2. Induced Disease Models Products Immunology/Inflammation Anti-infection
  3. Immunology and Inflammatory Disease Models Digestive System Disease Models COX Antibiotic Influenza Virus Bacterial
  4. Gastrointestinal Inflammation and Ulcer Models Gastrointestinal Disease Models
  5. Gastric Ulcer Models
  6. Indomethacin

Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research.

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No. CAS : 53-86-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Revisión del cliente

Based on 76 publication(s) in Google Scholar

Other Forms of Indomethacin:

Indomethacin Related Antibodies

Top Publications Citing Use of Products

76 Publications Citing Use of MCE Indomethacin

ELISA
WB
IF
Cell Proliferation/Viability Assay
In Vivo Efficacy Study

    Indomethacin purchased from MedChemExpress. Usage Cited in: Hepatology. 2023 Feb 1;77(2):456-465.  [Abstract]

    WT BmEos was treated with IL-33 (20 ng/ml) in the presence or absence of indomethacin (50 μM) for 24 h. Protein levels of IL-4 and IL-13 in the supernatants were measured by ELISA.

    Indomethacin purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548.  [Abstract]

    ITGAV, ITGB3, p-FAK, FAK, p-PI3K, PI3K, p-AKT, AKT, p-GSK3β, and GSK3β protein levels were assessed in KYSE30 cells by Western blotting after treatment with DMSO or 200 µM Indomethacin (0–96 h).

    Indomethacin purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548.  [Abstract]

    HEK-293T cells were co-transfected with FLAG-ITGAV and HA-ubiquitin plasmids, pre-treated with MG132 for 12 h, and then incubated with indomethacin (200 µM) for 2 days.

    Indomethacin purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548.  [Abstract]

    KYSE30 and KYSE510 cells were treated with DMSO or Indomethacin for 24 h, followed by the detection of ITGAV protein levels using immunofluorescence.

    Indomethacin purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548.  [Abstract]

    ESCC cells were treated with DMSO or different concentrations of Indomethacin for various times (24, 48, or 96 h). Cell growth inhibition was detected by MTT assay.

    Indomethacin purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548.  [Abstract]

    PDX tumour size was plotted over 41 days (LEG74, n = 8/group), 26 days (LEG92, n = 12/group), or 13 days (LEG84, n = 10/group) to assess the effect of Indomethacin. Vehicle or indomethacin (1 or 4 mg/kg) was administered intra-gastrically. Tumour volumes were measured twice per week.

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    Descripciòn

    Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research[1][2][3].

    IC50 & Target[1]

    Human COX-1

    18 nM (IC50, in CHO cells)

    Human COX-2

    26 nM (IC50, in CHO cells)

