

VRK-IN-1 5 Publications Verification	VRK	Neurological Disease
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC₅₀ of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders .

HY-W091784

3'-O-Methylguanosine	Endogenous Metabolite Orthopoxvirus Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Infection
3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA .

HY-10367A

Canertinib dihydrochloride 5+ Cited Publications CI-1033 dihydrochloride; PD-183805 dihydrochloride	EGFR Orthopoxvirus	Infection Cancer
Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC₅₀s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice .

HY-N0093

Ancitabine hydrochloride 1 Publications Verification Cyclocytidine hydrochloride; Cyclo-CMP hydrochloride; Cyclo-C	Autophagy CMV DNA/RNA Synthesis	Infection Cancer
Ancitabine hydrochloride is a cytarabine derivative that inhibits viral replication. Ancitabine hydrochloride blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine hydrochloride is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer .

HY-101997

BEPP hydrochloride	Orthopoxvirus Apoptosis Caspase Bcl-2 Family Akt	Infection Cancer
BEPP hydrochloride is a double-stranded RNA-dependent protein kinase (PKR) modulator. BEPP hydrochloride enhances the phosphorylation levels of PKR and eIF2α, activates caspase-3, upregulates the pro-apoptotic protein BAX, and downregulates the anti-apoptotic protein Bcl-2. BEPP hydrochloride inhibits vaccinia virus replication and exhibits selective cytotoxicity in cells expressing PKR. BEPP hydrochloride can be used in research related to cancer and viral infections .

HY-B0502A

Enrofloxacin monohydrochloride 15+ Cited Publications BAY Vp 2674 monohydrochloride; PD160788 monohydrochloride	Bacterial Antibiotic Orthopoxvirus	Infection
Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC₉₀ of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

HY-107801

Inosine pranobex 1 Publications Verification Imunovir; Delimmun; Groprinosin	Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

HY-131606B

Cidofovir diphosphate tritriethylamine	Drug Metabolite DNA/RNA Synthesis	Infection
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-141567A

Pseudouridine 5'-triphosphate trisodium solution (100 mM) 1 Publications Verification Pseudo-UTP trisodium solution (100 mM)	DNA/RNA Synthesis	Infection
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection .

HY-W291131

Isatin-β-thiosemicarbazone IBT	HSV Orthopoxvirus	Infection
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits

HY-175636

ITGB3-IN-1	Integrin Orthopoxvirus Potassium Channel	Infection
ITGB3-IN-1 is an orally active integrin subunit beta 3 ITGB3 inhibitor with a K_d of 7.26 μM. ITGB3-IN-1 exhibits potent anti-orthopoxvirus effects with an EC₅₀ for vaccinia virus (VACV) of 1.82 μM. ITGB3-IN-1 inhibits hERG with an IC₅₀ of 1.13 μM. ITGB3-IN-1 can be used for the study of orthopoxvirus .

HY-130430

Neplanocin A (-)-Neplanocin A	Antibiotic Orthopoxvirus	Infection Cancer
Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (K_i=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis .

HY-W012738

DL-Pyroglutamic acid 1 Publications Verification	Influenza Virus GABA Receptor	Infection
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action .

HY-160224

dsVACV-70mer sodium	STING IFNAR	Inflammation/Immunology
dsVACV-70mer (sodium) is a 70 bp double-stranded oligonucleotide containing viral DNA motifs derived from vaccinia virus DNA. dsVACV-70mer (sodium) has potently induces IFN-β via a STING-dependent manner .

HY-141567

Pseudouridine 5'-triphosphate Pseudo-UTP	DNA/RNA Synthesis	Infection
Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection .

HY-14805A

Tecovirimat monohydrate 1 Publications Verification ST-246 monohydrate	Orthopoxvirus Arenavirus	Infection
Tecovirimat (ST-246) monohydrate is the monohydrate form of Tecovirimat (HY-14805). Tecovirimat monohydrate is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat monohydrate is evaluated against vaccinia, cowpox virus, ectromelia virus with EC₅₀ values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat monohydrate targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat monohydrate exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat monohydrate could be used in the study for orthopoxvirus-induced diseases .

