Indomethacin-d4 Methyl Ester
Based on 1 Customer Validation
Indomethacin-d4 Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes.
For research use only. We do not sell to patients.
- Purity: 98.38%
- CAS No.: 1217064-61-3
- Formula: C20H14D4ClNO4
- Molecular Weight:375.84
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217064-61-3
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Unlabeled Cas 1601-18-9
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Appearance Solid
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Molecular Weight 375.84
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Formula C20H14D4ClNO4
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Color White to off-white
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SMILES
O=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)N2C3=CC=C(OC)C=C3C(CC(OC)=O)=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (266.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [Content Brief]
[3]. Jorge Vallecillo-Hernández, et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8(1):3593. [Content Brief]
[4]. Lopes RS, et al. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. J Biosci. 2016 Sep;41(3):381-94. [Content Brief]
[5]. Afroz S, et al. Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer. J Agric Food Chem. 2016 Aug 26. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6607 mL | 13.3035 mL | 26.6071 mL | 66.5177 mL |
| 5 mM | 0.5321 mL | 2.6607 mL | 5.3214 mL | 13.3035 mL | |
| 10 mM | 0.2661 mL | 1.3304 mL | 2.6607 mL | 6.6518 mL | |
| 15 mM | 0.1774 mL | 0.8869 mL | 1.7738 mL | 4.4345 mL | |
| 20 mM | 0.1330 mL | 0.6652 mL | 1.3304 mL | 3.3259 mL | |
| 25 mM | 0.1064 mL | 0.5321 mL | 1.0643 mL | 2.6607 mL | |
| 30 mM | 0.0887 mL | 0.4435 mL | 0.8869 mL | 2.2173 mL | |
| 40 mM | 0.0665 mL | 0.3326 mL | 0.6652 mL | 1.6629 mL | |
| 50 mM | 0.0532 mL | 0.2661 mL | 0.5321 mL | 1.3304 mL | |
| 60 mM | 0.0443 mL | 0.2217 mL | 0.4435 mL | 1.1086 mL | |
| 80 mM | 0.0333 mL | 0.1663 mL | 0.3326 mL | 0.8315 mL | |
| 100 mM | 0.0266 mL | 0.1330 mL | 0.2661 mL | 0.6652 mL |
Indomethacin-d4 Methyl Ester Related Classifications
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