    Cellular Effect
    Cell Line Type Value Description References
    2008 IC50
    12.6 3
    Compound: indometacin
    Inhibition of MRP1 expressed in human 2008 cells assessed as calcein AM accumulation by cell based assay
    Inhibition of MRP1 expressed in human 2008 cells assessed as calcein AM accumulation by cell based assay
    		[PMID: 21354800]
    2008 IC50
    12 3
    Compound: Indomethacin
    Inhibition of human MRP1 in human 2008 cells
    Inhibition of human MRP1 in human 2008 cells
    		[PMID: 18707884]
    2008 IC50
    12 3
    Compound: Indomethacin
    Inhibition of human MRP1 in human 2008 cells
    Inhibition of human MRP1 in human 2008 cells
    		[PMID: 18707884]
    2008 IC50
    12.6 3
    Compound: indometacin
    Inhibition of MRP1 expressed in human 2008 cells assessed as calcein AM accumulation by cell based assay
    Inhibition of MRP1 expressed in human 2008 cells assessed as calcein AM accumulation by cell based assay
    		[PMID: 21354800]
    A549 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    2008 IC50
    12.6 3
    Compound: indometacin
    Inhibition of MRP1 expressed in human 2008 cells assessed as calcein AM accumulation by cell based assay
    Inhibition of MRP1 expressed in human 2008 cells assessed as calcein AM accumulation by cell based assay
    		[PMID: 21354800]
    A549 IC50
    40.6 3
    Compound: indomethacin
    Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis
    Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis
    		[PMID: 22992107]
    A549 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    HeLa EC50
    0.14 1
    Compound: 1, IMN
    Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay
    Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay
    		[PMID: 23432095]
    A549 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    A549 IC50
    >100 3
    Compound: Indomethacin
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    A549 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32987314]
    A549 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    A549 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32987314]
    A549 IC50
    >50 3
    Compound: Indometacin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    A549 IC50
    40.6 3
    Compound: indomethacin
    Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis
    Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis
    		[PMID: 22992107]
    A549 IC50
    40.6 3
    Compound: indomethacin
    Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis
    Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as inhibition of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis
    		[PMID: 22992107]
    A549 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32987314]
    Bel-7402 IC50
    >100 3
    Compound: Indomethacin
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    A549 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32987314]
    Bel-7402 IC50
    > 100 3
    Compound: Indomethacin
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    BJ IC50
    > 50 3
    Compound: C
    Cytotoxicity against human BJ cells after 72 hrs by luminescence assay
    Cytotoxicity against human BJ cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    Bel7402/5-FU IC50
    > 100 3
    Compound: Indomethacin
    Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    Bel7402/5-FU IC50
    >100 3
    Compound: Indomethacin
    Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    BV-2 IC50
    15.2 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production
    Anti-inflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production
    		[PMID: 37683361]
    BJ IC50
    > 50 3
    Compound: C
    Cytotoxicity against human BJ cells after 72 hrs by luminescence assay
    Cytotoxicity against human BJ cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    BJ IC50
    >50 3
    Compound: C
    Cytotoxicity against human BJ cells after 72 hrs by luminescence assay
    Cytotoxicity against human BJ cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    BV-2 IC50
    34.5 3
    Compound: Indomethacin
    Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 10 mins followed by LPS stimulation for 24 hrs by Griess assay
    Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 10 mins followed by LPS stimulation for 24 hrs by Griess assay
    		[PMID: 27120704]
    BV-2 IC50
    7.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 24042007]
    BV-2 IC50
    19.51 3
    Compound: Indomethacin
    Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production by griess assay
    Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production by griess assay
    		[PMID: 37530709]
    BV-2 IC50
    34.5 3
    Compound: Indomethacin
    Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 10 mins followed by LPS stimulation for 24 hrs by Griess assay
    Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 10 mins followed by LPS stimulation for 24 hrs by Griess assay
    		[PMID: 27120704]
    BV-2 IC50
    35.7 3
    Compound: indomethacin
    Inhibition of LPS-activated nitric oxide production in mouse BV2 cells pre-treated for 60 mins before LPS challenge for 24 hrs by Griess assay
    Inhibition of LPS-activated nitric oxide production in mouse BV2 cells pre-treated for 60 mins before LPS challenge for 24 hrs by Griess assay
    		[PMID: 26348503]
    BV-2 IC50
    34.5 3
    Compound: Indomethacin
    Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 10 mins followed by LPS stimulation for 24 hrs by Griess assay
    Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 10 mins followed by LPS stimulation for 24 hrs by Griess assay
    		[PMID: 27120704]
    BV-2 IC50
    35.7 3
    Compound: indomethacin
    Inhibition of LPS-activated nitric oxide production in mouse BV2 cells pre-treated for 60 mins before LPS challenge for 24 hrs by Griess assay
    Inhibition of LPS-activated nitric oxide production in mouse BV2 cells pre-treated for 60 mins before LPS challenge for 24 hrs by Griess assay
    		[PMID: 26348503]
    BV-2 IC50
    7.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 24042007]
    BV-2 IC50
    19.51 3
    Compound: Indomethacin
    Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production by griess assay
    Antineuroinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production by griess assay
    		[PMID: 37530709]
    BV-2 IC50
    55.44 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production pretreated for 1 hr followed by LPS-stimulation and measured after 18 hrs by 2,3-diaminonaphthalene reagent based fluorescence analysis
    Anti-inflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production pretreated for 1 hr followed by LPS-stimulation and measured after 18 hrs by 2,3-diaminonaphthalene reagent based fluorescence analysis
    		[PMID: 37683361]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
    In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
    		[PMID: 9873621]
    BV-2 IC50
    35.7 3
    Compound: indomethacin
    Inhibition of LPS-activated nitric oxide production in mouse BV2 cells pre-treated for 60 mins before LPS challenge for 24 hrs by Griess assay
    Inhibition of LPS-activated nitric oxide production in mouse BV2 cells pre-treated for 60 mins before LPS challenge for 24 hrs by Griess assay
    		[PMID: 26348503]
    CHO IC50
    0.049 3
    Compound: Indomethacin
    Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
    Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
    		10.1016/S0960-894X(96)00501-X
    BV-2 IC50
    7.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 24042007]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
    In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
    		[PMID: 9873621]
    CHO IC50
    0.018 3
    Compound: Indomethacin
    In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-1
    In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-1
    		10.1016/S0960-894X(96)00580-X
    CHO IC50
    25 3
    Compound: 5
    Modulation of gamma-secretase-mediated cleavage of human APP expressed in CHO cells with human presenilin-1 assessed as inhibition of amyloid beta42 production after 24 hrs by ELISA
    Modulation of gamma-secretase-mediated cleavage of human APP expressed in CHO cells with human presenilin-1 assessed as inhibition of amyloid beta42 production after 24 hrs by ELISA
    		[PMID: 20503989]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-2
    In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-2
    		10.1016/S0960-894X(96)00580-X
    CHO IC50
    25 3
    Compound: 2
    Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as inhibition of amyloid beta42 production by ELISA
    Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as inhibition of amyloid beta42 production by ELISA
    		[PMID: 21873070]
    COS-7 IC50
    > 1000 3
    Compound: Indomethacin
    Cytotoxicity against African green monkey COS7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Cytotoxicity against African green monkey COS7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    CHO IC50
    0.018 3
    Compound: Indomethacin
    In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cells
    In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cells
    		[PMID: 10576684]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells
    In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells
    		[PMID: 10576684]
    CV-1 EC50
    50 3
    Compound: Indomethacin
    Activation of GAL4 fused human PPARgamma ligand binding domain transfected in african green monkey CV1 cells by CAT reporter assay
    Activation of GAL4 fused human PPARgamma ligand binding domain transfected in african green monkey CV1 cells by CAT reporter assay
    		[PMID: 16643023]
    CHO IC50
    0.049 3
    Compound: Indomethacin
    Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
    Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
    		10.1016/S0960-894X(96)00501-X
    DU-145 IC50
    > 100 3
    Compound: 4; Ind
    Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    Erythrocyte IC50
    0.086 6
    Compound: Indomethacin
    Hemolytic activity in human RBC assessed as membrane mortification by absorbance method
    Hemolytic activity in human RBC assessed as membrane mortification by absorbance method
    		[PMID: 29803359]
    CHO IC50
    0.039 3
    Compound: Indomethacin
    Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1
    Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1
    		10.1016/S0960-894X(96)00501-X
    CHO IC50
    0.026 3
    Compound: Indomethacin
    Inhibition of PGE-2 production in CHO cells expressing human COX-2.
    Inhibition of PGE-2 production in CHO cells expressing human COX-2.
    		[PMID: 10576685]
    Erythrocyte IC50
    40 6
    Compound: Indomethacin
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    		[PMID: 30108882]
    CHO IC50
    25 3
    Compound: 2
    Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as inhibition of amyloid beta42 production by ELISA
    Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as inhibition of amyloid beta42 production by ELISA
    		[PMID: 21873070]
    Bel-7402 IC50
    > 100 3
    Compound: Indomethacin
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    Erythrocyte IC50
    40.04 6
    Compound: Indomethacin
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    		[PMID: 30108827]
    CHO IC50
    25 3
    Compound: 5
    Modulation of gamma-secretase-mediated cleavage of human APP expressed in CHO cells with human presenilin-1 assessed as inhibition of amyloid beta42 production after 24 hrs by ELISA
    Modulation of gamma-secretase-mediated cleavage of human APP expressed in CHO cells with human presenilin-1 assessed as inhibition of amyloid beta42 production after 24 hrs by ELISA
    		[PMID: 20503989]
    Bel7402/5-FU IC50
    > 100 3
    Compound: Indomethacin
    Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human Bel7402/5-FU cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    HCT-116 IC50
    136.8 3
    Compound: INDO
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    CHO IC50
    0.018 3
    Compound: Indomethacin
    In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-1
    In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-1
    		10.1016/S0960-894X(96)00580-X
    HCT-15 IC50
    > 1000 3
    Compound: Indomethacin
    Anticancer activity against human HCT15 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human HCT15 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    CHO IC50
    0.018 3
    Compound: Indomethacin
    Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells
    Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells
    		10.1016/S0960-894X(96)00582-3
    CHO IC50
    0.018 3
    Compound: Indomethacin
    Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells
    Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells
    		10.1016/S0960-894X(96)00582-3
    HEK293 IC50
    > 50 3
    Compound: C
    Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
    Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells
    Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells
    		10.1016/S0960-894X(96)00582-3
    CHO IC50
    0.018 3
    Compound: Indomethacin
    In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cells
    In vitro inhibitory potency against human COX-1 in stably transfected chinese hamster ovary (CHO) cells
    		[PMID: 10576684]
    HEK293 IC50
    > 500 3
    Compound: indomethacin
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    CHO IC50
    3 3
    Compound: Indomethacin
    TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells
    TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells
    		[PMID: 10991954]
    HEK293 IC50
    12 3
    Compound: Indometacin
    Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting
    Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting
    		[PMID: 22541068]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-2
    In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-2
    		10.1016/S0960-894X(96)00580-X
    THP-1 IC50
    3.6 1
    Compound: Indomethacin
    Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    HEK293 IC50
    140 3
    Compound: Indometacin
    Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting
    Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting
    		[PMID: 22541068]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells
    Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells
    		10.1016/S0960-894X(96)00582-3
    COS-7 IC50
    >1 2
    Compound: Indomethacin
    Cytotoxicity against African green monkey COS7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Cytotoxicity against African green monkey COS7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    HEK293 IC50
    41 3
    Compound: Indometacin
    Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting
    Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting
    		[PMID: 22541068]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells
    In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells
    		[PMID: 10576684]
    CV-1 EC50
    50 3
    Compound: Indomethacin
    Activation of GAL4 fused human PPARgamma ligand binding domain transfected in african green monkey CV1 cells by CAT reporter assay
    Activation of GAL4 fused human PPARgamma ligand binding domain transfected in african green monkey CV1 cells by CAT reporter assay
    		[PMID: 16643023]
    HeLa IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    DU-145 IC50
    >100 3
    Compound: 4; Ind
    Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    Inhibition of PGE-2 production in CHO cells expressing human COX-2.
    Inhibition of PGE-2 production in CHO cells expressing human COX-2.
    		[PMID: 10576685]
    CHO IC50
