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Indomethacin sodium hydrate

(Synonyms: Indometacin sodium hydrate)
83 Cited Publications
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Based on 83 publication(s) in Google Scholar

Indomethacin (Indometacin) sodium hydrateis a orally active and BBB-permeable COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrateis has anticancer activity and anti-infective activity. Indomethacin sodium hydrateis can be used for cancer, inflammation and viral infection research.

For research use only. We do not sell to patients.

  • Purity: 99.85%
  • CAS No.: 74252-25-8
  • Formula: C19H21ClNNaO7
  • Molecular Weight:433.82
  • Storage:

    4°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

  • Indomethacin sodium hydrate Chemical Structure
    Indomethacin sodium hydrate Chemical Structure
  • Experimental Validation Results for Indomethacin sodium hydrate
  • Experimental Validation Results for Indomethacin sodium hydrate
  • Experimental Validation Results for Indomethacin sodium hydrate
  • Experimental Validation Results for Indomethacin sodium hydrate
  • Experimental Validation Results for Indomethacin sodium hydrate
  • Experimental Validation Results for Indomethacin sodium hydrate
CAS No.: 74252-25-8
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Indomethacin sodium hydrate Chemical Structure
    Indomethacin sodium hydrate Chemical Structure
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    Indomethacin sodium hydrate purchased from MedChemExpress. Usage Cited in: Hepatology. 2023 Feb 1;77(2):456-465. [Abstract]

    Customer Validation
     WT BmEos was treated with IL-33 (20 ng/ml) in the presence or absence of indomethacin (50 μM) for 24 h. Protein levels of IL-4 and IL-13 in the supernatants were measured by ELISA.

  • 1/16

    Indomethacin sodium hydrate purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548. [Abstract]

    Customer Validation
     ITGAV, ITGB3, p-FAK, FAK, p-PI3K, PI3K, p-AKT, AKT, p-GSK3β, and GSK3β protein levels were assessed in KYSE30 cells by Western blotting after treatment with DMSO or 200 µM Indomethacin (0–96 h).

  • 1/16

    Indomethacin sodium hydrate purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548. [Abstract]

    Customer Validation
     HEK-293T cells were co-transfected with FLAG-ITGAV and HA-ubiquitin plasmids, pre-treated with MG132 for 12 h, and then incubated with indomethacin (200 µM) for 2 days.

  • 1/16

    Indomethacin sodium hydrate purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548. [Abstract]

    Customer Validation
     KYSE30 and KYSE510 cells were treated with DMSO or Indomethacin for 24 h, followed by the detection of ITGAV protein levels using immunofluorescence.

  • 1/16

    Indomethacin sodium hydrate purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548. [Abstract]

    Customer Validation
     ESCC cells were treated with DMSO or different concentrations of Indomethacin for various times (24, 48, or 96 h). Cell growth inhibition was detected by MTT assay.

  • 1/16

    Indomethacin sodium hydrate purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2021 Oct;11(10):e548. [Abstract]

    Customer Validation
     PDX tumour size was plotted over 41 days (LEG74, n = 8/group), 26 days (LEG92, n = 12/group), or 13 days (LEG84, n = 10/group) to assess the effect of Indomethacin. Vehicle or indomethacin (1 or 4 mg/kg) was administered intra-gastrically. Tumour volumes were measured twice per week.

  • Indomethacin sodium hydrate