Indomethacin-d₄ Methyl Ester

Name: Indomethacin-d 4 Methyl Ester
Brand: MedChemExpress
SKU: HY-14397S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-14397S1 Purity: 98.38%: FAQs
Data Sheet SDS COA Handling Instructions

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Indomethacin-d₄ Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

For research use only. We do not sell to patients.

Indomethacin-d<sub>4</sub> Methyl Ester Chemical Structure

Indomethacin-d₄ Methyl Ester Chemical Structure

CAS No. : 1217064-61-3

Size	Price	Stock	Quantity
1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 820	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Indomethacin-d₄ Methyl Ester:

Indomethacin In-stock

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•Related Proteins:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

375.84

Formula

C₂₀H₁₄D₄ClNO₄

CAS No.

1217064-61-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)N2C3=CC=C(OC)C=C3C(CC(OC)=O)=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (266.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6607 mL	13.3035 mL	26.6071 mL
5 mM	0.5321 mL	2.6607 mL	5.3214 mL
10 mM	0.2661 mL	1.3304 mL	2.6607 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.38%

Select Batch:

Data Sheet (279 KB) SDS (251 KB)

COA (258 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [Content Brief]

[3]. Jorge Vallecillo-Hernández, et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8(1):3593. [Content Brief]

[4]. Lopes RS, et al. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. J Biosci. 2016 Sep;41(3):381-94. [Content Brief]

[5]. Afroz S, et al. Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer. J Agric Food Chem. 2016 Aug 26. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6607 mL	13.3035 mL	26.6071 mL	66.5177 mL
	5 mM	0.5321 mL	2.6607 mL	5.3214 mL	13.3035 mL
	10 mM	0.2661 mL	1.3304 mL	2.6607 mL	6.6518 mL
	15 mM	0.1774 mL	0.8869 mL	1.7738 mL	4.4345 mL
	20 mM	0.1330 mL	0.6652 mL	1.3304 mL	3.3259 mL
	25 mM	0.1064 mL	0.5321 mL	1.0643 mL	2.6607 mL
	30 mM	0.0887 mL	0.4435 mL	0.8869 mL	2.2173 mL
	40 mM	0.0665 mL	0.3326 mL	0.6652 mL	1.6629 mL
	50 mM	0.0532 mL	0.2661 mL	0.5321 mL	1.3304 mL
	60 mM	0.0443 mL	0.2217 mL	0.4435 mL	1.1086 mL
	80 mM	0.0333 mL	0.1663 mL	0.3326 mL	0.8315 mL
	100 mM	0.0266 mL	0.1330 mL	0.2661 mL	0.6652 mL