    0.026 3
    Compound: Indomethacin
    In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
    In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
    		[PMID: 9873621]
    Erythrocyte IC50
    40.04 6
    Compound: Indomethacin
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    		[PMID: 30108827]
    HeLa IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32987314]
    CHO IC50
    0.039 3
    Compound: Indomethacin
    Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1
    Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1
    		10.1016/S0960-894X(96)00501-X
    Erythrocyte IC50
    40 6
    Compound: Indomethacin
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    		[PMID: 30108882]
    HeLa IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32987314]
    CHO IC50
    0.049 3
    Compound: Indomethacin
    Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
    Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
    		10.1016/S0960-894X(96)00501-X
    Erythrocyte IC50
    0.086 6
    Compound: Indomethacin
    Hemolytic activity in human RBC assessed as membrane mortification by absorbance method
    Hemolytic activity in human RBC assessed as membrane mortification by absorbance method
    		[PMID: 29803359]
    HeLa EC50
    0.14 1
    Compound: 1, IMN
    Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay
    Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay
    		[PMID: 23432095]
    CHO IC50
    25 3
    Compound: 2
    Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as inhibition of amyloid beta42 production by ELISA
    Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as inhibition of amyloid beta42 production by ELISA
    		[PMID: 21873070]
    HeLa IC50
    50 3
    Compound: Indomethacin
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    HCT-116 EC50
    136.8 3
    Compound: Indomethacin
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability
    		[PMID: 33569941]
    CHO IC50
    25 3
    Compound: 5
    Modulation of gamma-secretase-mediated cleavage of human APP expressed in CHO cells with human presenilin-1 assessed as inhibition of amyloid beta42 production after 24 hrs by ELISA
    Modulation of gamma-secretase-mediated cleavage of human APP expressed in CHO cells with human presenilin-1 assessed as inhibition of amyloid beta42 production after 24 hrs by ELISA
    		[PMID: 20503989]
    HepG2 IC50
    > 50 3
    Compound: C
    Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
    Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    HCT-116 IC50
    136.8 3
    Compound: INDO
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    CHO IC50
    3 3
    Compound: Indomethacin
    TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells
    TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells
    		[PMID: 10991954]
    HCT-15 IC50
    >1 2
    Compound: Indomethacin
    Anticancer activity against human HCT15 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human HCT15 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    HT-29 IC50
    > 100 3
    Compound: 4; Ind
    Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    HT-29 IC50
    1052 3
    Compound: Indomethacin
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 22940705]
    HEK293 IC50
    >50 3
    Compound: C
    Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
    Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    HEK293 IC50
    12 3
    Compound: Indometacin
    Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting
    Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting
    		[PMID: 22541068]
    HT-29 IC50
    312.6 3
    Compound: INDO
    Antiproliferative activity against human HT-29 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human HT-29 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    J774 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against mouse J774 cells assessed as cell survival after 24 hrs by MTT assay
    Cytotoxicity against mouse J774 cells assessed as cell survival after 24 hrs by MTT assay
    		[PMID: 24268542]
    HEK293 IC50
    41 3
    Compound: Indometacin
    Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting
    Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting
    		[PMID: 22541068]
    J774 IC50
    29.6 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 24268542]
    HEK293 IC50
    140 3
    Compound: Indometacin
    Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting
    Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting
    		[PMID: 22541068]
    J774.A1 IC50
    28.42 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774A1 cells assessed as reduction of LPS-induced nitric oxide production treated 2 hrs before LPS addition measured after 20 hrs by using Griess reagent
    Antiinflammatory activity in mouse J774A1 cells assessed as reduction of LPS-induced nitric oxide production treated 2 hrs before LPS addition measured after 20 hrs by using Griess reagent
    		[PMID: 23688954]
    HEK293 IC50
    >500 3
    Compound: indomethacin
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    HeLa IC50
    50 3
    Compound: Indomethacin
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    J774.A1 IC50
    28.56 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production treated 2 hrs before LPS challenge measured after 20 hrs
    Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production treated 2 hrs before LPS challenge measured after 20 hrs
    		[PMID: 25140384]
    K562 IC50
    190 3
    Compound: Indomethacin
    Anticancer activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    HeLa IC50
    >50 3
    Compound: Indometacin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    HepG2 IC50
    >50 3
    Compound: C
    Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
    Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    L02 IC50
    > 100 3
    Compound: Indomethacin
    Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    HT-29 EC50
    312.6 3
    Compound: Indomethacin
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability
    		[PMID: 33569941]
    LNCaP IC50
    > 300 3
    Compound: Indomethacin
    Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 28057407]
    HT-29 IC50
    1052 3
    Compound: Indomethacin
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 22940705]
    COS-7 IC50
    > 1000 3
    Compound: Indomethacin
    Cytotoxicity against African green monkey COS7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Cytotoxicity against African green monkey COS7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    LNCaP IC50
    238.4 3
    Compound: INDO
    Antiproliferative activity against human LNCAP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human LNCAP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    CV-1 EC50
    50 3
    Compound: Indomethacin
    Activation of GAL4 fused human PPARgamma ligand binding domain transfected in african green monkey CV1 cells by CAT reporter assay
    Activation of GAL4 fused human PPARgamma ligand binding domain transfected in african green monkey CV1 cells by CAT reporter assay
    		[PMID: 16643023]
    HT-29 IC50
    >100 3
    Compound: 4; Ind
    Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    Macrophage IC50
    22 3
    Compound: indomethacin
    Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced PGE2 release by Ellman's method
    Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced PGE2 release by Ellman's method
    		[PMID: 8988605]
    MCF7 IC50
    > 100 3
    Compound: 4; Ind
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    HT-29 IC50
    312.6 3
    Compound: INDO
    Antiproliferative activity against human HT-29 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human HT-29 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    MCF7 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    Sf9 IC50
    30 1
    Compound: 1
    Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)
    Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)
    		[PMID: 11392547]
    J774 IC50
    29.6 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 24268542]
    MCF7 IC50
    > 1000 3
    Compound: Indomethacin
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    J774 IC50
    >100 3
    Compound: Indomethacin
    Cytotoxicity against mouse J774 cells assessed as cell survival after 24 hrs by MTT assay
    Cytotoxicity against mouse J774 cells assessed as cell survival after 24 hrs by MTT assay
    		[PMID: 24268542]
    MCF7 IC50
    > 50 3
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35468536]
    J774 IC50
    0.002 3
    Compound: Indomethacin
    In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cells
    In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cells
    		[PMID: 15857149]
    MCF7 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    DU-145 IC50
    > 100 3
    Compound: 4; Ind
    Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    MCF7 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32987314]
    J774 IC50
    0.009 3
    Compound: Indomethacin
    In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cells
    In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cells
    		[PMID: 15857149]
    MCF7 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32987314]
    J774.A1 IC50
    28.56 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production treated 2 hrs before LPS challenge measured after 20 hrs
    Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production treated 2 hrs before LPS challenge measured after 20 hrs
    		[PMID: 25140384]
    MDA-MB-231 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    Erythrocyte IC50
    0.086 6
    Compound: Indomethacin
    Hemolytic activity in human RBC assessed as membrane mortification by absorbance method
    Hemolytic activity in human RBC assessed as membrane mortification by absorbance method
    		[PMID: 29803359]
    J774.A1 IC50
    28.42 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774A1 cells assessed as reduction of LPS-induced nitric oxide production treated 2 hrs before LPS addition measured after 20 hrs by using Griess reagent
    Antiinflammatory activity in mouse J774A1 cells assessed as reduction of LPS-induced nitric oxide production treated 2 hrs before LPS addition measured after 20 hrs by using Griess reagent
    		[PMID: 23688954]
    Neutrophil IC50
    271.212 3
    Compound: Indomethacin
    Antiinflammatory activity in human neutrophils assessed as inhibition of opsonized zymosan A-mediated superoxide anions production by WST-1 based respiratory burst assay
    Antiinflammatory activity in human neutrophils assessed as inhibition of opsonized zymosan A-mediated superoxide anions production by WST-1 based respiratory burst assay
    		[PMID: 22437110]
    Erythrocyte IC50
    40.04 6
    Compound: Indomethacin
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    		[PMID: 30108827]
    K562 IC50
    190 3
    Compound: Indomethacin
    Anticancer activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    Erythrocyte IC50
    40 6
    Compound: Indomethacin
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    Anti-inflammatory activity in human RBC assessed as inhibition of hypotonic solution-induced hemolysis after 10 mins by spectrophotometric method
    		[PMID: 30108882]
    Neutrophil IC50
    38.3 3
    Compound: Indomethacin
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
    		[PMID: 21316977]
    L02 IC50
    >100 3
    Compound: Indomethacin
    Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    LNCaP EC50
    238.4 3
    Compound: Indomethacin
    Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability
    Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability
    		[PMID: 33569941]
    PC-3 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    PC-3 IC50
    > 1000 3
    Compound: Indomethacin
    Anticancer activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    LNCaP IC50
    238.4 3
    Compound: INDO
    Antiproliferative activity against human LNCAP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human LNCAP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    Platelet IC50
    0.1 3
    Compound: Indomethacin
    Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    LNCaP IC50
    >300 3
    Compound: Indomethacin
    Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 28057407]
    Platelet IC50
    0.21 3
    Compound: Indomethacin
    Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet-rich blood by turbidimetric method
    Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet-rich blood by turbidimetric method
    		[PMID: 8988600]
    RAW264.7 IC50
    52.8 1
    Compound: Indomethacin
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
    		[PMID: 19467877]
    Macrophage IC50
    22 87
    Compound: indomethacin
    Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced PGE2 release by Ellman's method
    Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced PGE2 release by Ellman's method
    		[PMID: 8988605]
    Platelet IC50
    1.62 3
    Compound: Indomethacin
    Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins before arachidonic acid challenge by turbidimetric method
    Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins before arachidonic acid challenge by turbidimetric method
    		[PMID: 23639653]
    HCT-116 EC50
    136.8 3
    Compound: Indomethacin
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability
    Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability
    		[PMID: 33569941]
    Platelet IC50
    2.8 3
    Compound: Indomethacin
    Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    HCT-116 IC50
    136.8 3
    Compound: INDO
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    Platelet IC50
    3.2 3
    Compound: Indomethacin
    Inhibition of epinephrine hydrochloride-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of epinephrine hydrochloride-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    HCT-15 IC50
    > 1000 3
    Compound: Indomethacin
    Anticancer activity against human HCT15 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human HCT15 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    Raji IC50
    > 50 3
    Compound: C
    Cytotoxicity against human Raji cells after 72 hrs by luminescence assay
    Cytotoxicity against human Raji cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    MCF7 IC50
    >1 2
    Compound: Indomethacin
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    MCF7 IC50
    >100 3
    Compound: 4; Ind
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    RAW IC50
    15.37 3
    Compound: indomethacin
    Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISA
    Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISA
    		[PMID: 21381754]
    HEK293 IC50
    12 3
    Compound: Indometacin
    Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting
    Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake by scintillation counting
    		[PMID: 22541068]
    RAW IC50
    23.47 3
    Compound: indomethacin
    Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method
    Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method
    		[PMID: 21381754]
    MCF7 IC50
    >100 3
    Compound: Indomethacin
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    MCF7 IC50
    >50 3
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35468536]
    HEK293 IC50
    140 3
    Compound: Indometacin
    Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting
    Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake incubated for 5 mins by scintillation counting
    		[PMID: 22541068]
    RAW IC50
    48.89 3
    Compound: indomethacin
    Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysis
    Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysis
    		[PMID: 21381754]
    RAW264.7 IC50
    > 10 3
    Compound: Ind
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
    		[PMID: 32823004]
    MCF7 IC50
    >50 3
    Compound: Indometacin
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    HEK293 IC50
    41 3
    Compound: Indometacin
    Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting
    Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake incubated for 5 mins by scintillation counting
    		[PMID: 22541068]
    HEK293 IC50
    > 50 3
    Compound: C
    Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
    Cytotoxicity against HEK293 cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    MDA-MB-231 IC50
    >100 3
    Compound: Indomethacin
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    RAW264.7 IC50
    > 100 3
    Compound: indomethacin
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 21381754]
    HEK293 IC50
    > 500 3
    Compound: indomethacin
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
    		[PMID: 23241029]
    RAW264.7 IC50
    > 100 3
    Compound: indomethacin
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 21381754]
    RAW264.7 CC50
    > 200 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 27575472]
    RAW264.7 IC50
    > 40 3
    Compound: Ind
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in presence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in presence of LPS by MTT assay
    		[PMID: 32823004]
    RAW264.7 IC50
    > 40 3
    Compound: Ind
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
    		[PMID: 32823004]
    Neutrophil IC50
    32 3
    Compound: Indomethacin
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release
    		[PMID: 21316977]
    Neutrophil IC50
    38.3 3
    Compound: Indomethacin
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
    		[PMID: 21316977]
    RAW264.7 CC50
    > 50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 31365251]
    RAW264.7 IC50
    > 50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells by MTT assay
    Cytotoxicity against mouse RAW264.7 cells by MTT assay
    		[PMID: 30920218]
    Neutrophil IC50
    31.98 6
    Compound: Indomethacin
    Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
    Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
    		[PMID: 21848266]
    RAW264.7 IC50
    > 80 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 25555141]
    Neutrophil IC50
    38.32 6
    Compound: Indomethacin
    Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
    Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
    		[PMID: 21848266]
    Neutrophil IC50
    271.212 3
    Compound: Indomethacin
    Antiinflammatory activity in human neutrophils assessed as inhibition of opsonized zymosan A-mediated superoxide anions production by WST-1 based respiratory burst assay
    Antiinflammatory activity in human neutrophils assessed as inhibition of opsonized zymosan A-mediated superoxide anions production by WST-1 based respiratory burst assay
    		[PMID: 22437110]
    RAW264.7 IC50
    > 80 3
    Compound: Indo
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 25555141]
    RAW264.7 IC50
    > 80 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the absence of LPS
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the absence of LPS
    		[PMID: 22633833]
    Neutrophil IC50
    246.35 3
    Compound: Indometacin
    Antiinflammatory activity in human neutrophils assessed as inhibition of respiratory burst
    Antiinflammatory activity in human neutrophils assessed as inhibition of respiratory burst
    		[PMID: 20576329]
    HT-29 EC50
    312.6 3
    Compound: Indomethacin
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability
    Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability
    		[PMID: 33569941]
    RAW264.7 IC50
    > 80 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the presence of LPS
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the presence of LPS
    		[PMID: 22633833]
    Neutrophil IC50
    757.99 6
    Compound: indomethacin
    Antiinflammatory activity in human neutrophils assessed inhibition of superoxide anions production
    Antiinflammatory activity in human neutrophils assessed inhibition of superoxide anions production
    		[PMID: 19006373]
    HT-29 IC50
    1052 3
    Compound: Indomethacin
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 22940705]
    RAW264.7 IC50
    0.62 3
    Compound: Ind
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    		[PMID: 36888988]
    Neutrophil IC50
    >40 3
    Compound: indomethacin
    Antiinflammatory activity in neutrophil assessed as inhibition of fMLP induced elastase release
    Antiinflammatory activity in neutrophil assessed as inhibition of fMLP induced elastase release
    		[PMID: 17197180]
    RAW264.7 IC50
    1.25 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 24806310]
    HT-29 IC50
    312.6 3
    Compound: INDO
    Antiproliferative activity against human HT-29 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human HT-29 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    PC-3 IC50
    >1 2
    Compound: Indomethacin
    Anticancer activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    PC-3 IC50
    >100 3
    Compound: Indomethacin
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    RAW264.7 IC50
    10.7 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in absence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in absence of LPS by MTT assay
    		[PMID: 25881822]
    HT-29 IC50
    > 100 3
    Compound: 4; Ind
    Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    RAW264.7 IC50
    10.99 3
    Compound: Indometacin
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Greiss reagent based assay
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Greiss reagent based assay
    		[PMID: 34352712]
    Platelet IC50
    0.14 3
    Compound: indomethacin
    Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation
    Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation
    		[PMID: 17197180]
    RAW264.7 IC50
    11.6 3
    Compound: Indomethacin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    		[PMID: 27276091]
    Platelet IC50
    >100 3
    Compound: indomethacin
    Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation
    Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation
    		[PMID: 17197180]
    RAW264.7 IC50
    12.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 23755850]
    Platelet IC50
    1.62 3
    Compound: Indomethacin
    Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins before arachidonic acid challenge by turbidimetric method
    Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins before arachidonic acid challenge by turbidimetric method
    		[PMID: 23639653]
    RAW264.7 IC50
    12.5 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 26702644]
    Platelet IC50
    0.1 3
    Compound: Indomethacin
    Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    HeLa EC50
    0.14 1
    Compound: 1, IMN
    Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay
    Agonist activity at androgen receptor (unknown origin) expressed in HeLa cells co-expressing PSA-(ARE)4-Luc13 assessed as induction of DHT-induced luciferase activity after 20 mins by luciferase reporter gene assay
    		[PMID: 23432095]
    RAW264.7 IC50
    12.96 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
    		[PMID: 20879743]
    Platelet IC50
    0.21 3
    Compound: Indomethacin
    Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet-rich blood by turbidimetric method
    Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet-rich blood by turbidimetric method
    		[PMID: 8988600]
    HeLa IC50
    50 3
    Compound: Indomethacin
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    HeLa IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    Platelet IC50
    2.8 3
    Compound: Indomethacin
    Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    RAW264.7 IC50
    12.96 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotometry
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotometry
    		[PMID: 21807513]
    RAW264.7 IC50
    13.2 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    		[PMID: 27865705]
    Platelet IC50
    3.2 3
    Compound: Indomethacin
    Inhibition of epinephrine hydrochloride-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of epinephrine hydrochloride-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    HeLa IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32987314]
    HeLa IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32987314]
    Raji IC50
    >50 3
    Compound: C
    Cytotoxicity against human Raji cells after 72 hrs by luminescence assay
    Cytotoxicity against human Raji cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    RAW264.7 IC50
    14.1 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 1 day by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 1 day by Griess assay
    		[PMID: 25821895]
    RAW IC50
    15.37 3
    Compound: indomethacin
    Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISA
    Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISA
    		[PMID: 21381754]
    RAW264.7 IC50
    148 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 23566521]
    HepG2 IC50
    > 50 3
    Compound: C
    Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
    Cytotoxicity against human HepG2 cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    RAW IC50
    48.89 3
    Compound: indomethacin
    Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysis
    Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysis
    		[PMID: 21381754]
    RAW264.7 IC50
    15.8 3
    Compound: Indomethacin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    		[PMID: 24963714]
    RAW264.7 IC50
    16.5 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reagent based assay
    		[PMID: 27575472]
    RAW IC50
    23.47 3
    Compound: indomethacin
    Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method
    Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method
    		[PMID: 21381754]
    J774 IC50
    0.002 3
    Compound: Indomethacin
    In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cells
    In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cells
    		[PMID: 15857149]
    RAW264.7 CC50
    >200 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 27575472]
    RAW264.7 IC50
    16.67 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 26615888]
    RAW264.7 CC50
    >50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 31365251]
    RAW264.7 IC50
    16.67 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 24660966]
    J774 IC50
    0.009 3
    Compound: Indomethacin
    In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cells
    In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cells
    		[PMID: 15857149]
    J774 IC50
    29.6 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 24268542]
    RAW264.7 CC50
    >50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 2 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 2 hrs by MTT assay
    		[PMID: 38394380]
    RAW264.7 IC50
    16.7 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based assay
    		[PMID: 33533247]
    RAW264.7 IC50
    10.99 3
    Compound: Indometacin
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Greiss reagent based assay
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Greiss reagent based assay
    		[PMID: 34352712]
    RAW264.7 IC50
    18.7 3
    Compound: Indomethacin
    Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
    Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
    		[PMID: 24963714]
    J774 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against mouse J774 cells assessed as cell survival after 24 hrs by MTT assay
    Cytotoxicity against mouse J774 cells assessed as cell survival after 24 hrs by MTT assay
    		[PMID: 24268542]
    RAW264.7 IC50
    20 3
    Compound: Indo
    Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production for 2 hrs by DAF-FMDA dye based fluorometric assay
    Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production for 2 hrs by DAF-FMDA dye based fluorometric assay
    		[PMID: 22633833]
    RAW264.7 IC50
    40.7 3
    Compound: INDO
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation for 20 hrs by Griess reagent based assay
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation for 20 hrs by Griess reagent based assay
    		[PMID: 35175765]
    RAW264.7 IC50
    21.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 1 hr followed by LPS stimulation measured after 24 hrs by griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 1 hr followed by LPS stimulation measured after 24 hrs by griess assay
    		[PMID: 29261312]
    RAW264.7 IC50
    26.2 6
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
    		[PMID: 33422907]
    RAW264.7 IC50
    41 3
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
    		[PMID: 30920218]
    RAW264.7 IC50
    24 3
    Compound: Indomethacin
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation measured after 48 hrs by MTT assay
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation measured after 48 hrs by MTT assay
    		[PMID: 33160760]
    RAW264.7 IC50
    42.3 3
    Compound: Indometacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 36 hrs by Griess reagent based assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 36 hrs by Griess reagent based assay
    		[PMID: 35512012]
    RAW264.7 IC50
    26.2 6
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
    		[PMID: 33422907]
    RAW264.7 IC50
    33.6 3
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
    		[PMID: 30024153]
    RAW264.7 IC50
    32.2 3
    Compound: Indomethacin
    Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 32247751]
    RAW264.7 IC50
    6.3 3
    Compound: indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production after 24 hrs
    		[PMID: 25621853]
    RAW264.7 IC50
    32.3 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production for 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production for 24 hrs by Griess assay
    		[PMID: 33422907]
    RAW264.7 IC50
    33.6 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 28960979]
    RAW264.7 IC50
    24 3
    Compound: Indomethacin
    Antiinflammatory activity in LPS induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 2 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity in LPS induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 2 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    		[PMID: 38394380]
    J774.A1 IC50
    28.42 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774A1 cells assessed as reduction of LPS-induced nitric oxide production treated 2 hrs before LPS addition measured after 20 hrs by using Griess reagent
    Antiinflammatory activity in mouse J774A1 cells assessed as reduction of LPS-induced nitric oxide production treated 2 hrs before LPS addition measured after 20 hrs by using Griess reagent
    		[PMID: 23688954]
    RAW264.7 IC50
    33.6 3
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
    		[PMID: 30024153]
    RAW264.7 IC50
    24 3
    Compound: Indomethacin
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation measured after 48 hrs by MTT assay
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation measured after 48 hrs by MTT assay
    		[PMID: 33160760]
    J774.A1 IC50
    28.56 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production treated 2 hrs before LPS challenge measured after 20 hrs
    Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production treated 2 hrs before LPS challenge measured after 20 hrs
    		[PMID: 25140384]
    RAW264.7 IC50
    34.28 3
    Compound: Indomethacin