HY-W007524

2-Aminoquinoline 1 Publications Verification 2-Quinolinamine	NO Synthase Orthopoxvirus	Infection Neurological Disease
2-Aminoquinoline (2-Quinolinamine) is a promising compound as bioavailable nNOS inhibitor but suffers from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets. 2-Aminoquinoline exhibits antiviral activity against the vaccinia virus. 2-Aminoquinoline has the potential for the research of antineurodegenerative agents .

HY-12836

IFN alpha-IFNAR-IN-1 Maximum Cited Publications 25 Publications Verification	IFNAR	Inflammation/Immunology
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC₅₀=2-8 μM) .

HY-B0125R

Ofloxacin (Standard) Hoe-280 (Standard)	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-131606

Cidofovir diphosphate	HSV CMV DNA/RNA Synthesis	Infection
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-107949

Flumethasone pivalate Flumethasone 21-pivalate	Glucocorticoid Receptor	Cardiovascular Disease Inflammation/Immunology
Flumethasone pivalate (Flumethasone 21-pivalate) is a glucocorticoid and a topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive actions. Flumethasone pivalate inhibits foreign body granuloma formation. Flumethasone pivalate can be used for the researches of dermatitis, eczema, and psoriasis .

HY-P990265

Anti-Mouse CD69 Antibody (CD69.2.2)	Transmembrane Glycoprotein Orthopoxvirus	Infection Others Inflammation/Immunology Cancer
Anti-Mouse CD69 Antibody (CD69.2.2) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD69. Anti-Mouse CD69 Antibody (CD69.2.2) causes CD69 to be internalized but does not deplete CD69 ⁺ cells. Anti-Mouse CD69 Antibody (CD69.2.2) can be used for the researches of cancer, infection, inflammation and immunology, such as RMA-S tumor, arthritis and vaccinia virus (VACV) infection .

HY-14805S

Tecovirimat-d4 ST-246-d₄	Isotope-Labeled Compounds Orthopoxvirus Arenavirus	Infection
Tecovirimat-d₄ (ST-246-d₄) is a deuterium-labelled Tecovirimat (HY-14805). Tecovirimat is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC₅₀ values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat could be used in the study for orthopoxvirus-induced diseases .

HY-147014

Cyclic HPMPC	CMV Orthopoxvirus	Infection
Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model .

HY-178285

VHR-IN-2	Phosphatase	Cancer
VHR-IN-2 (Compound SA9) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC₅₀ of 3.1 μM. VHR-IN-2 can be used for the research of cervical cancer .

HY-178294

VHR-IN-4	Phosphatase	Cancer
VHR-IN-4 (Compound SA7) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC₅₀ of 1.8 μM. VHR-IN-4 can be used for the research of cervical cancer .

HY-178449

Orthopoxviruses-IN-1	Orthopoxvirus	Infection
Orthopoxviruses-IN-1 (Compound 4) is a potent p37 protein inhibitor (IC₅₀= 0.017 µM against Vaccinia virus (VACV)). Orthopoxviruses-IN-1 is promising for research of orthopoxvirus-related diseases, including variola virus (smallpox) and monkeypox .

HY-178292

VHR-IN-3	Phosphatase	Cancer
VHR-IN-3 (Compound 1) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with a K_i of 0.81 μM. VHR-IN-3 mimics the phosphate group through the sulfonic acid group and competitively binds to the catalytic active center of VHR. VHR-IN-3 can be used for the research of cervical cancer .

HY-W091784R

3'-O-Methylguanosine (Standard)	Reference Standards Endogenous Metabolite Orthopoxvirus Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Infection
3'-O-Methylguanosine (Standard) is an analytical standard of 3'-O-Methylguanosine (HY-W091784). This product is intended for research and analytical applications. 3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA .

HY-W007524R

2-Aminoquinoline (Standard) 2-Quinolinamine (Standard)	Reference Standards NO Synthase Orthopoxvirus	Infection Neurological Disease
2-Aminoquinoline (2-Quinolinamine) is a promising compound as bioavailable nNOS inhibitor but suffers from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets. 2-Aminoquinoline exhibits antiviral activity against the vaccinia virus. 2-Aminoquinoline has the potential for the research of antineurodegenerative agents .

HY-149022

HSV-1/HSV-2-IN-1	HSV Orthopoxvirus	Infection
HSV-1/HSV-2-IN-1 (compound 7d) is a HSV-1 and HSV-2 inhibitor, with EC₅₀s of 7.6, 7.6, 4, and 12 μM for HSV-1 (KOS), HSV-2 (G), HSV-1 TK ^- KOS ACV ^r and vaccinia virus in human embryonic lung fibroblast cell cultures .

HY-107801R

Inosine pranobex (Standard) Imunovir (Standard); Delimmun (Standard); Groprinosin (Standard); (Standard)	Reference Standards Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex (Standard) is the analytical standard of Inosine pranobex. This product is intended for research and analytical applications. Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

HY-131606S

Cidofovir diphosphate-13C3	Isotope-Labeled Compounds Orthopoxvirus Drug Metabolite CMV DNA/RNA Synthesis	Infection
Cidofovir diphosphate- ¹³C₃ is the ¹³C-labeled Cidofovir diphosphate (HY-131606). Cidofovir diphosphate is the intracellular active metabolite of Cidofovir (HY-17438) and its oral prodrug Brincidofovir (HY-14532). By inhibiting viral DNA polymerase (Ki ≈ 76.3 μM), cidofovir diphosphate is widely used in studies on double-stranded DNA virus infections, including cytomegalovirus (CMV), adenovirus (AdV), and poxviruses (such as monkeypox and molluscum contagiosum virus, MCV) .

HY-178297

VHR-IN-7	Phosphatase	Cancer
VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC₅₀ of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC₅₀ = 0.47 μM), CD45 (IC₅₀ = 0.3 μM), Cdc25A (IC₅₀ = 3.4 μM), PTP1B (IC₅₀ = 0.59 μM), and HePTP (IC₅₀ = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer .

HY-178296

VHR-IN-6	Phosphatase	Cancer
VHR-IN-6 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC₅₀ of 74 nM. VHR-IN-6 shows very weaker inhibitory activity against MKP-1 (IC₅₀ = 0.52 μM), CD45 (IC₅₀ = 0.50 μM), Cdc25A (IC₅₀ = 2.8 μM), PTP1B (IC₅₀ = 0.42 μM), and HePTP (IC₅₀ = 0.87 μM). VHR-IN-6 inhibits the proliferation of HeLa cells. VHR-IN-6 can be used for the research of cervical cancer .

HY-178301

VHR-IN-9	Phosphatase	Cancer
VHR-IN-9 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC₅₀ of 270 nM. VHR-IN-9 shows very weaker inhibitory activity against MKP-1 (IC₅₀ = 2.8 μM), CD45 (IC₅₀ = 1.8 μM), Cdc25A (IC₅₀ = > 10 μM), PTP1B (IC₅₀ = 2.2 μM), and HePTP (IC₅₀ = 2.4 μM). VHR-IN-9 inhibits the proliferation of HeLa cells. VHR-IN-9 can be used for the research of cervical cancer .

HY-E70080

Vaccinia virus capping enzyme	Biochemical Assay Reagents	Others
Vaccinia virus capping enzyme is a transcription initiation factor. Vaccinia virus capping enzyme is a heterodimer of D1 (844 aa) and D12 (287 aa) polypeptides that executes all three steps in m7GpppRNA synthesis. Vaccinia virus capping enzyme has been used widely as a reagent for capping and cap-labeling RNAs in vitro .

HY-147371

Quinoprazine	Parasite	Infection Neurological Disease
Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC₅₀ value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrP ^{S ^c} levels ^- .

