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    Autophagy
  2. COX
    Autophagy
  3. Indomethacin farnesil

Indomethacin farnesil (Synonyms: Indometacin farnesil)

Cat. No.: HY-111274
Handling Instructions

Indomethacin farnesil is an orally active prodrug of Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes.

For research use only. We do not sell to patients.

Indomethacin farnesil Chemical Structure

Indomethacin farnesil Chemical Structure

CAS No. : 85801-02-1

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Other Forms of Indomethacin farnesil:

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Description

Indomethacin farnesil is an orally active prodrug of Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[1][2].

In Vitro

Indometacin farnesil (IMF) is a newly synthesized prodrug of indomethacin designed to reduce the occurrence of side-effects by esterification of the carboxyl group of indomethacin with farnesol. This modification is intended to decrease the extraction and subsequent rapid metabolism of the drug by the liver, so that lymphatic absorption would become a major route, and it was also anticipates that hydrolytic enzymes present in plasma and tissues, including inflamed tissue, would release indomethacin effectively from IMF[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Indomethacin farnesil (IMF) can effectively release indomethacin when administered locally[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1].
Dosage: 50 nmol a rat paw.
Administration: Once.
Result: Reduced the level of PGE2 in a dose dependent manner.
Molecular Weight

562.14

Formula

C₃₄H₄₀ClNO₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Indomethacin farnesil
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