    Inhibition of LPS induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
    Inhibition of LPS induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
    		[PMID: 35660249]
    RAW264.7 IC50
    3.9 3
    Compound: indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production
    		[PMID: 24960143]
    RAW264.7 IC50
    38 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs coincubated with LPS by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs coincubated with LPS by Griess reagent based assay
    		[PMID: 31365251]
    RAW264.7 IC50
    38 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs coincubated with LPS by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs coincubated with LPS by Griess reagent based assay
    		[PMID: 31365251]
    K562 IC50
    190 3
    Compound: Indomethacin
    Anticancer activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    RAW264.7 IC50
    1.25 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
    		[PMID: 25442320]
    RAW264.7 IC50
    4.5 3
    Compound: Indo
    Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells using L-Arginine substrate incubated for 2 hrs by fluorescence spectrometry
    Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells using L-Arginine substrate incubated for 2 hrs by fluorescence spectrometry
    		[PMID: 25881822]
    L02 IC50
    > 100 3
    Compound: Indomethacin
    Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
    Antiproliferative activity against human LO2 cells after 72 hrs by CCK-8 assay
    		[PMID: 28301815]
    RAW264.7 IC50
    40.3 3
    Compound: Indo
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 2 hrs before LPS challenge measured 18 hrs post LPS challenge by Griess method
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 2 hrs before LPS challenge measured 18 hrs post LPS challenge by Griess method
    		[PMID: 25555141]
    RAW264.7 IC50
    14.1 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 1 day by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 1 day by Griess assay
    		[PMID: 25821895]
    RAW264.7 IC50
    40.7 3
    Compound: INDO
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation for 20 hrs by Griess reagent based assay
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation for 20 hrs by Griess reagent based assay
    		[PMID: 35175765]
    RAW264.7 IC50
    12.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 23755850]
    RAW264.7 IC50
    42.6 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 25945867]
    RAW264.7 IC50
    41 3
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
    		[PMID: 30920218]
    RAW264.7 IC50
    42.2 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation measured after 20 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation measured after 20 hrs by Griess assay
    		[PMID: 26710212]
    RAW264.7 IC50
    148 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 23566521]
    RAW264.7 IC50
    16.67 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 24660966]
    RAW264.7 IC50
    42.3 3
    Compound: Indometacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 36 hrs by Griess reagent based assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 36 hrs by Griess reagent based assay
    		[PMID: 35512012]
    RAW264.7 IC50
    42.6 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as LPS-stimulated inhibition of nitric oxide production incubated simultaneously with LPS for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as LPS-stimulated inhibition of nitric oxide production incubated simultaneously with LPS for 24 hrs by Griess reagent based assay
    		[PMID: 26024020]
    RAW264.7 IC50
    46.5 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite accumulation by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite accumulation by Griess method
    		[PMID: 28561586]
    RAW264.7 IC50
    42.6 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 25945867]
    RAW264.7 IC50
    >10 3
    Compound: Ind
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
    		[PMID: 32823004]
    RAW264.7 IC50
    45.51 3
    Compound: Indo
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method
    		[PMID: 19931461]
    RAW264.7 IC50
    21.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 1 hr followed by LPS stimulation measured after 24 hrs by griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 1 hr followed by LPS stimulation measured after 24 hrs by griess assay
    		[PMID: 29261312]
    RAW264.7 IC50
    45.57 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent-based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent-based assay
    		[PMID: 30925056]
    RAW264.7 IC50
    8.8 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs followed by LPS challenge and measured after 12 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs followed by LPS challenge and measured after 12 hrs by Griess assay
    		[PMID: 31573805]
    RAW264.7 IC50
    26.3 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production
    		[PMID: 33422907]
    RAW264.7 IC50
    46.5 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite accumulation by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite accumulation by Griess method
    		[PMID: 28561586]
    RAW264.7 IC50
    52.8 1
    Compound: Indomethacin
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
    		[PMID: 19467877]
    RAW264.7 IC50
    1.25 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 24806310]
    RAW264.7 IC50
    6.3 3
    Compound: indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production after 24 hrs
    		[PMID: 25621853]
    LNCaP EC50
    238.4 3
    Compound: Indomethacin
    Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability
    Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability
    		[PMID: 33569941]
    RAW264.7 IC50
    16.67 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 26615888]
    LNCaP IC50
    238.4 3
    Compound: INDO
    Antiproliferative activity against human LNCAP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human LNCAP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    RAW264.7 IC50
    62.9 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    		[PMID: 31403786]
    RAW264.7 IC50
    45.51 3
    Compound: Indo
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method
    		[PMID: 19931461]
    RAW264.7 IC50
    8.8 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 18 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 18 hrs by Griess assay
    		[PMID: 32520548]
    LNCaP IC50
    > 300 3
    Compound: Indomethacin
    Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 28057407]
    RAW264.7 IC50
    16.5 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reagent based assay
    		[PMID: 27575472]
    RAW264.7 IC50
    12.96 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
    		[PMID: 20879743]
    RAW264.7 IC50
    8.8 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs followed by LPS challenge and measured after 12 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs followed by LPS challenge and measured after 12 hrs by Griess assay
    		[PMID: 31573805]
    MCF7 IC50
    > 100 3
    Compound: 4; Ind
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
    		[PMID: 36257283]
    RAW264.7 IC50
    9.2 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in presence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in presence of LPS by MTT assay
    		[PMID: 25881822]
    RAW264.7 IC50
    32.3 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production for 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production for 24 hrs by Griess assay
    		[PMID: 33422907]
    Sf9 IC50
    0.75 3
    Compound: 1, Indomethacin
    Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-layer chromatography analysis
    Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-layer chromatography analysis
    		[PMID: 21524587]
    RAW264.7 IC50
    16.7 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based assay
    		[PMID: 33533247]
    MCF7 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    MCF7 IC50
    > 1000 3
    Compound: Indomethacin
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    SK-LU-1 IC50
    > 1000 3
    Compound: Indomethacin
    Anticancer activity against human SKLU1 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human SKLU1 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    RAW264.7 IC50
    8.8 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 18 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 18 hrs by Griess assay
    		[PMID: 32520548]
    RAW264.7 IC50
    45.57 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent-based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent-based assay
    		[PMID: 30925056]
    SW480 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    MCF7 IC50
    > 50 3
    Compound: 1
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35468536]
    RAW264.7 IC50
    42.2 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation measured after 20 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation measured after 20 hrs by Griess assay
    		[PMID: 26710212]
    SW480 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32987314]
    MCF7 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    MCF7 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32987314]
    SW480 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32987314]
    RAW264.7 IC50
    34.49 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by griess reagent based assay
    		[PMID: 36450214]
    RAW264.7 IC50
    0.62 3
    Compound: Ind
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    		[PMID: 36888988]
    MCF7 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32987314]
    TERT-RPE1 IC50
    > 40 3
    Compound: 1
    Cytotoxicity against human RPE-1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human RPE-1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35468536]
    THP-1 IC50
    > 10 3
    Compound: indomethacin
    Effect of pyrrolidine derivatives on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    Effect of pyrrolidine derivatives on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    		[PMID: 10737736]
    RAW264.7 IC50
    42.6 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as LPS-stimulated inhibition of nitric oxide production incubated simultaneously with LPS for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as LPS-stimulated inhibition of nitric oxide production incubated simultaneously with LPS for 24 hrs by Griess reagent based assay
    		[PMID: 26024020]
    MDA-MB-231 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    RAW264.7 IC50
    13.2 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    		[PMID: 27865705]
    THP-1 IC50
    > 10 3
    Compound: indomethacin
    Inhibition of arachidonic acid production from THP-1 cells stimulated with A-23187 using cellular assay
    Inhibition of arachidonic acid production from THP-1 cells stimulated with A-23187 using cellular assay
    		[PMID: 10737736]
    THP-1 IC50
    0.0036 3
    Compound: indomethacin
    Effect on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    Effect on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    		[PMID: 10737736]
    RAW264.7 IC50
    >50 3
    Compound: Indomethacin
    Cytotoxicity against LPS-induced mouse RAW264.7 cells assessed as reduction in cell viability
    Cytotoxicity against LPS-induced mouse RAW264.7 cells assessed as reduction in cell viability
    		[PMID: 30925056]
    U-251 IC50
    20.45 3
    Compound: Indomethacin
    Anticancer activity against human U251 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human U251 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    RAW264.7 IC50
    >100 3
    Compound: indomethacin
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 21381754]
    U-937 IC50
    0.02 3
    Compound: Indomethacin
    Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells incubated in low concentration of arachidonic acid
    Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells incubated in low concentration of arachidonic acid
    		[PMID: 9873621]
    RAW264.7 IC50
    >80 3
    Compound: Indo
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 25555141]
    VCaP IC50
    136.9 3
    Compound: INDO
    Antiproliferative activity against human VCaP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human VCaP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    RAW264.7 IC50
    >80 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the absence of LPS
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the absence of LPS
    		[PMID: 22633833]
    MDCK-II IC50
    235 3
    Compound: Indomethacin
    Inhibition of human MRP2 expressed in dog MDCK2 cells
    Inhibition of human MRP2 expressed in dog MDCK2 cells
    		[PMID: 18707884]
    MIA PaCa-2 IC50
    > 100 2
    Compound: Indomethacin
    Cytotoxicity against human MIAPaCa2 cells
    Cytotoxicity against human MIAPaCa2 cells
    		[PMID: 23061607]
    Vero C1008 CC50
    > 100 3
    Compound: 1; INM
    Cytotoxicity against African green monkey Vero E6 cells infected with SARS-CoV-2 assessed as reduction of cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against African green monkey Vero E6 cells infected with SARS-CoV-2 assessed as reduction of cell viability measured after 48 hrs by MTT assay
    		[PMID: 34534839]
    RAW264.7 IC50
    10.7 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in absence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in absence of LPS by MTT assay
    		[PMID: 25881822]
    Macrophage IC50
    22 3
    Compound: indomethacin
    Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced PGE2 release by Ellman's method
    Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced PGE2 release by Ellman's method
    		[PMID: 8988605]
    RAW264.7 IC50
    9.2 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in presence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in presence of LPS by MTT assay
    		[PMID: 25881822]
    Vero C1008 CC50
    > 500 3
    Compound: 1; INM
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay
    		[PMID: 34534839]
    RAW264.7 IC50
    >40 3
    Compound: Ind
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
    		[PMID: 32823004]
    RAW264.7 IC50
    >50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells by MTT assay
    Cytotoxicity against mouse RAW264.7 cells by MTT assay
    		[PMID: 30920218]
    Mast cell IC50
    250 3
    Compound: Indomethacin
    Inhibition of compound 48/80-induced histamine release in Wister rat Peritoneal mast cells
    Inhibition of compound 48/80-induced histamine release in Wister rat Peritoneal mast cells
    		[PMID: 20586436]
    RAW264.7 IC50
    4.5 3
    Compound: Indo
    Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells using L-Arginine substrate incubated for 2 hrs by fluorescence spectrometry
    Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells using L-Arginine substrate incubated for 2 hrs by fluorescence spectrometry
    		[PMID: 25881822]
    Mast cell IC50
    250 76
    Compound: Indomethecin
    Inhibition of compound 48/80-induced histamine release in Wistar rat peritoneal mast cells
    Inhibition of compound 48/80-induced histamine release in Wistar rat peritoneal mast cells
    		[PMID: 15270561]
    RAW264.7 IC50
    20 3
    Compound: Indo
    Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production for 2 hrs by DAF-FMDA dye based fluorometric assay
    Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production for 2 hrs by DAF-FMDA dye based fluorometric assay
    		[PMID: 22633833]
    Mononuclear cell line IC50
    0.3 3
    Compound: Indomethacin
    Inhibition of human PGE-2 production.
    Inhibition of human PGE-2 production.
    		[PMID: 1995900]