HY-178303

VHR-IN-8	Phosphatase	Cancer
VHR-IN-8 (Compound SA8) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC₅₀ of 2.4 μM. VHR-IN-8 can be used for the research of cervical cancer .

HY-N14446

Karalicin	HSV	Infection
Karalicin inhibits herpes simplex virus HSV-1, HSV-2, vaccinia virus, polio virus type I with the IC₅₀s (μg/mL) of 0.004, 0.008, 0.016 and 0.016 .

HY-160223

ssVACV-70mer sodium	STING	Infection Inflammation/Immunology
ssVACV-70mer sodium is a 70 bp single-stranded oligonucleotide containing viral DNA motifs that derive from the vaccinia virus DNA. Unlike its double-stranded counterpart dsVACV 70mer, ssVACV 70mer is not IFN-inducer .

HY-B0502AR

Enrofloxacin monohydrochloride (Standard) BAY Vp 2674 monohydrochloride (Standard); PD160788 monohydrochloride (Standard)	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection
Enrofloxacin (monohydrochloride) (Standard) is the analytical standard of Enrofloxacin (monohydrochloride). This product is intended for research and analytical applications. Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

HY-10367AR

Canertinib dihydrochloride (Standard) CI-1033 dihydrochloride (Standard); PD-183805 dihydrochloride (Standard)	Reference Standards EGFR Orthopoxvirus	Infection Cancer
Canertinib (dihydrochloride) (Standard) is the analytical standard of Canertinib (dihydrochloride). This product is intended for research and analytical applications. Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice .

HY-10367R

Canertinib (Standard) CI-1033 (Standard); PD-183805 (Standard)	Reference Standards EGFR Orthopoxvirus	Infection Cancer
Canertinib (Standard) is the analytical standard of Canertinib. This product is intended for research and analytical applications. Canertinib (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice .

HY-178295

VHR-IN-5	Phosphatase	Cancer
VHR-IN-5 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC₅₀ of 78 nM. VHR-IN-5 shows very weaker inhibitory activity against MKP-1 (IC₅₀ = 0.78 μM), CD45 (IC₅₀ = 0.61 μM), Cdc25A (IC₅₀ = 3.4 μM), PTP1B (IC₅₀ = 1.8 μM), and HePTP (IC₅₀ = 1.5 μM). VHR-IN-5 inhibits the proliferation of HeLa cells. VHR-IN-5 can be used for the research of cervical cancer .

Cat. No.	상품명

HY-L127

Anti-Orthopoxvirus Compound Library

37 compounds

Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. The orthopoxvirus genus consists of 12 viruses including variola virus, vaccinia virus (VV), cowpox viruses (CV), monkeypox virus, and camelpox virus. Smallpox has been eradicated worldwide in 1980, but some other orthopoxvirus, such as monkeypox virus, are still threats to human health.

There are not many drugs available for orthopoxvirus treatment. The only product currently available for treatment of complications of Orthopoxvirus infection is vaccinia immunoglobulin (VIG). In 2021, brincidofovir was approved by FDA for the treatment of smallpox and tecovirimat was approved by EMA for the treatment of monkeypox in 2022. A few active compounds including interferon and interferon inducers, and a variety of nucleosides or nucleotides have been reported to have activity against orthopoxvirus.

MCE carefully prepared a unique collection of 37 compounds reported with the anti- orthopoxvirus activity which can be used for drug screening and other research about orthopoxvirus.

Cat. No.	상품명	Type

HY-141567A

Pseudouridine 5'-triphosphate trisodium solution (100 mM)

1 Publications Verification

Pseudo-UTP trisodium solution (100 mM)

Biochemical Assay Reagents

Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection .

HY-141567

Pseudouridine 5'-triphosphate

Pseudo-UTP

Biochemical Assay Reagents

Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection .

Cat. No.	상품명	Target	Research Area

HY-P5364

B8R 20-27	Peptides	Others
B8R 20-27 is a biological active peptide. (This is amino acids 20 to 27 fragment of B8R, a vaccinia virus (VV) gene that encodes a secreted protein related to gamma interferon receptor. B8R binding to IFN-g neutralizes its antiviral activity.)

HY-106187B

MART-1 (27-35) (human) TFA		Cancer
MART-1 (27-35) (human) (TFA) is the amino acid fragment spanning positions 27 to 35 of the MART-1 protein, and it represents an immunogenic epitope recognizable by HLA-A2-restricted melanoma-specific tumor-infiltrating lymphocytes (TILs). MART-1 (27-35) (human) (TFA) can be used in studies related to melanoma .

Cat. No.	상품명	Target	Research Area	Image

HY-P990265

Anti-Mouse CD69 Antibody (CD69.2.2)	Transmembrane Glycoprotein Orthopoxvirus	Infection Others Inflammation/Immunology Cancer
Anti-Mouse CD69 Antibody (CD69.2.2) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD69. Anti-Mouse CD69 Antibody (CD69.2.2) causes CD69 to be internalized but does not deplete CD69 ⁺ cells. Anti-Mouse CD69 Antibody (CD69.2.2) can be used for the researches of cancer, infection, inflammation and immunology, such as RMA-S tumor, arthritis and vaccinia virus (VACV) infection .

HY-P992081

Anti-H3L Antibody (NAL_A185)	Orthopoxvirus	Infection
Anti-H3L Antibody (NAL_A185) is a neutralizing antibody targeting the H3L envelope protein of vaccinia virus (CV) belonging to the genus Orthopoxvirus. By binding to the H3L protein of intracellular mature virions, Anti-H3L Antibody (NAL_A185) blocks the binding of the virus to host cells, thereby neutralizing viral infectivity. Anti-H3L Antibody (NAL_A185) not only protects BALB/c mice from intranasal challenge with the lethal vaccinia virus WR strain, reducing weight loss and mortality, but also exhibits complement-dependent neutralizing activity against monkeypox virus. Among these properties, NAL_A185 is an immune target induced by the smallpox vaccine Dryvax; it elicits a robust recall antibody response and induces high-titer neutralizing antibodies in mice. Anti-H3L Antibody (NAL_A185) can be used for studies related to vaccinia virus infection, monkeypox and monkeypox disease .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-B0125

Ofloxacin 10+ Cited Publications Hoe-280	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-W091784

3'-O-Methylguanosine	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Orthopoxvirus Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA .

HY-N0093

Ancitabine hydrochloride 1 Publications Verification Cyclocytidine hydrochloride; Cyclo-CMP hydrochloride; Cyclo-C	Classification of Application Fields Disease Research Fields Cancer	Autophagy CMV DNA/RNA Synthesis
Ancitabine hydrochloride is a cytarabine derivative that inhibits viral replication. Ancitabine hydrochloride blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine hydrochloride is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer .

HY-130430

Neplanocin A (-)-Neplanocin A	Natural Products Microorganisms Source Classification	Antibiotic Orthopoxvirus
Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (K_i=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis .

HY-B0125R

Ofloxacin (Standard) Hoe-280 (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-W091784R

3'-O-Methylguanosine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Orthopoxvirus Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
3'-O-Methylguanosine (Standard) is an analytical standard of 3'-O-Methylguanosine (HY-W091784). This product is intended for research and analytical applications. 3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA .

HY-N14446

Karalicin	Natural Products Microorganisms Source Classification	HSV
Karalicin inhibits herpes simplex virus HSV-1, HSV-2, vaccinia virus, polio virus type I with the IC₅₀s (μg/mL) of 0.004, 0.008, 0.016 and 0.016 .

