Cat. No.: HY-W091784

3'-O-Methylguanosine

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Based on 1 Customer Validation

3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA.

For research use only. We do not sell to patients.

Purity: 99.98%
CAS No.: 10300-27-3
Formula: C₁₁H₁₅N₅O₅
Molecular Weight:297.27

Storage:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

3'-O-Methylguanosine Chemical Structure

CAS No.: 10300-27-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA^[1].

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All DNA/RNA Synthesis Isoforms :

In Vitro

3'-O-Methylguanosine (10-100 μM) inhibits the plaque formation of vaccinia virus in both L-cells and Vero cells; inhibits vaccinia virus-specific early RNA synthesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 10300-27-3
Appearance Solid
Molecular Weight 297.27
Formula C₁₁H₁₅N₅O₅
Color White to off-white
SMILES

O[C@@H]1[C@H](OC)[C@@H](CO)O[C@H]1N2C=NC3=C2NC(N)=NC3=O
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (84.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3639 mL

16.8197 mL

33.6395 mL

5 mM

0.6728 mL

3.3639 mL

6.7279 mL

10 mM

0.3364 mL

1.6820 mL

3.3639 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. B B Goswami, et al. Inhibition of vaccinia virus growth and virus-specific RNA synthesis by 3'-O-methyl adenosine and 3'-O-methyl guanosine. J Virol. 1983 Mar;45(3):1164-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3639 mL	16.8197 mL	33.6395 mL	84.0986 mL
	5 mM	0.6728 mL	3.3639 mL	6.7279 mL	16.8197 mL
	10 mM	0.3364 mL	1.6820 mL	3.3639 mL	8.4099 mL
	15 mM	0.2243 mL	1.1213 mL	2.2426 mL	5.6066 mL
	20 mM	0.1682 mL	0.8410 mL	1.6820 mL	4.2049 mL
	25 mM	0.1346 mL	0.6728 mL	1.3456 mL	3.3639 mL
	30 mM	0.1121 mL	0.5607 mL	1.1213 mL	2.8033 mL
	40 mM	0.0841 mL	0.4205 mL	0.8410 mL	2.1025 mL
	50 mM	0.0673 mL	0.3364 mL	0.6728 mL	1.6820 mL
	60 mM	0.0561 mL	0.2803 mL	0.5607 mL	1.4016 mL
	80 mM	0.0420 mL	0.2102 mL	0.4205 mL	1.0512 mL

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3'-O-Methylguanosine

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All Endogenous Metabolite Isoforms

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

3'-O-Methylguanosine Related Classifications

HY-W091784 Related Classifications