    RAW264.7 IC50
    34.28 3
    Compound: Indomethacin
    Inhibition of LPS induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
    Inhibition of LPS induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
    		[PMID: 35660249]
    RAW264.7 IC50
    18.7 3
    Compound: Indomethacin
    Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
    Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
    		[PMID: 24963714]
    RAW264.7 IC50
    12.5 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 26702644]
    Neutrophil IC50
    246.35 3
    Compound: Indometacin
    Antiinflammatory activity in human neutrophils assessed as inhibition of respiratory burst
    Antiinflammatory activity in human neutrophils assessed as inhibition of respiratory burst
    		[PMID: 20576329]
    RAW264.7 IC50
    33.6 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 28960979]
    RAW264.7 IC50
    12.96 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotometry
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotometry
    		[PMID: 21807513]
    Neutrophil IC50
    271.212 3
    Compound: Indomethacin
    Antiinflammatory activity in human neutrophils assessed as inhibition of opsonized zymosan A-mediated superoxide anions production by WST-1 based respiratory burst assay
    Antiinflammatory activity in human neutrophils assessed as inhibition of opsonized zymosan A-mediated superoxide anions production by WST-1 based respiratory burst assay
    		[PMID: 22437110]
    Neutrophil IC50
    31.98 6
    Compound: Indomethacin
    Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
    Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
    		[PMID: 21848266]
    RAW264.7 IC50
    62.9 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    		[PMID: 31403786]
    Neutrophil IC50
    32 3
    Compound: Indomethacin
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release
    		[PMID: 21316977]
    RAW264.7 IC50
    40.3 3
    Compound: Indo
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 2 hrs before LPS challenge measured 18 hrs post LPS challenge by Griess method
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 2 hrs before LPS challenge measured 18 hrs post LPS challenge by Griess method
    		[PMID: 25555141]
    RAW264.7 IC50
    15.8 3
    Compound: Indomethacin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    		[PMID: 24963714]
    Neutrophil IC50
    38.3 3
    Compound: Indomethacin
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
    Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
    		[PMID: 21316977]
    RAW264.7 IC50
    11.6 3
    Compound: Indomethacin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    		[PMID: 27276091]
    Neutrophil IC50
    38.32 6
    Compound: Indomethacin
    Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
    Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
    		[PMID: 21848266]
    Neutrophil IC50
    757.99 6
    Compound: indomethacin
    Antiinflammatory activity in human neutrophils assessed inhibition of superoxide anions production
    Antiinflammatory activity in human neutrophils assessed inhibition of superoxide anions production
    		[PMID: 19006373]
    RAW264.7 IC50
    32.2 3
    Compound: Indomethacin
    Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 32247751]
    Neutrophil IC50
    > 40 3
    Compound: indomethacin
    Antiinflammatory activity in neutrophil assessed as inhibition of fMLP induced elastase release
    Antiinflammatory activity in neutrophil assessed as inhibition of fMLP induced elastase release
    		[PMID: 17197180]
    Neutrophil IC50
    > 40 3
    Compound: indomethacin
    Antiinflammatory activity in neutrophils assessed as inhibition of oxygen radical generation
    Antiinflammatory activity in neutrophils assessed as inhibition of oxygen radical generation
    		[PMID: 17197180]
    PC-3 IC50
    > 100 3
    Compound: Indomethacin
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
    		[PMID: 20583750]
    PC-3 IC50
    > 1000 3
    Compound: Indomethacin
    Anticancer activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    Sf9 IC50
    7.81 3
    Compound: Indomethacin
    In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 expressed in sf-9 cells infected with baculovirus
    In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 expressed in sf-9 cells infected with baculovirus
    		[PMID: 15026050]
    Peritoneal macrophage IC50
    147.5 3
    Compound: Indomethacin
    Anti-inflammatory activity against LPS-stimulated mouse peritoneal macrophage assessed as reduction in nitric oxide production
    Anti-inflammatory activity against LPS-stimulated mouse peritoneal macrophage assessed as reduction in nitric oxide production
    		[PMID: 37683361]
    Sf9 IC50
    0.75 3
    Compound: 1, Indomethacin
    Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-layer chromatography analysis
    Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-layer chromatography analysis
    		[PMID: 21524587]
    Sf9 IC50
    12.4 3
    Compound: 1
    Inhibitory concentration against human recombinant Prostaglandin G/H synthase 1 cloned and expressed in baculovirus (Sf9)
    Inhibitory concentration against human recombinant Prostaglandin G/H synthase 1 cloned and expressed in baculovirus (Sf9)
    		[PMID: 11392547]
    SK-LU-1 IC50
    >1 2
    Compound: Indomethacin
    Anticancer activity against human SKLU1 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human SKLU1 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    SW480 IC50
    >50 3
    Compound: Indometacin
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    TERT-RPE1 IC50
    >40 3
    Compound: 1
    Cytotoxicity against human RPE-1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human RPE-1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35468536]
    THP-1 IC50
    >10 3
    Compound: Indomethacin
    Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    Platelet IC50
    0.1 3
    Compound: Indomethacin
    Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    THP-1 IC50
    >10 3
    Compound: indomethacin
    Effect of pyrrolidine derivatives on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    Effect of pyrrolidine derivatives on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    		[PMID: 10737736]
    Platelet IC50
    0.14 3
    Compound: indomethacin
    Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation
    Anticoagulant activity assessed as inhibition of arachidonic acid induced rabbit platelet aggregation
    		[PMID: 17197180]
    THP-1 IC50
    0.0036 3
    Compound: indomethacin
    Effect on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    Effect on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    		[PMID: 10737736]
    Platelet IC50
    0.21 3
    Compound: Indomethacin
    Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet-rich blood by turbidimetric method
    Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet-rich blood by turbidimetric method
    		[PMID: 8988600]
    THP-1 IC50
    >100 3
    Compound: Indomethacin
    In vitro effect on production of lipopolysaccharide (LPS) -induced IL1-beta in human THP-1 cells
    In vitro effect on production of lipopolysaccharide (LPS) -induced IL1-beta in human THP-1 cells
    		[PMID: 10821716]
    Platelet IC50
    1.62 3
    Compound: Indomethacin
    Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins before arachidonic acid challenge by turbidimetric method
    Antiplatelet activity in human platelet rich plasma assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins before arachidonic acid challenge by turbidimetric method
    		[PMID: 23639653]
    U-251 IC50
    20.45 3
    Compound: Indomethacin
    Anticancer activity against human U251 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human U251 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    Platelet IC50
    2.8 3
    Compound: Indomethacin
    Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of collagen-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    Platelet IC50
    3.2 3
    Compound: Indomethacin
    Inhibition of epinephrine hydrochloride-induced platelet aggregation in human platelet-rich plasma after 5 mins
    Inhibition of epinephrine hydrochloride-induced platelet aggregation in human platelet-rich plasma after 5 mins
    		[PMID: 114655]
    U-937 IC50
    0.002 3
    Compound: 1 Indomethacin
    In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells
    In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells
    		[PMID: 12877584]
    Platelet IC50
    > 100 3
    Compound: indomethacin
    Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation
    Anticoagulant activity assessed as inhibition of thrombin induced rabbit platelet aggregation
    		[PMID: 17197180]
    U-937 IC50
    0.02 3
    Compound: Indomethacin
    Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.
    Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.
    		[PMID: 10576685]
    U-937 IC50
    0.003 3
    Compound: 1
    Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma
    Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma
    		[PMID: 11462976]
    U-937 IC50
    0.02 3
    Compound: Indomethacin
    Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells incubated in low concentration of arachidonic acid
    Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells incubated in low concentration of arachidonic acid
    		[PMID: 9873621]
    VCaP IC50
    136.9 3
    Compound: INDO
    Antiproliferative activity against human VCaP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human VCaP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    Vero C1008 CC50
    >500 3
    Compound: 1; INM
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay
    		[PMID: 34534839]
    RAW IC50
    15.37 3
    Compound: indomethacin
    Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISA
    Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISA
    		[PMID: 21381754]
    Vero C1008 CC50
    >100 3
    Compound: 1; INM
    Cytotoxicity against African green monkey Vero E6 cells infected with SARS-CoV-2 assessed as reduction of cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against African green monkey Vero E6 cells infected with SARS-CoV-2 assessed as reduction of cell viability measured after 48 hrs by MTT assay
    		[PMID: 34534839]
    RAW IC50
    23.47 3
    Compound: indomethacin
    Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method
    Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method
    		[PMID: 21381754]
    RAW IC50
    48.89 3
    Compound: indomethacin
    Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysis
    Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysis
    		[PMID: 21381754]
    RAW264.7 CC50
    > 200 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
    		[PMID: 27575472]
    RAW264.7 CC50
    > 50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 31365251]
    RAW264.7 CC50
    > 50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 2 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 2 hrs by MTT assay
    		[PMID: 38394380]
    RAW264.7 IC50
    0.62 3
    Compound: Ind
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production preincubated for 3 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    		[PMID: 36888988]
    RAW264.7 IC50
    1.25 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
    		[PMID: 24806310]
    RAW264.7 IC50
    1.25 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
    		[PMID: 25442320]
    RAW264.7 IC50
    10.7 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in absence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in absence of LPS by MTT assay
    		[PMID: 25881822]
    RAW264.7 IC50
    10.99 3
    Compound: Indometacin
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Greiss reagent based assay
    Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Greiss reagent based assay
    		[PMID: 34352712]
    RAW264.7 IC50
    11.6 3
    Compound: Indomethacin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    		[PMID: 27276091]
    RAW264.7 IC50
    12.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 23755850]
    RAW264.7 IC50
    12.5 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 26702644]
    RAW264.7 IC50
    12.96 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotometry
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction based spectrophotometry
    		[PMID: 21807513]
    RAW264.7 IC50
    12.96 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
    		[PMID: 20879743]
    RAW264.7 IC50
    13.2 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
    		[PMID: 27865705]
    RAW264.7 IC50
    14.1 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 1 day by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 1 day by Griess assay
    		[PMID: 25821895]
    RAW264.7 IC50
    148 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 23566521]
    RAW264.7 IC50
    15.8 3
    Compound: Indomethacin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
    		[PMID: 24963714]
    RAW264.7 IC50
    16.5 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reagent based assay
    		[PMID: 27575472]
    RAW264.7 IC50
    16.67 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 24660966]
    RAW264.7 IC50
    16.67 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
    		[PMID: 26615888]
    RAW264.7 IC50
    16.7 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based assay
    		[PMID: 33533247]
    RAW264.7 IC50
    17.64 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production by ELISA analysis
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production by ELISA analysis
    		[PMID: 37683361]
    RAW264.7 IC50
    18.7 3
    Compound: Indomethacin
    Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
    Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
    		[PMID: 24963714]
    RAW264.7 IC50
    20 3
    Compound: Indo
    Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production for 2 hrs by DAF-FMDA dye based fluorometric assay
    Inhibition of iNOS in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production for 2 hrs by DAF-FMDA dye based fluorometric assay
    		[PMID: 22633833]
    RAW264.7 IC50
    21.1 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 1 hr followed by LPS stimulation measured after 24 hrs by griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 1 hr followed by LPS stimulation measured after 24 hrs by griess assay
    		[PMID: 29261312]
    RAW264.7 IC50
    24 3
    Compound: Indomethacin
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation measured after 48 hrs by MTT assay
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation measured after 48 hrs by MTT assay
    		[PMID: 33160760]
    RAW264.7 IC50
    24 3
    Compound: Indomethacin
    Antiinflammatory activity in LPS induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 2 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity in LPS induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 2 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
    		[PMID: 38394380]
    RAW264.7 IC50
    26.2 6
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
    		[PMID: 33422907]
    RAW264.7 IC50
    26.3 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production
    		[PMID: 33422907]
    RAW264.7 IC50
    3.9 3
    Compound: indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production
    		[PMID: 24960143]
    RAW264.7 IC50
    32.2 3
    Compound: Indomethacin
    Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
    		[PMID: 32247751]
    RAW264.7 IC50
    32.3 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production for 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production for 24 hrs by Griess assay
    		[PMID: 33422907]