HY-B0502AR

Enrofloxacin monohydrochloride (Standard) BAY Vp 2674 monohydrochloride (Standard); PD160788 monohydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Enrofloxacin (monohydrochloride) (Standard) is the analytical standard of Enrofloxacin (monohydrochloride). This product is intended for research and analytical applications. Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

Species:	Virus (3) Human (13)
Tag:	His (14) Tag Free (2) Avi (7) Myc (2) GST (3)
Source:	HEK293 (8) Sf9 insect cells (7) E. coli (1)

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HY-P705339

	*HLA-A02:01&B2M&Vaccinia Virus(ILDDNLYKV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & vaccinia* virus (ILDDNLYKV)	Human	HEK293

HY-P705340

	*HLA-A02:01&B2M&Vaccinia Virus(ILYDNVVTL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & vaccinia* virus (ILYDNVVTL)	Human	HEK293

HY-P705341

	*HLA-A02:01&B2M&Vaccinia Virus(IMYDIINSV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & vaccinia* virus (IMYDIINSV)	Human	HEK293

HY-P705342

	*HLA-A02:01&B2M&Vaccinia Virus(LLSYYVVYV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & vaccinia* virus (LLSYYVVYV)	Human	HEK293

HY-P705343

	*HLA-A02:01&B2M&Vaccinia Virus(SLSNLDFRL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & vaccinia* virus (SLSNLDFRL)	Human	HEK293

HY-P705344

	*HLA-A02:01&B2M&Vaccinia Virus(VLYNGVNYL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & vaccinia* virus (VLYNGVNYL)	Human	HEK293

HY-P705345

	*HLA-A02:01&B2M&Vaccinia Virus(YLAKLTALV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A0201 & B2M & vaccinia* virus (YLAKLTALV)	Human	HEK293

HY-P72300

	*Protein L1/VACWR088, Vaccinia* virus (sf9, His, myc)** Virion membrane protein M25	Virus	Sf9 insect cells
	Protein L1/VACWR088 is a crucial part of the entry fusion complex (EFC) comprising 11 proteins. It facilitates the entry of the virion core into the host cytoplasm through a two-step process involving lipid mixing and pore formation. All EFC proteins, except OPG095/L1 and OPG053/F9, contribute to the assembly or stability of the complex. Protein L1/VACWR088, Vaccinia virus (sf9, His, myc) is the recombinant Virus-derived protein L1/VACWR088, expressed by sf9 insect cells , with N-His, C-Myc labeled tag.

HY-P72301

	*Protein L1/L1R, Vaccinia* virus (sf9, His, myc)** 1 Publications Verification Virion membrane protein M25	Virus	Sf9 insect cells
	Protein L1/L1R is part of the entry fusion complex (EFC) composed of 11 proteins. This complex facilitates the entry of the virion core into the host cytoplasm through a two-step process: lipid mixing of viral and cellular membranes, followed by pore formation. The assembly or stability of the EFC relies on all proteins except OPG095 and OPG053. Protein L1/L1R, Vaccinia virus (sf9, His, myc) is the recombinant Virus-derived protein L1/L1R, expressed by sf9 insect cells , with N-His, C-Myc labeled tag.

HY-P77504

	VRK1 Protein, Human (sf9) Serine/threonine-protein kinase VRK1; vaccinia-related kinase 1; VRK1	Human	Sf9 insect cells
	The VRK1 protein is a serine/threonine kinase that complexly regulates the cell cycle, nuclear condensation, and transcription. It critically induces Golgi disassembly during the cell cycle via PLK3 phosphorylation, thereby affecting Golgi fragmentation. VRK1 Protein, Human (sf9) is the recombinant human-derived VRK1 protein, expressed by Sf9 insect cells, with tag free.

