Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin-Induced Stomach Ulcer

  • J Agric Food Chem. 2016 Sep 21;64(37):6950-7. doi: 10.1021/acs.jafc.6b02884.
Sheuli Afroz  1 ,  Teru Ikoma  1 ,  Ayano Yagi  1 ,  Kentaro Kogure  1 ,  Akira Tokumura  2 ,  Tamotsu Tanaka  1
Affiliations
  • 1. Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima 770-8505, Japan.
  • 2. Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Yasuda Women's University , Hiroshima 731-0351, Japan.
PMID: 27561232 DOI: 10.1021/acs.jafc.6b02884
Abstract

One of complications associated with long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is peptic ulcer. Recently, we found that orally administered phosphatidic acid (PA) ameliorated aspirin-induced stomach lesions in mice. In this study, we identified PA-rich food sources and examined the effects of the food Materials on indomethacin-induced stomach ulcer. Among examined, buckwheat (Fagopyrum esculentum) bran contained the highest level of PA (188 mg/100 g). PA was the richest phospholipid (25%) in the lipid fraction of the buckwheat bran. Administration of the lipid extracts of buckwheat bran significantly ameliorated indomethacin-induced stomach lesions in mice. In contrast, wheat (Triticum durum) bran lipids (PA, 4%) and soybean (Glycine max) lipids (PA, 3%) were not associated with ameliorative effects. These results indicated that PA-rich lipids can be used as an effective supplement for prevention of NSAID-induced stomach ulcer.

Keywords
cereal brans; lysophosphatidic acid; phosphatidic acid; phospholipase A2; stomach ulcer.
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