    RAW264.7 IC50
    33.6 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 28960979]
    RAW264.7 IC50
    33.6 3
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
    		[PMID: 30024153]
    RAW264.7 IC50
    34.28 3
    Compound: Indomethacin
    Inhibition of LPS induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
    Inhibition of LPS induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent based assay
    		[PMID: 35660249]
    RAW264.7 IC50
    34.49 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated with compound for 1 hrs followed by LPS-stimulation and measured after 24 hrs by griess reagent based assay
    		[PMID: 36450214]
    RAW264.7 IC50
    37.5 3
    Compound: Indomethacin
    Inhibition of NO production in LPS-induced mouse RAW264.7 cells incubated for 24 hrs by absorbance based assay
    Inhibition of NO production in LPS-induced mouse RAW264.7 cells incubated for 24 hrs by absorbance based assay
    		[PMID: 39110498]
    RAW264.7 IC50
    38 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs coincubated with LPS by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs coincubated with LPS by Griess reagent based assay
    		[PMID: 31365251]
    RAW264.7 IC50
    4.5 3
    Compound: Indo
    Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells using L-Arginine substrate incubated for 2 hrs by fluorescence spectrometry
    Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells using L-Arginine substrate incubated for 2 hrs by fluorescence spectrometry
    		[PMID: 25881822]
    RAW264.7 IC50
    40.3 3
    Compound: Indo
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 2 hrs before LPS challenge measured 18 hrs post LPS challenge by Griess method
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells pre-incubated for 2 hrs before LPS challenge measured 18 hrs post LPS challenge by Griess method
    		[PMID: 25555141]
    RAW264.7 IC50
    40.7 3
    Compound: INDO
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation for 20 hrs by Griess reagent based assay
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 2 hrs followed by LPS stimulation for 20 hrs by Griess reagent based assay
    		[PMID: 35175765]
    RAW264.7 IC50
    41 3
    Compound: Indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
    		[PMID: 30920218]
    RAW264.7 IC50
    42.2 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation measured after 20 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation measured after 20 hrs by Griess assay
    		[PMID: 26710212]
    RAW264.7 IC50
    42.3 3
    Compound: Indometacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 36 hrs by Griess reagent based assay
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 36 hrs by Griess reagent based assay
    		[PMID: 35512012]
    RAW264.7 IC50
    42.6 3
    Compound: Indomethacin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as LPS-stimulated inhibition of nitric oxide production incubated simultaneously with LPS for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as LPS-stimulated inhibition of nitric oxide production incubated simultaneously with LPS for 24 hrs by Griess reagent based assay
    		[PMID: 26024020]
    RAW264.7 IC50
    42.6 3
    Compound: indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 25945867]
    RAW264.7 IC50
    45.51 3
    Compound: Indo
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method
    		[PMID: 19931461]
    RAW264.7 IC50
    45.57 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent-based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition and measured after 24 hrs by Griess reagent-based assay
    		[PMID: 30925056]
    RAW264.7 IC50
    46.5 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite accumulation by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite accumulation by Griess method
    		[PMID: 28561586]
    RAW264.7 IC50
    52.8 1
    Compound: Indomethacin
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method
    		[PMID: 19467877]
    RAW264.7 IC50
    56.8 3
    Compound: Indo
    Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs incubation by Griess analysis
    Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs incubation by Griess analysis
    		[PMID: 37224762]
    RAW264.7 IC50
    6.3 3
    Compound: indomethacin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production after 24 hrs
    Antiinflammatory activity against mouse RAW264.7 cells assessed as reduction of LPS-induced NO production after 24 hrs
    		[PMID: 25621853]
    RAW264.7 IC50
    62.9 3
    Compound: Indomethacin
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
    		[PMID: 31403786]
    RAW264.7 IC50
    7.31 3
    Compound: IND
    Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 23 hrs by Griess method
    Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 23 hrs by Griess method
    		[PMID: 39140047]
    RAW264.7 IC50
    8.5 3
    Compound: Indomethacin
    Anti-inflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production incubated for 24 hrs by Griess reagent based assay
    		[PMID: 37683361]
    RAW264.7 IC50
    8.8 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs followed by LPS challenge and measured after 12 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 2 hrs followed by LPS challenge and measured after 12 hrs by Griess assay
    		[PMID: 31573805]
    RAW264.7 IC50
    8.8 3
    Compound: Indomethacin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 18 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 18 hrs by Griess assay
    		[PMID: 32520548]
    RAW264.7 IC50
    9.2 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in presence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs in presence of LPS by MTT assay
    		[PMID: 25881822]
    RAW264.7 IC50
    > 10 3
    Compound: Ind
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
    		[PMID: 32823004]
    RAW264.7 IC50
    > 100 3
    Compound: indomethacin
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 21381754]
    RAW264.7 IC50
    > 100 3
    Compound: indomethacin
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 21381754]
    RAW264.7 IC50
    > 40 3
    Compound: Ind
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
    		[PMID: 32823004]
    RAW264.7 IC50
    > 40 3
    Compound: Ind
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in presence of LPS by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in presence of LPS by MTT assay
    		[PMID: 32823004]
    RAW264.7 IC50
    > 50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells by MTT assay
    Cytotoxicity against mouse RAW264.7 cells by MTT assay
    		[PMID: 30920218]
    RAW264.7 IC50
    > 50 3
    Compound: Indomethacin
    Cytotoxicity against LPS-induced mouse RAW264.7 cells assessed as reduction in cell viability
    Cytotoxicity against LPS-induced mouse RAW264.7 cells assessed as reduction in cell viability
    		[PMID: 30925056]
    RAW264.7 IC50
    > 50 3
    Compound: Indomethacin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability
    		[PMID: 30925056]
    RAW264.7 IC50
    > 80 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the absence of LPS
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the absence of LPS
    		[PMID: 22633833]
    RAW264.7 IC50
    > 80 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the presence of LPS
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay in the presence of LPS
    		[PMID: 22633833]
    RAW264.7 IC50
    > 80 3
    Compound: Indo
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 25555141]
    RAW264.7 IC50
    > 80 3
    Compound: Indo
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay
    		[PMID: 25555141]
    RBL-1 IC50
    0.0037 41
    Compound: Indomethacin
    In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
    In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
    		[PMID: 8254620]
    RBL-1 IC50
    0.5 3
    Compound: 6
    Inhibition of Prostaglandin G/H synthase in intact RBL-1 cell line
    Inhibition of Prostaglandin G/H synthase in intact RBL-1 cell line
    		[PMID: 2115586]
    RBL-1 IC50
    0.5 3
    Compound: Ia
    Tested for inhibition of cyclooxygenase (ARBC) in calcium-stimulated rat basophilic leukemia cells(RBL-1)
    Tested for inhibition of cyclooxygenase (ARBC) in calcium-stimulated rat basophilic leukemia cells(RBL-1)
    		10.1016/S0960-894X(00)80450-3
    RBL-1 IC50
    0.5 3
    Compound: Indomethacin
    Compound was evaluated for its inhibitory activity against CO(cyclooxygenase) in intact RBL-1 cell line assay
    Compound was evaluated for its inhibitory activity against CO(cyclooxygenase) in intact RBL-1 cell line assay
    		10.1016/S0960-894X(00)80396-0
    RBL-1 IC50
    > 100 3
    Compound: 6
    Inhibition of 5-lipoxygenase in intact RBL-1 cell line
    Inhibition of 5-lipoxygenase in intact RBL-1 cell line
    		[PMID: 2115586]
    RBL-1 IC50
    > 100 3
    Compound: Ia
    Tested for inhibition of 5-Lipoxygenase (ARBL) in calcium-stimulated rat basophilic leukemia cells(RBL-1)
    Tested for inhibition of 5-Lipoxygenase (ARBL) in calcium-stimulated rat basophilic leukemia cells(RBL-1)
    		10.1016/S0960-894X(00)80450-3
    RBL-1 IC50
    > 100 3
    Compound: Indomethacin
    Compound was evaluated for its inhibitory activity against 5-LO (5-lipoxygenase) in intact RBL-1 cell line assay
    Compound was evaluated for its inhibitory activity against 5-LO (5-lipoxygenase) in intact RBL-1 cell line assay
    		10.1016/S0960-894X(00)80396-0
    RBL-1 IC50
    > 25 3
    Compound: Indomethacin
    Inhibitory activity against 5-lipoxygenase of RBL-1 cell line
    Inhibitory activity against 5-lipoxygenase of RBL-1 cell line
    		[PMID: 1507204]
    RBL-1 IC50
    >> 20 3
    Compound: indomethacin
    Inhibition of 5-lipoxygenase in rat RBL-1 cells
    Inhibition of 5-lipoxygenase in rat RBL-1 cells
    		[PMID: 2319562]
    Raji IC50
    > 50 3
    Compound: C
    Cytotoxicity against human Raji cells after 72 hrs by luminescence assay
    Cytotoxicity against human Raji cells after 72 hrs by luminescence assay
    		[PMID: 20129783]
    SK-LU-1 IC50
    > 1000 3
    Compound: Indomethacin
    Anticancer activity against human SKLU1 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human SKLU1 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    SW480 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 32987314]
    SW480 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
    		[PMID: 32987314]
    SW480 IC50
    > 50 3
    Compound: Indometacin
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 32987314]
    Sf21 IC50
    35.2 3
    Compound: Indometacin
    Inhibition of human recombinant COX2 expressed in baculovirus infected SF21 cell
    Inhibition of human recombinant COX2 expressed in baculovirus infected SF21 cell
    		[PMID: 20974503]
    Sf9 IC50
    0.75 3
    Compound: 1, Indomethacin
    Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-layer chromatography analysis
    Inhibition of human COX2 expressed in SF-9 insect cells assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-layer chromatography analysis
    		[PMID: 21524587]
    Sf9 IC50
    12.4 3
    Compound: 1
    Inhibitory concentration against human recombinant Prostaglandin G/H synthase 1 cloned and expressed in baculovirus (Sf9)
    Inhibitory concentration against human recombinant Prostaglandin G/H synthase 1 cloned and expressed in baculovirus (Sf9)
    		[PMID: 11392547]
    Sf9 IC50
    30 1
    Compound: 1
    Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)
    Inhibitory concentration against human recombinant Prostaglandin G/H synthase 2 cloned and expressed in baculovirus (Sf9)
    		[PMID: 11392547]
    Sf9 IC50
    7.81 3
    Compound: Indomethacin
    In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 expressed in sf-9 cells infected with baculovirus
    In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 expressed in sf-9 cells infected with baculovirus
    		[PMID: 15026050]
    TERT-RPE1 IC50
    > 40 3
    Compound: 1
    Cytotoxicity against human RPE-1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against human RPE-1 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 35468536]
    THP-1 IC50
    0.0036 3
    Compound: indomethacin
    Effect on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    Effect on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    		[PMID: 10737736]
    THP-1 IC50
    19.37 3
    Compound: Indomethacin
    Anti-inflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated NO production by ELISA analysis
    Anti-inflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated NO production by ELISA analysis
    		[PMID: 37683361]
    THP-1 IC50
    3.6 1
    Compound: Indomethacin
    Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    THP-1 IC50
    > 10 3
    Compound: indomethacin
    Effect of pyrrolidine derivatives on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    Effect of pyrrolidine derivatives on production of eicosanoids from THP-1 cells stimulated with A-23187 using cellular assay on PGE-2, LTC-4
    		[PMID: 10737736]
    THP-1 IC50
    > 10 3
    Compound: indomethacin
    Inhibition of arachidonic acid production from THP-1 cells stimulated with A-23187 using cellular assay
    Inhibition of arachidonic acid production from THP-1 cells stimulated with A-23187 using cellular assay
    		[PMID: 10737736]
    THP-1 IC50
    > 100 3
    Compound: Indomethacin
    In vitro effect on production of lipopolysaccharide (LPS) -induced IL1-beta in human THP-1 cells
    In vitro effect on production of lipopolysaccharide (LPS) -induced IL1-beta in human THP-1 cells
    		[PMID: 10821716]
    THP-1 IC50
    > 10000 1
    Compound: Indomethacin
    Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    THP-1 IC50
    > 10000 1
    Compound: Indomethacin
    Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    U-251 IC50
    20.45 3
    Compound: Indomethacin
    Anticancer activity against human U251 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    Anticancer activity against human U251 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
    		[PMID: 32527536]
    U-937 IC50
    0.002 3
    Compound: 1 Indomethacin
    In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells
    In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells
    		[PMID: 12877584]
    U-937 IC50
    0.003 3
    Compound: 1
    Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma
    Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma
    		[PMID: 11462976]
    U-937 IC50
    0.02 3
    Compound: Indomethacin
    Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.
    Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.
    		[PMID: 10576685]
    U-937 IC50
    0.02 3
    Compound: Indomethacin
    Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells incubated in low concentration of arachidonic acid
    Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells incubated in low concentration of arachidonic acid
    		[PMID: 9873621]
    VCaP IC50
    136.9 3
    Compound: INDO
    Antiproliferative activity against human VCaP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    Antiproliferative activity against human VCaP cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 30996776]
    Vero C1008 CC50
    > 100 3
    Compound: 1; INM
    Cytotoxicity against African green monkey Vero E6 cells infected with SARS-CoV-2 assessed as reduction of cell viability measured after 48 hrs by MTT assay
    Cytotoxicity against African green monkey Vero E6 cells infected with SARS-CoV-2 assessed as reduction of cell viability measured after 48 hrs by MTT assay
    		[PMID: 34534839]
    Vero C1008 CC50
    > 500 3
    Compound: 1; INM
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability measured after 72 hrs by MTT assay
    		[PMID: 34534839]
    In Vitro