HY-P706111

	VRK1 Protein, Human (Active, sf9, His-GST) Serine/threonine-protein kinase VRK1; vaccinia-related kinase 1	Human	Sf9 insect cells

HY-P706112

	VRK2 Protein, Human (Active, sf9, His-GST) Serine/threonine-protein kinase VRK2; vaccinia-related kinase 2	Human	Sf9 insect cells

HY-P71150

	DUSP3 Protein, Human (His) Dual specificity protein phosphatase 3; DUSP3; Dual specificity protein phosphatase VHR; vaccinia H1-related phosphatase; VHR	Human	E. coli
	DUSP3, a dual-specificity phosphatase, preferentially dephosphorylates phosphotyrosines. Its main function involves inactivating ERK1 and ERK2, thereby modulating associated cellular signaling pathways. DUSP3 Protein, Human (His) is the recombinant human-derived DUSP3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703898

	DUSP3 Protein, Human (sf9) Dual specificity protein phosphatase 3; DUSP3; Dual specificity protein phosphatase VHR; vaccinia H1-related phosphatase; VHR	Human	Sf9 insect cells
	DUSP3, a dual-specificity phosphatase, preferentially dephosphorylates phosphotyrosines. Its main function involves inactivating ERK1 and ERK2, thereby modulating associated cellular signaling pathways. DUSP3 Protein, Human (sf9) is the recombinant human-derived DUSP3 protein, expressed by Sf9 insect cells, with tag free.

HY-P701725

	VRK3 Protein, Human (sf9, His, GST) VRK3; Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; vaccinia-related kinase 3	Human	Sf9 insect cells
	Despite its inactive kinase state, VRK3 protein crucially regulates ERK activity by enhancing the phosphatase activity of DUSP3. The interaction with DUSP3 is pivotal as it dephosphorylates and inactivates ERK in the nucleus. VRK3, also interacting with the small GTPase RAN, forms a network of molecular interactions, positioning it as a key modulator in signaling pathways controlling ERK activity and nuclear cellular processes. VRK3 Protein, Human (sf9, His, GST) is the recombinant human-derived VRK3 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

HY-P70015

	*B18R Protein, Vaccinia* virus (HEK293, His)** rVaSoluble interferon alpha/beta receptor B18/VACWR200, His; Soluble interferon alpha/beta receptor B18; VACWR200	Virus	HEK293
	B18R protein functions as a potent antagonist against the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins, such as OAS1 involved in viral RNA degradation. It acts as a soluble IFN-alpha receptor, effectively impeding the interaction between host IFN-alpha and its receptor. The protein's ability to interact with host IFNA1 underscores its role in modulating the host's immune response against viral infections. B18R Protein, Vaccinia virus (HEK293, His) is the recombinant Virus-derived B18R protein, expressed by HEK293 , with C-6*His labeled tag.

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HY-14805S

Tecovirimat-d4

Tecovirimat-d₄ (ST-246-d₄) is a deuterium-labelled Tecovirimat (HY-14805). Tecovirimat is an orally bioavailable and selective compound against orthopoxviruses [including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), smallpox and variola viruses]. Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC₅₀ values of 0.01 μM, 0.48 μM and 0.05 μM, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein (p37) required for production of extracellular virus. Tecovirimat could be used in the study for orthopoxvirus-induced diseases .

HY-131606S

Cidofovir diphosphate-13C3

Cidofovir diphosphate- ¹³C₃ is the ¹³C-labeled Cidofovir diphosphate (HY-131606). Cidofovir diphosphate is the intracellular active metabolite of Cidofovir (HY-17438) and its oral prodrug Brincidofovir (HY-14532). By inhibiting viral DNA polymerase (Ki ≈ 76.3 μM), cidofovir diphosphate is widely used in studies on double-stranded DNA virus infections, including cytomegalovirus (CMV), adenovirus (AdV), and poxviruses (such as monkeypox and molluscum contagiosum virus, MCV) .

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HY-P80646

	DUSP3 Antibody Dual specificity protein phosphatase VHR; VHR; vaccinia H1-related phosphatase	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human
	DUSP3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to DUSP3.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / 해외재고보유 - + 장바구니에 담기 견적 받기

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HY-141567A

Pseudouridine 5'-triphosphate trisodium solution (100 mM) 1 Publications Verification Pseudo-UTP trisodium solution (100 mM)		Nucleotide Analogs
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection .

HY-141567

Pseudouridine 5'-triphosphate Pseudo-UTP		Nucleotide Analogs
Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection .

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