Enrofloxacin monohydrochloride
Based on 19 publication(s) in Google Scholar
Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 93106-59-3
- Formula: C19H23ClFN3O3
- Molecular Weight:395.86
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocol
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Antiviral Compound Library
HY-L027
-
Antibacterial Compound Library
HY-L049
-
FDA Approved & Pharmacopeial Drug Library
HY-L066
-
Antibiotics Library
HY-L067
-
Human Metabolite Library
HY-L123
-
Anti-Orthopoxvirus Compound Library
HY-L127
-
MCE Bioactive Compound Library
HY-L001V
-
RO5 Drug-like Natural Product Library
HY-L200
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
Publications Citing Use of MedChemExpress (MCE) Enrofloxacin monohydrochloride
More- Neuron. 2025 Oct 10:S0896-6273(25)00706-8. [Abstract]
- Neuron. 2021 Aug 18;109(16):2573-2589.e9. [Abstract]
- Adv Sci (Weinh). 2025 Jan;12(1):e2406766. [Abstract]
- Food Chem X. 2026 Feb 8:34:103646. [Abstract]
- Curr Biol. 2024 Jun 17;34(12):2644-2656.e7. [Abstract]
- Cell Rep. 2024 Feb 17;43(2):113804. [Abstract]
- Cell Rep. 2023 Mar 21;42(4):112290. [Abstract]
- Virulence. 2025 Dec;16(1):2595767. [Abstract]
- RSC Adv. 2026 Jan 2;16(1):657-666. [Abstract]
- PLoS Pathog. 2026 Jan 26;22(1):e1013903. [Abstract]
- Microorganisms. 2025 Apr 18;13(4):938. [Abstract]
- Aquaculture. 30 January 2022, 737541.
- Microbiol Spectr. 2025 Jul;13(7):e0307424. [Abstract]
- Vet Microbiol. 2024 May:292:110046. [Abstract]
- J Immunotoxicol. 2026 Dec;23(1):2660647. [Abstract]
- bioRxiv. 2024 Nov 06.
- Chemosphere. 2023 Nov:340:139892. [Abstract]
- Phys Chem Res. 2021 9(2): 327-344.
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
All Antibiotic Isoforms
More
Biological Activity
|
Quinolone |
Mycoplasma bovis is a worldwide pathogen, causative agent of pneumonia, mastitis, arthritis, and a variety of other symptoms in cattle. The antibiotic susceptibility profiles of the Hungarian strains are consistent within the tested group of fluoroquinolones. Three isolates (MYC44, MYC45 and MYC46) have high MIC values (≥10 μg/mL) to Enrofloxacin, while the rest of the strains are inhibited by Enrofloxacin with MICs ≤0.312 or 0.625 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 93106-59-3
-
Appearance Solid
-
Molecular Weight 395.86
-
Formula C19H23ClFN3O3
-
Color White to off-white
-
SMILES
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCN(CC)CC4)=C3)C1=O)O.[H]Cl
-
Synonyms
BAY Vp 2674 monohydrochloride; PD160788 monohydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (19)
-
Journal Impact Factor
-
Most Recent
-
Neuron
Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders. [Abstract]2025 Oct 10:S0896-6273(25)00706-8. PMID: 41075784 -
Neuron
Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines. [Abstract]2021 Aug 18;109(16):2573-2589.e9. PMID: 34233151 -
Adv Sci (Weinh)
2025 Jan;12(1):e2406766. PMID: 39487959 -
Food Chem X
Machine learning prioritization of antibiotic residues in aquatic foods reveals exposure-driven genotoxic risk mediated by BCL2. [Abstract]2026 Feb 8:34:103646. PMID: 41756597 -
Curr Biol
2024 Jun 17;34(12):2644-2656.e7. PMID: 38810638 -
Cell Rep
A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation. [Abstract]2024 Feb 17;43(2):113804. PMID: 38368612 -
Cell Rep
2023 Mar 21;42(4):112290. PMID: 36947545 -
Virulence
Negative regulation of reassortant canine influenza virus replication and key site identification in porcine and ferret bronchial epithelial cell lines. [Abstract]2025 Dec;16(1):2595767. PMID: 41307451 -
RSC Adv
Multifunctional Cu-DEOD porous polymeric nanocomposite for broad-spectrum biomedical applications. [Abstract]2026 Jan 2;16(1):657-666. PMID: 41488521 -
PLoS Pathog
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]2026 Jan 26;22(1):e1013903. PMID: 41587213 -
Microorganisms
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023. [Abstract]2025 Apr 18;13(4):938. PMID: 40284774 -
-
Microbiol Spectr
Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan. [Abstract]2025 Jul;13(7):e0307424. PMID: 40387379 -
Vet Microbiol
Discovery of the tigecycline resistance gene cluster tmexCD3-toprJ1 in Pasteurella multocida strains isolated from pigs in China. [Abstract]2024 May:292:110046. PMID: 38471428 -
J Immunotoxicol
Lung microbiota dysbiosis mediates PM2.5-induced pulmonary inflammation through antibiotic-reversible mechanisms. [Abstract]2026 Dec;23(1):2660647. PMID: 42024669 -
-
Chemosphere
Enrofloxacin (ENR) exposure induces lipotoxicity by promoting mitochondrial fragmentation via dephosphorylation of DRP1 at S627 site. [Abstract]2023 Nov:340:139892. PMID: 37611774 -
-
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Solvent & Solubility
H2O : 7.14 mg/mL (18.04 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Mice[2]
11- to 14-week-old C57Bl6/J male mice are used. Enrofloxacin (2.5% oral solution) is dispensed in saline (2 mg/mL), antibiotic-treated animals receive a daily orally dispensed dose of 10 mg/kg body weight via feeding needle every 12 hours over a period of 7 days, while placebo animals receive the same amount of saline via feeding needle. Animals of preventive antibiotic group obtained Enrofloxacin after waking from reperfusion anesthesia (ca. 1 hour after operation). Therapeutic antibiotic treatment is given immediately after appearance of clinical signs (general health score>5) and confirmation of lung infection by MRI (signal rate≥5%). The group allocation is randomized[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Sulyok KM, et al.Antibiotic susceptibility profiles of Mycoplasma bovis strains isolated from cattle in Hungary, Central Europe. BMC Vet Res. 2014 Oct 25;10:256. [Content Brief]
[2]. Hetze S, et al. Superiority of preventive antibiotic treatment compared with standard treatment of poststroke pneumonia in experimental stroke: a bed to bench approach. J Cereb Blood Flow Metab. 2013 Jun;33(6):846-54. [Content Brief]
[3]. S Ikeda , et al. Antiviral activity and inhibition of topoisomerase by ofloxacin, a new quinolone derivative. Antiviral Res. 1987 Oct;8(3):103-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.5261 mL | 12.6307 mL | 25.2615 mL | 63.1536 mL |
| 5 mM | 0.5052 mL | 2.5261 mL | 5.0523 mL | 12.6307 mL | |
| 10 mM | 0.2526 mL | 1.2631 mL | 2.5261 mL | 6.3154 mL | |
| 15 mM | 0.1684 mL | 0.8420 mL | 1.6841 mL | 4.2102 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Enrofloxacin monohydrochloride Related Classifications
HY-B0502A Related Classifications
Powered by Bioz