    Indomethacin (Indometacin) (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro[2].
    Indomethacin (Indometacin) (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC50=2μM)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Indomethacin Related Antibodies

    Cell Viability Assay[2]

    Cell Line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells)
    Concentration: 0, 20, 50, 100 and 150 μM
    Incubation Time: 24 hours
    Result: Inhibited cell viability at 20 mM, with 50% inhibition at 60 mM.

    Cell Viability Assay[2]

    Cell Line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells)
    Concentration: 0, 30 and 80 μM
    Incubation Time: 24 hours
    Result: Decreased in the percentage of cells at the G2/M phase and increased in the percentage of cells at G1 phase.
    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Indomethacin can be used to induce gastric ulcer models. After oral administration, the drug is absorbed rapidly and completely, although there are interindividual and intraindividual variations. Typically, the plasma peak concentration (2-3 μg/mL) is reached within 1-2 hours. However, coadministration with food reduces and delays the peak concentration without affecting the total absorption. At therapeutic concentrations, 90% of Indomethacin is bound to albumin in the plasma[4].

    Induction of gastric ulceration[5][6]
    Background
    Indomethacin can cause gastric ulceration by various mechanisms, including injury through inhibition of prostaglandin (PG) synthesis, reduction in local blood flow, regional irritation, and inhibition of tissue regeneration.
    Specific Modeling Methods
    Rat: albino Sprague-Dawley • male • adult (period: 2 weeks)
    Administration: 100 mg/kg • p.o. • single dose
    Note
    (1) All animals fasted 24 h before drug administration.
    (2) Indomethacin was dissolved in saline with 5% NaOH.
    Modeling Indicators
    Gastric tissue macroscopic alterations: Showed prominent mucosal folds and severe erosion, pronounced ulceration and bleeding foci in the gastric mucosa.
    Histopathological changes: Showed severe erosion of the mucosa, reaching down to the lamina muscularis; observed hemorrhagic infiltration, edema in the submucosa, and severe hyperemia of the vessels.
    Molecular changes: Showed intense Tnf-α expression.
    Biochemical changes: Increased MDA, TOS levels, reduced TAS levels, CAT and GPx activities and GSH levels.
    Correlated Product(s): Indomethacin sodium hydrate (HY-14397A)
    Opposite Product(s): Carnosic acid (HY-N0644)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Sprague-Dawley rats[1]
    Dosage: 0.01-10 mg/kg
    Administration: Oral administration; for 3 hours
    Result: Inhibited the carrageenan-induced rat paw oedema (ED50=2.0 mg/kg) and hyperalgesia (ED50=1.5 mg/kg) in a dose-dependent manner.
    Animal Model: Male C57BL/6J mice[2]
    Dosage: 10 mg/mL
    Administration: Oral administration; daily, for 29 days
    Result: Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.
    Peso molecular

    357.79

    Fòrmula

    C19H16ClNO4
    No. CAS
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    COC1=CC=C(N(C(C2=CC=C(Cl)C=C2)=O)C(C)=C3CC(O)=O)C3=C1
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    4°C, protect from light

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

    Solvente y solubilidad
    In Vitro: 

    DMSO : 100 mg/mL (279.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 12.5 mg/mL (34.94 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7949 mL 13.9747 mL 27.9494 mL
    5 mM 0.5590 mL 2.7949 mL 5.5899 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (5.81 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (5.81 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Pureza y Documentación

    Purity: 99.90%

    SDS (480 KB)

    COA (253 KB) HNMR (279 KB) RP-HPLC (245 KB) MS (69 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 2.7949 mL 13.9747 mL 27.9494 mL 69.8734 mL
    5 mM 0.5590 mL 2.7949 mL 5.5899 mL 13.9747 mL
    10 mM 0.2795 mL 1.3975 mL 2.7949 mL 6.9873 mL
    15 mM 0.1863 mL 0.9316 mL 1.8633 mL 4.6582 mL
    20 mM 0.1397 mL 0.6987 mL 1.3975 mL 3.4937 mL
    25 mM 0.1118 mL 0.5590 mL 1.1180 mL 2.7949 mL
    30 mM 0.0932 mL 0.4658 mL 0.9316 mL 2.3291 mL
    DMSO 40 mM 0.0699 mL 0.3494 mL 0.6987 mL 1.7468 mL
    50 mM 0.0559 mL 0.2795 mL 0.5590 mL 1.3975 mL
    60 mM 0.0466 mL 0.2329 mL 0.4658 mL 1.1646 mL
    80 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.8734 mL
    100 mM 0.0279 mL 0.1397 mL 0.2795 mL 0.6987 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Indomethacin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Indomethacin53-86-1IndometacinCOXAntibioticInfluenza VirusBacterialCyclooxygenaseanti-infectiveanticancerinflammationCOX-1COX-2Inhibitorinhibitorinhibit

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